Hypothalamus–pituitary–adrenal axis activity and the subsequent response to chronic stress differ depending upon life history stage

Lattin, Christine R.; Bauer, Carolyn M.; Bruijn, Robert de; Romero, L. Michael

doi:10.1016/j.ygcen.2012.07.013

Cited by 80 publications

(71 citation statements)

References 59 publications

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“…Contrary to predictions of the behavioral hypothesis (Table 1), whole-brain GR was not lower during late breeding than during prebreeding, although House Sparrows attenuate adrenal sensitivity and the CORT response to stressors later in the breeding season (Lattin et al 2012a). Consequently, down-regulation of stressinduced behaviors may occur at the level of hormone secretion VoL.…”

Section: Discussionmentioning

confidence: 61%

“…These data suggest that breeding House Sparrows were less sensitive to the behavioral effects of stress-induced CORT. Although stress-induced CORT is high in House Sparrows during breeding, negative feedback is also high (Lattin et al 2012a), which means that breeding House Sparrows are able to mount a robust stress response but shut it down quickly, before it can interfere with reproduction. Therefore, FiG.…”

Section: Discussionmentioning

confidence: 99%

“…All molting birds were molting primary feathers (range: P3-P9). We confirmed breeding stage by inspecting cloacal protuberances and beak color (in males) and brood patches (in females), and by inspecting and weighing whole gonads after sacrifice (for additional information, see Lattin et al 2012a). House Sparrows were captured at bird feeders in Medford (42.4183°N, 71.1067°W) and Somerville, Massachusetts (42.3875°N, 71.1000°W), using mist nets and Potter traps.…”

Section: Study Subjects and Chemical Adrenalectomy-we Captured Freelmentioning

confidence: 99%

“…We also examined CORT receptor binding in the hippocampus, an area involved in CORT negative feedback regulation in mammals (Jacobson andSapolsky 1991, Jacobson 2005) and in CORT-sensitive memory formation and storage in birds (Pravosudov 2003(Pravosudov , 2005Roth et al 2012). House Sparrows show seasonal patterns in CORT concentrations similar to those in many other seasonally breeding vertebrates (Romero et al 2006, Lattin et al 2012a; furthermore, because their CORT receptors have been fully characterized in both brain (Breuner and Orchinik 2009) and gonads (Lattin et al 2012b), they are an excellent subject for this type of study.…”

mentioning

confidence: 99%

“…On the basis of the preparative hypothesis, we expected to see increased whole-brain and gonadal sensitivity to baseline and/or stress-induced CORT (and, therefore, increased GR and/ or MR binding) during the pre-egg-laying period (Table 1), which is associated with a number of predictable stressors, as described above. Our predictions for hippocampal binding were based on evidence that avian hippocampus is homologous to mammalian hippocampus (Colombo and Broadbent 2000) and on the results of a recent study that showed seasonal variation in negative feedback regulation in House Sparrows (Lattin et al 2012a). If avian hippocampus is involved in negative feedback regulation, as it is At baseline concentrations, the glucocorticoid hormone corticosterone (CORT) helps wild birds regulate metabolism and activity levels; in response to environmental perturbations, secretion of this hormone increases, and it plays a key role in regulating energy, immune function, and reproduction during the physiological stress response (Sapolsky et al 2000).…”

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confidence: 99%

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Seasonal variation in corticosterone receptor binding in brain, hippocampus, and gonads in House Sparrows (Passer domesticus)

Lattin

Romero

2013

The Auk

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Study Subjects and Chemical Adrenalectomy-we Captured Freelmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Seasonal variation in corticosterone receptor binding in brain, hippocampus, and gonads in House Sparrows (Passer domesticus)

Lattin

Romero

2013

The Auk

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Comparing the Natural and Anthropogenic Sodium Channel Blockers Tetrodotoxin and Indoxacarb in Garter Snakes

et al. 2016

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Synthetic chemicals, such as pesticides, are used in a variety of ways in the agricultural industry. Anthropogenic chemicals pose a unique challenge to organisms because of the lack of evolutionary history between the chemical and the organism. However, research has shown that some organisms have a resistance to these synthetic chemicals due to their evolved resistance to a natural compound with a similar structure or mode of action. Indoxacarb (INDOX) is a relatively new pesticide with a similar mode of action to that of tetrodotoxin (TTX). Tetrodotoxin is a naturally occurring toxin that is used as an antipredator defense in the rough-skinned newt (Taricha granulosa). Some populations of the common garter snake (Thamnophis sirtalis) have developed a resistance to tetrodotoxin. Here, we investigated the correlation between TTX and INDOX resistance in snakes. We hypothesized that INDOX would induce a much higher stress response than the naturally occurring TTX. We injected each snake with tetrodotoxin (1 mass-adjusted mouse unit). We did the same with mass-adjusted units of INDOX. We measured corticosterone, testosterone, and bactericidal ability. Our results show an acute stress response to INDOX, but not TTX through an elevate corticosterone and innate immune response, although there was no difference in testosterone concentration. These results suggest that, although INDOX may have a similar mechanism of action, garter snakes do not react in a similar manner as to TTX. This research gives a physiological perspective on the differences between naturally occurring compounds and synthetic compounds.

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Chronic repeated exposure to weather‐related stimuli elicits few symptoms of chronic stress in captive molting and non‐molting European starlings (Sturnus vulgaris)

2017

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Repeated exposure to acute stressors causes dramatic changes in an animal's stress physiology and the cumulative effects are often called chronic stress. Recently we showed that short-term exposure to weather-related stimuli, such as temperature change, artificial precipitation, and food restriction, cause acute responses in captive European starlings (Sturnus vulgaris). Here, we examined the effect of repeated exposure to weather-related stressors on heart rate and corticosterone (CORT) of captive non-molting and molting European starlings. Four times every day for 3 weeks, birds were exposed to either 30 min of a subtle (3°C) decrease in temperature, a short bout of simulated rain, or 2 hr of food removal. The order and time of presentation were randomly assigned on each day. We found no differences in heart rate or heart rate variability. Furthermore, there were no changes in baseline CORT levels, CORT negative feedback efficacy, or maximal adrenal capacity. Mass increased across the experimental period only in molting birds. CORT responses to restraint were decreased in both groups following treatment, suggesting the birds had downregulated their responses to acute stress. Molting birds showed evidence of suppression of the HPA axis compared with non-molting birds, which is consistent with previous research. Overall, our data show that repeated exposure to weather-related stressors does not elicit most of the symptoms normally associated with chronic stress.

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Hypothalamus–pituitary–adrenal axis activity and the subsequent response to chronic stress differ depending upon life history stage

Cited by 80 publications

References 59 publications

Seasonal variation in corticosterone receptor binding in brain, hippocampus, and gonads in House Sparrows (Passer domesticus)

Seasonal variation in corticosterone receptor binding in brain, hippocampus, and gonads in House Sparrows (Passer domesticus)

Comparing the Natural and Anthropogenic Sodium Channel Blockers Tetrodotoxin and Indoxacarb in Garter Snakes

Chronic repeated exposure to weather‐related stimuli elicits few symptoms of chronic stress in captive molting and non‐molting European starlings (Sturnus vulgaris)

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