Experimental cryosurgery investigations in vivo

Gage, Andrew A.; Baust, John M.

doi:10.1016/j.cryobiol.2009.10.001

Cited by 252 publications

(239 citation statements)

References 198 publications

(207 reference statements)

Supporting

Mentioning

211

Contrasting

Unclassified

Order By: Relevance

“…In addition, many of the surrounding structures such as the connective tissues of the nerves and blood vessels, as well as the bone, have been found to resist freeze injury [32]. The result is that the extracellular matrix and scaffold structure of the nerves and vessels remain intact, allowing the affected axon/myelin sheath or vascular cells to regenerate and repair the injury site.…”

Section: Safety Of Cryoneurolysismentioning

confidence: 96%

Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves

Ilfeld

Preciado

Trescot

2016

Expert Review of Medical Devices

View full text Add to dashboard Cite

Introduction: Cryoneurolysis is the direct application of low temperatures to reversibly ablate peripheral nerves to provide pain relief. Recent development of a handheld cryoneurolysis device with small gauge probes and an integrated skin warmer broadens the clinical applications to include treatment of superficial nerves, further enabling treatments for pre-operative pain, post-surgical pain, chronic pain, and muscle movement disorders. Areas covered: Cryoneurolysis is the direct application of cold temperatures to a peripheral nerve, resulting in reversible ablation due to Wallerian degeneration and nerve regeneration. Use over the last 50 years attests to a very low incidence of complications and adverse effects. Cryoprobes have traditionally been applied through a surgical incision; but, recent technical advances allow percutaneous administration. A new hand-held device is now approved for use within the United States. Cryoneurolysis has been used to treat postoperative and chronic pain states as well as spasticity. Expert commentary: Changes in the US healthcare system such as a push for the reduction of opioid use and the incorporation of Diagnostic Related Group codes, as well as recent technological advances including a handheld unit that allows for treatment of superficial nerves while protecting the skin from damage, may contribute to the resurgence of cryoneurolysis for the treatment of peripheral nerves. ARTICLE HISTORY

show abstract

Section: Safety Of Cryoneurolysismentioning

confidence: 96%

Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves

Ilfeld

Preciado

Trescot

2016

Expert Review of Medical Devices

View full text Add to dashboard Cite

show abstract

“…Previous reports have demonstrated that repeated exposure of cancer cells to thermal treatment results in increased cell death [18,38]. As such, thermal ablation is typically applied as a monotherapy in a repeat exposure protocol.…”

Section: Impact Of Dual Thermal Ablationmentioning

confidence: 99%

“…Further, unlike other treatment strategies, molecular drug resistance can be overcome with thermal injury [10]. Although cryoablation is not a mainstream thermal technique for PaCa, it is a primary treatment option in other cancers [6,[16][17][18][19][20][21][22]. In 2008, the American Urological Association published a best practice statement on prostate cancer, recommending cryosurgery as a primary treatment option [23].…”

Section: Introductionmentioning

confidence: 99%

Dual thermal ablation of pancreatic cancer cells as an improved combinatorial treatment strategy

Baumann¹,

Baust²,

Snyder³

et al. 2017

Liver Pancreat Sci

View full text Add to dashboard Cite

Pancreatic cancer (PaCa) is one of the leading causes of cancer related deaths in the world today. It is estimated that 95% of patients diagnosed with PaCa will die because of limited treatment options. As standard treatments have not yielded an improvement in patient outcome, alternative approaches, such as thermal ablation, may offer a new treatment path. We previously reported the lethal temperatures necessary for PaCa ablation for both freeze and heat based treatments. In this study, we investigated the response of PaCa cells in vitro to a combination treatment of heating and freezing, dual thermal ablation (DTA), in an effort to further improve ablation efficacy.PaCa cell lines, PANC-1 and BxPC-3, were subjected to heating (45 to 50°C), freezing (-10 to -20°C), or DTA exposure. Post-exposure viability was assessed over a 7-day recovery interval. Modes of cell death were analyzed using fluorescence microscopy and flow cytometry.Our results indicated that in comparison to single thermal modalities, DTA resulted in greater cell destruction at a more rapid rate. Specifically, -15°C had a moderate impact on day one cell viability (PANC-1=80%; BxPC-3=21%) and 50°C (PANC-1=74%; BxPC-3=18%) caused a slow decline in cell number post-treatment. The combination of these treatments resulted in an increased cell death one-day post-treatment (PANC-1=28%; BxPC-3=5%) and achieved complete cell destruction within three days. Overall, these data suggest that a combination of heat and freeze ablation, DTA, may provide for an improved treatment strategy for PaCa.

show abstract

“…For example, while osteocytes will definitely die in this temperature range, tissue from a healthy liver, kidney or prostate can survive one-time application of such a temperature. Compared to healthy cells, tumor cells have greater and variable resistance to cold [9]. Moreover, fibroblasts and collagen fibers usually survive a freezing process [10].…”

Section: Mechanism Of Action and Cryobiologymentioning

confidence: 99%

Current Technique and Application of Percutaneous Cryotherapy

Mahnken

König

Figiel

2018

Fortschr Röntgenstr

View full text Add to dashboard Cite

ABSTR AC TPurpose Local ablative therapies have become an established treatment option in interventional oncology. Radiofrequency ablation (RFA) and microwave ablation (MWA) are a standard of care in the treatment of hepatocellular carcinoma (HCC). Currently, there is an increasing interest in cryotherapy, one of the oldest ablation techniques. It has some unique characteristics with regard to technology and mechanism of action.Materials and Methods A systematic literature search using the terms cryotherapy, cryosurgery and cryoablation was performed. Selected studies are presented dealing with the mechanism of action, cryobiology and clinical use of percutaneous, image-guided cryoablation. Recent developments and perspectives are presented.Results Cryotherapy is increasingly used and has been included in guidelines for selected tumor entities such as renal cell carcinoma. Cryo-immunotherapy and combination treatments are future areas of interest.Conclusion Cryoabalation may be used in many indications.Its major advantages are its unique visualization and the anesthesiologic effects of cold. While there are only a few prospectively randomized trials, the existing data on the use of cryoablation is promising. Its use appears to be justified in selected tumors, oligometastatic patients and for palliative indications.

show abstract

Experimental cryosurgery investigations in vivo

Cited by 252 publications

References 198 publications

Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves

Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves

Dual thermal ablation of pancreatic cancer cells as an improved combinatorial treatment strategy

Current Technique and Application of Percutaneous Cryotherapy

Contact Info

Product

Resources

About