Hypothermia-Enhanced Human Tumor Cell Radiosensitivity

Burton, Steven A.; Paljug, William R.; Werts, E. Day

doi:10.1006/cryo.1997.2027

Cited by 26 publications

(12 citation statements)

References 23 publications

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“…However, as an adjunctive agent, the timing of delivery of irradiation is not clear. Experiments in vitro have shown that the radiosensitivity of cooled cells is increased [20]. One would expect that radiotherapy and cryosurgery, synchronized in some manner, would add to the efficacy of both.…”

Section: Adjunctive Therapymentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Adjunctive Therapymentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…This has been known for some time from in-vitro studies [99] and was clinically confirmed also for pancreatic and lung cancer in small case series [100,101].…”

Section: Combination Therapymentioning

confidence: 55%

Current Technique and Application of Percutaneous Cryotherapy

Mahnken

König

Figiel

2018

Fortschr Röntgenstr

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ABSTR AC TPurpose Local ablative therapies have become an established treatment option in interventional oncology. Radiofrequency ablation (RFA) and microwave ablation (MWA) are a standard of care in the treatment of hepatocellular carcinoma (HCC). Currently, there is an increasing interest in cryotherapy, one of the oldest ablation techniques. It has some unique characteristics with regard to technology and mechanism of action.Materials and Methods A systematic literature search using the terms cryotherapy, cryosurgery and cryoablation was performed. Selected studies are presented dealing with the mechanism of action, cryobiology and clinical use of percutaneous, image-guided cryoablation. Recent developments and perspectives are presented.Results Cryotherapy is increasingly used and has been included in guidelines for selected tumor entities such as renal cell carcinoma. Cryo-immunotherapy and combination treatments are future areas of interest.Conclusion Cryoabalation may be used in many indications.Its major advantages are its unique visualization and the anesthesiologic effects of cold. While there are only a few prospectively randomized trials, the existing data on the use of cryoablation is promising. Its use appears to be justified in selected tumors, oligometastatic patients and for palliative indications.

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“…Studies have also shown that cryotherapy can increase the efficacy of radiotherapy, due to the high metabolism and vascularization of the residual tumor and also because cooled cells are more radiosensitive [35,36] . Moreover, cryotherapy can be carried out in a restricted area, reducing or avoiding damage to physical vessels and normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Cryoablation Combined with Iodine-125 Implantation in the Treatment of Cardiac Metastasis from Alveolar Soft Part Sarcoma: A Case Report

et al. 2016

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Objectives: A 36-year-old Asian man was referred to our hospital with cardiac metastasis. He had a history of alveolar soft part sarcoma and initially underwent resection in 2005. Methods: After exposing the tumor by thoracotomy, cryoablation was performed under ultrasound guidance. This treatment was combined with iodine-125 seed implantation to treat the cardiac metastasis. Results: The patient had an uneventful recovery, and his cardiac function shows no obvious abnormalities. Imaging techniques suggest that cardiac metastasis was well controlled, and the patient is still alive 12 months after treatment. Conclusions: Tumor cryoablation, combined with iodine seed implantations, may be regarded as a means of palliative treatment. What Is It about?There is no effective standard systemic treatment for patients with unresectable aveolar soft part sarcoma (ASPS). Therefore, new locoregional and systemic therapies are needed. We present one of the first cases in which a patient with ASPS and cardiac metastases received palliative treatment comprising cryoablation with iodine-125 implantation. Follow-up and 1-year overall survival data indicate that the tumor was significantly controlled, and suggest that this treatment is effective. Further studies are warranted.

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Hypothermia-Enhanced Human Tumor Cell Radiosensitivity

Cited by 26 publications

References 23 publications

Experimental cryosurgery investigations in vivo

Experimental cryosurgery investigations in vivo

Current Technique and Application of Percutaneous Cryotherapy

Cryoablation Combined with Iodine-125 Implantation in the Treatment of Cardiac Metastasis from Alveolar Soft Part Sarcoma: A Case Report

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