Vitamin D

Eyles, Darryl W.; McGrath, John

doi:10.1016/b978-0-12-381978-9.10032-0

Cited by 8 publications

(6 citation statements)

References 185 publications

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“…Neutrophils feature four major types of storage vessels inclosing a plethora of highly potent enzymes and mediators required for decomposition of phagocytosed material; some of the contents can be mobilized to the cell surface or released upon stimulation to interact with extracellular components. 27 Azurophilic (primary) granules contain lysozyme, defensins, neutral serine proteases such as elastase, cathepsin G and proteinase 3, and the characteristic myeloperoxidase. The second species, termed specific granules, are packed with gelatinase, collagenase, lactoferrin and, again, lysozyme.…”

Section: Universal Soldiers In Inflammationmentioning

confidence: 99%

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Sexy again: the renaissance of neutrophils in psoriasis

Schön

Broekaert

Erpenbeck

2017

Experimental Dermatology

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| GETTING TO GRIPS WITH PSORIASISThe stage set to unfold before us the fascinating pathophysiology of psoriasis is ever changing. Some of the actors have added intriguing insight to our understanding of this complex inflammatory disorder.Formerly, psoriasis had been regarded as a skin disease that is based primarily on disturbances of epidermal homeostasis.1,2 In fact, even in more recent times there are some absolutely serious "pockets of resistance" providing experimental evidence that a primary epithelial abnormality alone can initiate psoriasis-like hyperproliferative inflammatory skin changes, at least in animal models. 3,4 Alas, as this is a viewpoint article, we dare to phrase the "heretic" notion that tampering with almost any component of the cutaneous environment, be it epithelium, vasculature or immune functions, can ultimately result in so-called psoriasiform inflammation. 5 The predominant current scenario, however, which is substantiated quickly by even a cursory survey of the literature, is this: psoriasis is a systemic inflammatory disorder, has an immunogenetic basis and is centred around tightly intertwined interactions of the innate and the adaptive immune system. 6-11More than 18 000 publications pertaining to the pathogenesis of

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Section: Universal Soldiers In Inflammationmentioning

confidence: 99%

“…Having stated these general points, we would like to briefly touch on an as-yet ill-studied side aspect: neutrophils also express adenosine receptors 27,30 (Fig. 2).…”

Section: Universal Soldiers In Inflammationmentioning

confidence: 99%

Sexy again: the renaissance of neutrophils in psoriasis

Schön

Broekaert

Erpenbeck

2017

Experimental Dermatology

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“…176,177 Besides these various functions, several studies have investigated the association between vitamin D with psychiatric disorders such as autism, schizophrenia, and depression. 178 Table 1 Preclinical and clinical studies showing the effects of folic acid on depression…”

Section: Tryptophanmentioning

confidence: 99%

“…179 In addition, vitamin D appears to modulate several neurotransmitter systems, including those involved in the pathogenesis of depression. 178 Some literature data associated low levels of 25(OH)D in patients with depression [180][181][182][183] or with an increase in depressive symptoms. 184 Furthermore, supplementation with vitamin D appears to improve depressive symptoms.…”

Section: Preclinical Studies Clinical Studiesmentioning

confidence: 99%

Nutritional strategies for dealing with depression

2013

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Depression is a highly recurrent and debilitating psychiatric disorder associated with multicausal origins. Impairments in the monoaminergic transmission, increased glutamatergic excitotoxicity, neuroinflammation, oxidative stress and deficits in neurotrophic factors are the main hypothesis raised in order to explain the etiological basis of depression. Although the current antidepressant therapy usually alleviates symptoms and prevents recurrence of episodes, the delay in the onset of the therapeutic effect and the refractory or intolerant responses exhibited by a large number of patients are the main drawbacks of the current therapy. For these reasons, several studies have dealt with the investigation of alternative therapeutic approaches or adjunctive strategies which could improve clinical outcomes. One potential adjunctive treatment with conventional antidepressants involves the use of nutraceuticals (a food, a part of a food, a vitamin, a mineral, or a herb that provides health benefits). In this review, we will focus on the main nutrients, phytochemicals and food that have been shown to have beneficial effects against depression.

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“…25-Hydroxyvitamin D (25-(OH) D) is a nuclear steroid transcription regulator that plays a significant role in bone mineralization, calcium phosphate absorption and osteoporosis. 1,2) The past decade witnessed studies acknowledging the extra skeletal role of the sunshine vitamin in diabetes, cancer, autoimmune disorders, neurodegenerative disorders, anorexia nervosa, obesity, mental disorders and cardiac diseases. 1,3,4) The discovery of 25-(OH) D specific receptors in the neurons and glial cells has stimulated research towards the anticonvulsant action of this vitamin.…”

Section: Introductionmentioning

confidence: 99%

Cost-Effective HPLC-UV Method for Quantification of Vitamin D<sub>2</sub> and D<sub>3</sub> in Dried Blood Spot: A Potential Adjunct to Newborn Screening for Prophylaxis of Intractable Paediatric Seizures

Mathew

Moorkoth

Rane

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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25-Hydroxyvitamin D (25-(OH)D) deficiency is recently been described as one of the multiple factors responsible for pediatric seizures. 25-Hydroxyvitamin D3 and 25-Hydroxyvitamin D2 are the well-known markers to determine Vitamin D status. In this work we report the development of a sensitive and cost effective HPLC technique for the quantification of the vitamin D metabolites from dried blood spot samples (DBS). The metabolites were extracted using acetonitrile-methanol-0.1% formic acid (60 : 20 : 20 (v/v)) and analyzed on an Acclaim C 18 column (150 4.6 mm i.d., 3 µm) at a flow rate of 1 mL/min. The method was linear in the range of 10-80 ng/mL. Limit of detection and limit of quantification (LOQ) of the method were 5 and 10 ng/mL respectively. Extensive stability studies demonstrated the analytes to be stable in stock and matrix with a percent change within the acceptable range of 15%. Comparison of the newly developed HPLC-DBS method with the reported LC-MS-DBS and electrochemiluminescence immunoassay (ECLIA) methods followed by Bland-Altman analysis demonstrated a bias of 0.08 and 0.14, respectively proving the methods are comparable. Application of the developed method to a pediatric seizure cohort depicted 46.6% of cases as deficient and 26.6% as insufficient for 25-(OH)D. Among deficient cases 8 samples were below 10 ng/mL and exact amount was not calculated since these were below the LOQ levels. The mean standard deviation (S.D.) in the remaining 6 deficient cases was 13.22 2.80 ng/mL. The levels in healthy infants were 33.9 6.11 ng/mL. The method can be used routinely for assessing 25-(OH)D deficiency in newborn.

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Vitamin D

Cited by 8 publications

References 185 publications

Sexy again: the renaissance of neutrophils in psoriasis

Sexy again: the renaissance of neutrophils in psoriasis

Nutritional strategies for dealing with depression

Cost-Effective HPLC-UV Method for Quantification of Vitamin D<sub>2</sub> and D<sub>3</sub> in Dried Blood Spot: A Potential Adjunct to Newborn Screening for Prophylaxis of Intractable Paediatric Seizures

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