Hypoxia

Litvitsky, P.F.

doi:10.15690/vsp.v15i1.1499

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Активация системы транспорта кислорода и субстратов метаболизма к клеткам сопровождается интенсивным расходом энергетического субстрата. Это может стать лимитирующим фактором степени и продолжительности гиперактивности транспортных систем организма [3,4].…”

Section: патогенез экзогенных типов гипоксииunclassified

See 1 more Smart Citation

Asphyxia with a reduced oxygen content in the environment (clinical lecture)

Yekhalov¹,

Сединкин²,

Кравець³

2021

ЕМ

View full text Add to dashboard Cite

Asphyxia due to a decrease in oxygen concentration in the inhaled air is not common. Nevertheless, the mass media fairly regularly inform the population about its episodes in wine cellars, silos, and children in closed spaces. Quite a serious problem is exogenous hypoxia in miners as a result of accidents with the release of firedamp, carbon dioxide poisoning of submarine crews in case of failure of ventilation systems. The modern extreme sports enthusiast who are actively engaged in mountain tourism and mountaineering, speleology (including diggers), amateur piloting of sports aircraft and balloons, diving, etc. are subject to such lesions. In the available special literature sources on the topic “Asphyxiation due to a decrease in the concentration of oxygen in the environment”, there are almost no reports related to lifetime pathogenetic characteristics, diagnosis, and the basics of providing medical care to such victims. There are isolated recommendations on the provision of medical care for mountain sickness, while other options for exogenous asphyxia are considered only from the standpoint of forensic medical examination, in most cases — posthumously. Based on isolated domestic and foreign research works, personal theoretical and clinical experience, we have developed an algorithm for diagnosis and medical care at the stages of the route of a victim with exogenous hypoxia.

show abstract

Section: патогенез экзогенных типов гипоксииunclassified

“…Изменение содержания в организме гормонов, регулирующих обмен минералокортикоидов, кальцитонина и др. [3,5].…”

Section: нарушение обмена веществ при гипоксииunclassified

Asphyxia with a reduced oxygen content in the environment (clinical lecture)

Yekhalov¹,

Сединкин²,

Кравець³

2021

ЕМ

View full text Add to dashboard Cite

show abstract

Chronic respiratory failure correction in cicatricial laryngeal and tracheal stenosis using helium-oxygen mixture

Кирасирова¹,

Frolkina²,

Rybalchenko³

et al. 2022

Vestn. otorinolaringol.

View full text Add to dashboard Cite

Pathophysiological aspects of oxygen, hypoxia and free radical oxidation in critical conditions

Orlov

Sviridov²,

Kakulya

2021

Clinical nutrition and metabolism

View full text Add to dashboard Cite

Oxygen is the main regulator of metabolic processes in the body not only in the context of normal physiology, but also in the development of various critical conditions. In recent years, the problem of pathogenesis of a number organs' and systems' diseases has been enriched by knowledge of the mechanism of damage to cellular structures. Oxygen turned out to be the main factor of damage the very oxygen, due to the lack of which cell death occurs. It turned out that the so-called reactive oxygen species having an unpaired electron have a biological effect, which, depending on the concentration, can be regulatory or, conversely, toxic. Accordingly, interest has also been aroused in compounds that normally prevent the toxic effect of reactive oxygen species antioxidants. Today it is generally recognized that oxidative stress plays an important and possibly a key role in the pathogenesis of critical conditions. Thus, on the one side, excessive production of free radicals is considered as one of the manifestations of the body's protective reaction to the effects of various environmental factors and living conditions (infections, injuries, toxins, ionizing radiation, physical stress, hypothermia, hypoxia, various types of stress), on the other ― increased production of free radicals quickly leads to irreversible damage: destruction of the erythrocytes' membranes with subsequent hemolysis, transformation of hemoglobin into methemoglobin, DNA damage, desensitization of plasma membrane receptors, inactivation of various hormones and enzymes, including antiradical and antiperoxide protection enzymes. The problem of using oxygen in critical conditions is currently widely discussed in the periodical literature with an emphasis on the oxygen concentrations used in patients, both in operating rooms and in intensive care units. Oxygen used in the intensive care of acute respiratory failure and hypoxia should have a certain concentration range. The toxic effects of oxygen can occur with its prolonged use in high concentrations, which causes not only its direct toxic effect on the lungs, but also in the potentiation of the activation of free radical oxidation and excessive production of reactive oxygen species. The review presents current data on the physiological role of oxygen, its participation in metabolic processes against the background of inflammation, hypoxia and under conditions of activation of free radical oxidation processes. The recent approach to oxygen therapy and the research data presented in the review urge to relate to oxygen as a drug in order to avoid manifestations of its toxic effects.

show abstract

Hypoxia

Cited by 8 publications

References 0 publications

Asphyxia with a reduced oxygen content in the environment (clinical lecture)

Asphyxia with a reduced oxygen content in the environment (clinical lecture)

Chronic respiratory failure correction in cicatricial laryngeal and tracheal stenosis using helium-oxygen mixture

Pathophysiological aspects of oxygen, hypoxia and free radical oxidation in critical conditions

Contact Info

Product

Resources

About