Hypovitaminosis D and hypocalcemic seizures in infancy

Mehrotra, Prateek K.; Marwaha, Raman K.; Aneja, Satinder; Seth, Anju; Singla, Bhupesh; Ashraf, Ganie M.; Sharma, Bhu Dev; Sastry, A. V. R.; Tandon, Nikhil

doi:10.1007/s13312-010-0131-1

Cited by 53 publications

(36 citation statements)

References 29 publications

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“…This was supported by Mehrotra et al who evaluated association of maternal hypo-vitaminosis with neonatal hypocalcemia. 35 They included 60 infants with hypocalcemic seizures and their mothers (study group) and 60 healthy breastfed infants with their lactating mothers (control group). High prevalence of hypovitaminosis D (<10 ng/mL) was observed in study mothers (85%).…”

Section: Discussionmentioning

confidence: 99%

Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level

Sahu¹,

Tripathy

Bhuyan

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Vitamin D deficiency has been associated with various poor maternal and fetal outcome and is proposed to be important in the pathogenesis of preeclampsia. The aim of the study was to evaluate the serum vitamin-D levels in normal pregnant females and pre-eclampsia or eclampsia individuals in the third trimester admitted for termination or in labour and to assess the neonatal outcome and neonatal serum calcium levels of babies born to mother in both the groups.Methods: This study was a prospective comparative study carried out on the pregnant women in the third trimester admitted for termination or in labour. 100 pregnant females with either pre-eclampsia or eclampsia were compared with equal number of normotensive pregnant females for serum vitamin D. They were followed up until delivery and subsequently neonatal serum calcium level was estimated.Results: Most pregnant females had vitamin D deficiency pointing towards universal prevalence. Only 10% had suboptimal to optimal vitamin D level while 90% had vitamin deficiency. The hypertensive group had lower mean serum vitamin D level (9.06±5.20 ng/ml) as compared to normotensive group (13.67±7.24 ng/ml). Neonatal outcome was poorer in the hypertensive group. Neonates born to hypertensive mothers had lower mean calcium level (8.30±1.46mg/dl) when compared to those born to normotensive mothers (8.82±0.918mg/dl).Conclusion: The study findings revealed that there lies a consistent association of maternal serum vitamin D deficiency with the hypertensive disorders of pregnancy and neonatal morbidity.

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Section: Discussionmentioning

confidence: 99%

Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level

Sahu¹,

Tripathy

Bhuyan

2017

Int J Reprod Contracept Obstet Gynecol

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“…17 Evidence suggests that vitamin D improves insulin sensitivity by enhancing insulin responsiveness to glucose transport. 18 The association between low vitamin D levels and gestational diabetes mellitus (GDM) is also 6 In our study, there was a moderate positive correlation between maternal and cord blood vitamin D levels (r Value: 0.596, P value: <0.001) .…”

Section: Resultsmentioning

confidence: 52%

A study to evaluate serum 25-hydroxy vitamin D3 and calcium levels in maternal and cord blood and their effect on pregnancy outcome

Thangappah

Sampson

Azad

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: To determine the prevalence of vitamin D deficiency among pregnant mothers and their neonates and to study the effect of vitamin D deficiency on maternal and perinatal outcome.Methods: This prospective cohort study conducted in a teaching hospital included 223 pregnant mothers and their offspring born in 2017. Detailed history was taken to ascertain the causes of vitamin D deficiency. vitamin D3 and calcium levels were estimated in maternal and cord blood samples. To study the association between the vitamin D status and the various maternal and neonatal parameters.Results: 91.9 % of women were house wives involved in indoor activities. Pre-eclampsia and GDM were seen in 4.5% of cases each. 5.41% were obese and 84% were of medium complexion, and 8% were dark. 93.7% were non- vegetarians, and fish, egg and milk consumption was adequate in 61.3% , 64% and 71% respectively. Only 5.40% of women had adequate exposure to sunlight. The mean birth weight was 3.08± 0.36 Kg. and 14 babies were admitted to NICU for neonatal asphyxia.77.40% had deficient levels of vitamin D <20 ng/ml. Only four pregnant mothers (1.8%) had sufficient levels vitamin D. There was no statistically significant association between vitamin D deficiency and various maternal and neonatal parameters.Conclusions: This study has shown that the prevalence of vitamin D deficiency among south Indian pregnant mothers and their newborn is very high and the ways to improve the vitamin D status among pregnant mothers should be looked at.

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“…There has also recently been a report of hypovitaminosis-D-induced hypocalcemia being related to increased seizures in infancy [115]. In general seizures remit when the patient is treated with cholecalciferol to treat the hypocalcemia.…”

Section: Vitamin D and Models Of Epilepsymentioning

confidence: 99%

Vitamin D

Eyles

McGrath

2011

Vitamin D

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Hypovitaminosis D and hypocalcemic seizures in infancy

Abstract: Vitamin D deficiency is a major cause of hypocalcemic seizures in infants. Infants born to vitamin D deficient mothers are at a significantly higher risk to develop hypocalcemic seizures.

Cited by 53 publications

References 29 publications

Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level

Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level

A study to evaluate serum 25-hydroxy vitamin D3 and calcium levels in maternal and cord blood and their effect on pregnancy outcome

Vitamin D

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