Hypothermic low flow liver perfusion as a means of porcine hepatic storage for six hours

Abstract

15 had no recurrence in 2-15 years. Niceberg and others (1956) report that 7 of 26 cases treated only by appendicectomy died of proven metastatic carcinoma within 5 years.It would appear that, provided there is no pseudomyxoma peritonei, the prognosis for mucocele is excellent, and for cystadenoma it is good, but with the latter there may be local recurrence. In adenocarcinoma the prognosis is very variable. In this series, of 6 patients with adenocarcinoma, 3 have died ( I was an incidental finding at necropsy) and the others were alive 14 years, 10 years, and 2 months after the operation. It would also appear that when the diagnosis of adenocarcinoma is made unexpectedly on microscopy in an appendix removed incidentally at another operation, the prognosis is good. SUlMlMARYAn account is given of 7 columnar-cell tumours of the appendix (6 adenocarcinomas and I cystadenoma) and 2 mucoceles. The terminology, treatment, incidence, pathogenesis, and prognosis are discussed.The only constant feature in the histological differentiation between an adenocarcinoma and a cystadenoma is that there is invasion of the wall in the former. A mucocele of the appendix is lined by flattened, cuboidal epithelium or by no epithelium. The presence of papillary projections suggests a cystadenoma rather than a mucocele.Acknowledgements.-We

Tumor necrosis factor suppression and microcirculatory disturbance amelioration in ischemia/reperfusion injury of rat liver after ischemic preconditioning†

“…Hepatic I/R injury is still a major problem in liver resections or transplantations. A series of trials involving potential methods for suppressing injury has been reported, such as an intermittent method of inflow clamping, 15 cooling, 16 nitric oxide synthetase inhibitors, 17 radical scavengers, 18 and anti‐inflammatory cytokines 19 including receptor antagonists 9 . While physiological methods such as vascular clamping or hepatic cooling have already been applied clinically, other pharmacological methods cannot be used clinically because of their side‐effects or poor efficacy.…”

Twelve-hour liver preservation in the pig using hypothermia and hyperbaric oxygen

“…The failure of other investigators (Kestens, Mikaeloff, Haxhe, Dureau, Alexandre, Rassat, Cuilleret, Hassoun, Dubernard, Descotes, and Morelle, 1966;Hobbs, Hunt, Palmer, Badrick, Morris, Mitra, Peacock, Immelman, and Riddell, 1968;Belzer and others, 1970) to prolong liver preservation significantly by continuous hypothermic perfusion stimulated the present investigation of combining simple hypothermia with hyperbaric oxygen. In 1964 Manax, Bloch, Longerbeam, and Lillehei published their first report on the technique and results of hypothermia and hyperbaric oxygen in the preservation of whole organs, and they clearly demonstrated the advantages of this combination over either of the two modalities used separately.…”

Organ Preservation into the 2020s: The Era of Dynamic Intervention

“…Successful renal preservation was achieved for up to 1 day, long enough to allow transplant tissue matching and sharing of organs over a wide geographic area. Alongside these approaches, proponents of continuous hypothermic machine perfusion (HMP) continued to develop methods for use of bloodless perfusates in oxygenated low-temperature perfusion across a range of organs [13-15]. However, the logistics and reliability of the available equipment meant that gradually, flush cooling and ice storage with synthetic OPS became the most widely used preservation method and allowed techniques for multiple organ retrievals from a single donor to be developed using the so-called “flexible techniques” [16] in which all organs designated for transplantation are cooled in situ, rapidly removed in a bloodless field, and further dissected on a back table.…”