Hypovitaminosis D in African Americans Residing in Memphis, Tennessee With and Without Heart Failure

Alsafwah, Shadwan; LaGuardia, S. P.; Nelson, M. D.; Battin, David L.; Newman, Kevin P.; Carbone, Laura D; Weber, Karl T.

doi:10.1097/maj.0b013e318167b0bd

Cited by 54 publications

(53 citation statements)

References 37 publications

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“…Mean serum 25-OH-D concentration was significantly lower in patients with heart failure compared with controls. Similar results or a higher prevalence of suboptimal vitamin D status have been observed in North American, 61 African-American, [62][63][64] Egyptian, 65 and Iranian 66 heart failure populations. Ameri and colleagues 60 measured vitamin D status in 90 patients admitted to the hospital with heart failure and 31 controls without heart disease.…”

Section: Intervention Studiessupporting

confidence: 78%

The Role of Micronutrients in Heart Failure

McKeag

McKinley²,

Woodside³

et al. 2012

Journal of the Academy of Nutrition and Dietetics

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Section: Intervention Studiessupporting

confidence: 78%

The Role of Micronutrients in Heart Failure

McKeag

McKinley²,

Woodside³

et al. 2012

Journal of the Academy of Nutrition and Dietetics

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“…Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85]. Interestingly, not all heart-failure patients with vitamin D deficiency show elevations in PTH levels but those with secondary hyperparathyroidism have more severe forms of heart failure [83][84][85]. In a cohort of over 3000 patients referred for coronary angiography 25(OH)D as well as 1,25(OH)D were inversely correlated with left ventricular dysfunction, New York Heart Association functional class and N-terminal pro-B type natriuretic peptide (NT-pro-BNP) [86].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 96%

“…Zittermann et al found significantly reduced 25(OH)D and 1,25(OH)2D levels in 54 heart-failure patients when compared with 34 age-, sex-, and BMI-matched controls [82]. In a study among 102 African Americans, vitamin D deficiency was observed in 84-96% of heart-failure patients, whereas only one-third of the healthy controls was vitamin D deficient [83]. Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 97%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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“…The secondary aldosteronism of CHF in man leads to increased fecal and urinary Ca 2þ excretion and consequent ionized hypocalcemia and, in turn, SHPT with elevated plasma PTH levels [53,[73][74][75][76]. As noted earlier, dyshomeostasis of divalent cations frequently occurs in patients hospitalized with decompensated biventricular failure due to a dilated (idiopathic) cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Stressor States and the Cation Crossroads

Weber¹,

Bhattacharya²,

Newman³

et al. 2010

Journal of the American College of Nutrition

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Neurohormonal activation involving the hypothalamic-pituitary-adrenal axis and adrenergic nervous and renin-angiotensin-aldosterone systems is integral to stressor state-mediated homeostatic responses. The levels of effector hormones, depending upon the degree of stress, orchestrate the concordant appearance of hypokalemia, ionized hypocalcemia and hypomagnesemia, hypozincemia, and hyposelenemia. Seemingly contradictory to homeostatic responses wherein the constancy of extracellular fluid would be preserved, upregulation of cognate-binding proteins promotes coordinated translocation of cations to injured tissues, where they participate in wound healing. Associated catecholamine-mediated intracellular cation shifts regulate the equilibrium between pro-oxidants and antioxidant defenses, a critical determinant of cell survival. These acute and chronic stressor-induced iterations in extracellular and intracellular cations are collectively referred to as the cation crossroads. Intracellular cation shifts, particularly excessive accumulation of Ca2+, converge on mitochondria to induce oxidative stress and raise the opening potential of their inner membrane permeability transition pores (mPTPs). The ensuing loss of cationic homeostasis and adenosine triphosphate (ATP) production, together with osmotic swelling, leads to organellar degeneration and cellular necrosis. The overall impact of iterations in extracellular and intracellular cations and their influence on cardiac redox state, cardiomyocyte survival, and myocardial structure and function are addressed herein.

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Hypovitaminosis D in African Americans Residing in Memphis, Tennessee With and Without Heart Failure

Cited by 54 publications

References 37 publications

The Role of Micronutrients in Heart Failure

The Role of Micronutrients in Heart Failure

Vitamin D deficiency and myocardial diseases

Stressor States and the Cation Crossroads

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