Stressor States and the Cation Crossroads

Weber, Karl T.; Bhattacharya, Syamal K.; Newman, Kevin P.; Soberman, Judith E.; Ramanathan, Kodangudi B.; McGee, Jesse E.; Malik, Kafait U.; Hickerson, William L.

doi:10.1080/07315724.2010.10719895

Cited by 6 publications

(5 citation statements)

References 129 publications

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“…[7] Genetic differences in magnesium utilization may account for differences in vulnerability to magnesium deficiency and differences in body responses to stress. [89] In our study, we found 76.47% patients of hypomagnesemia were on magnesium lowering drugs while as 46% of normomagnesemic patients were on magnesium lowering drugs. The difference was statistically significant ( P = 0.030).…”

Section: Discussionmentioning

confidence: 51%

Significance of serum magnesium levels in critically ill-patients

Zafar

Wani

Karim

et al. 2014

Int J App Basic Med Res

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Background:Magnesium is one of the major electrolytes, deficiency of which is frequently overlooked in critical illness, leading to an adverse clinical outcome if not monitored regularly.Settings and Design:Single center prospective observational study of 2 years duration.Materials and Methods:The subjects studied were monitored for serum magnesium levels 2 times: Day 1 and day 4 of intensive care unit (ICU) admission. Patients were divided into normomagnesemic and hypomagnesemic groups and compared for various parameters.Results:Out of 70 critically ill-patients, 50 patients (71.43%) were normomagnesemic, 17 patients (24.29%) were hypomagnesemic and three patients were hypermagnesemic. The stay of the patients in ICU (P > 0.05), Acute Physiology and Chronic Health Evaluation-II (APACHE-II) scoring (P = 0.34) and co-morbidity (P = 0.360) showed an insignificant variation between the two groups. Associated electrolyte abnormalities in hypomagnesemic patients were hypokalemia (58.82%), hyponatremia (47.05%), hypocalcemia (70.58%) and hypophosphatemia (29.41%). About 76.47% of hypomagnesemic population was on magnesium lowering drugs while as 46% of normomagnesemic population was on magnesium lowering drugs (P = 0.030). Mortality of hypomagnesemic group was 74.47% while that of normomagnesemic group was 36% (P = 0.004).Conclusion:Hypomagnesemia is a significant electrolyte abnormality in critically ill-patients. Critically ill hypomagnesemic patients have higher mortality than the normomagnesemic patients.

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Section: Discussionmentioning

confidence: 51%

Significance of serum magnesium levels in critically ill-patients

Zafar

Wani

Karim

et al. 2014

Int J App Basic Med Res

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“…Under conditions of acute stress, Se may be mobilized from SeMet-containing proteins in peripheral tissues and transported by selenoprotein P to the liver to facilitate increased biosynthesis of glutathione peroxidases. Glutathione peroxidases are then used to remove the increased amounts of reactive oxygen species produced during stress or to maintain redox status in cells (Weber et al, 2010). In support, in Chinook salmon that were transported by barge for 30 h, tissue Se concentrations of their frozen eviscerated carcasses decreased by 20% after the barge trip (Halver et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Effect of transport on blood selenium and glutathione status in feeder lambs1

Hall

Bobe

Nixon

et al. 2014

Journal of Animal Science

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Stress from transport may be linked to increased generation of reactive oxygen species, the removal of which requires reduced glutathione and selenium. The aim of this experiment was to examine the effect of transport on glutathione and Se status of feeder lambs. Recently weaned lambs (n = 40) were blocked by gender and BW on d 0 of the experiment and randomly assigned to 2 treatment groups: group 1, no transport and full access to feed and water (control), and group 2, 8-h road transport followed by another 16 h of feed deprivation (transport). After 24 h, both treatment groups were treated the same. All lambs were weighed, and blood samples were collected at 0, 8, 24, and 72 h and analyzed for whole-blood (WB) and serum Se concentrations, serum NEFA concentrations, and erythrocyte concentrations of glutathione. Transport of feeder lambs for 8 h followed by another 16 h of feed deprivation transiently (significant at 24 h but no longer different at 72 h) decreased BW and erythrocyte glutathione concentrations and increased serum NEFA and blood Se concentrations compared with control lambs. Our results suggest that 8 h of transport followed by another 16 h of feed deprivation results in fatty acid and Se mobilization from tissue stores with a coincident decrease in erythrocyte glutathione concentrations.

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“…Because the intake of Mg is often inadequate and several other factors are also known to impair Mg supply (for example, diuretics use, diabetes mellitus, chronic alcohol consumption, stress factors) [16-18], more attention should in future be paid to possible consequences of insufficient or deficient Mg supply in the general population. Further studies on the interactions between Mg supply and vitamin D status should include a more detailed assessment of individual Mg status (for example, by measuring biochemical parameters of Mg status or by adjusting statistical analysis for stress factors, diuretics use, alcohol consumption and concomitant diagnoses such as diabetes); a more detailed investigation of different components of the vitamin D-parathyroid hormone axis in general populations; clarification of the dose?response relationship; and the realization of randomized controlled trials to verify whether oral Mg is indeed able to improve vitamin D status and survival.…”

Section: Resultsmentioning

confidence: 99%

Magnesium deficit - overlooked cause of low vitamin D status?

Zittermann

2013

BMC Med

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Like vitamin D deficit, magnesium deficit is considered to be a risk factor for cardiovascular disease. Several steps in the vitamin D metabolism, such as vitamin D binding to its transport protein and the conversion of vitamin D into the hormonal form 1,25-dihydroxyvitamin D by hepatic and renal hydroxylation, depend on magnesium as a cofactor. A new analysis of two National Health and Nutrition Examination Surveys data sets, published in BMC Medicine, investigated potential interactions between magnesium intake, circulating 25-hydroxyvitamin D, which is the generally accepted indicator of vitamin D status, and mortality. Data indicate a reduced risk of insufficient/deficient vitamin D status at high magnesium intake and an inverse association between circulating 25-hydroxyvitamin D and mortality, particularly cardiovascular mortality, among those with magnesium intake above the median. The study provides important findings concerning potential metabolic interactions between magnesium and vitamin D and its clinical relevance. However, results should be considered preliminary since biochemical data on individual magnesium status were lacking, confounding cannot be excluded and questions on the dose?response relationship still remain to be answered.Please see related research article: http://www.biomedcentral.com/1741-7015/11/187.

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Stressor States and the Cation Crossroads

Cited by 6 publications

References 129 publications

Significance of serum magnesium levels in critically ill-patients

Significance of serum magnesium levels in critically ill-patients

Effect of transport on blood selenium and glutathione status in feeder lambs1

Magnesium deficit - overlooked cause of low vitamin D status?

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