Hypothalamic laterality in regulating gonadotropic function: Unilateral hypothalamic lesion and ovarian compensatory hypertrophy

Fukuda, Masaru; Yamanouchi, Korehito; Nakano, Yumiko; Furuya, Hiroshi; Arai, Yasumasa

doi:10.1016/0304-3940(84)90404-x

Cited by 35 publications

(23 citation statements)

References 15 publications

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“…Furthermore, physiological data which suggested direct effect of cerebral structures on the ovary still before the demonstration of the multisynaptic pathway between the ovary and the brain, revealed functional asymmetry of the hypothalamus. Lesion of the anterior hypothalamus (Fukuda et al, 1984) on the right side suppressed the development of compensatory ovarian hypertrophy that follows unilateral ovariectomy. Similarly, rightsided lesion of the preoptic area (Moran et al, 1994) resulted in a decrease in the number of ova shed, and ovulation was completely blocked by implantation of atropine into the right anterior hypothalamus (Cruz et al, 1989).…”

Section: Discussionmentioning

confidence: 96%

Predominance of supraspinal innervation of the left ovary

Tóth

Wiesel

Boldogköi

et al. 2007

Microscopy Res & Technique

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In our previous studies using the viral transneuronal tracing technique we demonstrated the spinal and supraspinal components of the ovarian innervation. Since increasing number of data indicate the presence of morphological and functional laterality in the control of gonadal functions, we aimed to investigate whether cerebral structures trans-synaptically involved in the innervation of the ovary exhibit asymmetry or not. In one of the studies the left or the right ovary was injected with the red fluorescent protein expressing pseudorabies virus and the number of infected "red" autofluorescent neurons from the right and the left ovary was compared. In another study in order to have distinct labeling of cell groups connected with the right- and left-sided ovary in the same animal, a dual viral labeling was applied. The left- and right-sided ovary were inoculated with genetically engineered pseudorabies virus expressing a red fluorescent protein or a green fluorescent protein gene. Viral infection of brain nuclei including the dorsal vagal nucleus, caudal raphe nuclei, A5 noradrenergic cell group, hypothalamic paraventricular nucleus, from the left ovary in each case was enhanced when compared with labeling from the right gonad. Data suggest a predominance in the supraspinal innervation of the left ovary.

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Section: Discussionmentioning

confidence: 96%

Predominance of supraspinal innervation of the left ovary

Tóth

Wiesel

Boldogköi

et al. 2007

Microscopy Res & Technique

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“…Interestingly enough, some of these observations revealed functional asymmetry in the hypothalamic control of ovarian functions Halá sz, 1997, 2001). Lesion of the anterior hypothalamus on the right side has been reported to interfere with the development of compensatory ovarian hypertrophy that follows unilateral ovariectomy (Fukuda et al, 1984). A similar, right-sided lesion in the anterior hypothalamus prevented the hemiovariectomy-induced FSH rise (Nance et al, 1983).…”

Section: Functional Considerationsmentioning

confidence: 97%

Supraspinal connections of the ovary: Structural and functional aspects

Gerendai

Kocsis

Halász

2002

Microscopy Res & Technique

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This review summarizes our recent studies using the viral transneuronal tracing technique to identify sites in the central nervous system (CNS) that are connected with the ovary. A neurotropic virus (pseudorabies virus) was injected into the ovary and various times after the inoculation the spinal cord and brain were examined for virus-infected neurons identified by immunocytochemistry. Such neurons could be detected in well-defined cell groups of the spinal cord (intermediolateral cell column), brain stem (vagal nuclei, area postrema, parapyramidal nucleus, caudal raphe nuclei, A1, A5, A7 noradrenergic cell groups, locus coeruleus, Barrington's nucleus, periaqueductal gray), hypothalamus (paraventricular nucleus, anterior hypothalamus, arcuate nucleus, zona incerta), and, at longer survival time, in some telencephalic structures (amygdala, bed nucleus of the stria terminalis). These findings provided the first neuromorphological evidence for the existence of a multisynaptic neuronal pathway between the brain and the ovary presumably involved in the neuronal control of the organ. The observations indicate that there is a significant overlap of CNS structures connected with the ovary, the testis, other organs and organ systems, suggesting similar neuronal circuitries of the autonomic nervous system innervating the different organs. The known descending neuronal connections between the CNS structures labeled from the ovary by the viral transneuronal tracing technique and the findings suggesting a pituitary independent interplay between certain cerebral structures such as the hypothalamus, the amygdala, and the ovary are also summarized in this review.

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“…The OCH% is calculated on the basis of the removed ovarian weight at the time of hemi-ovariectomy (Fukuda et al 1984, Baligar & Kaliwal 2004. However, this method could not be directly applied to our present experiment because ovarian weight showed a marked increase during the developmental period, and because we could not preclude the possibility that TCDD itself affected ovarian development.…”

Section: Figurementioning

confidence: 97%

“…When rats were hemi-ovariectomized, the remaining ovary showed compensatory hypertrophy with a twofold increase in its weight as well as hyperovulation, and this phenomenon was considered to be induced by an increase in the secretion of gonadotropins and/or direct neural regulation via vagus nerves (Chavez et al 1987). The right side of the medial anterior hypothalamus is considered to be responsible for predominantly regulating OCH, because a unilateral lesion placed in the right side, but not in the left side of this region suppresses OCH (Fukuda et al 1984). The maturation of the hypothalamus, ovary and pituitary are prerequisites for the onset of OCH, indicating that the negative feedback of estrogen and the GnRH-surge secretion cooperatively functions.…”

Section: Figurementioning

confidence: 99%

Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring

Kakeyama

Sone

Tohyama

2008

Journal of Endocrinology

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Exposure to 2,3,7, during the fetal and neonatal periods has been indicated to alter the development of the offspring later in life. In this study, we determined whether perinatal exposure to a low dose of TCDD affects the onset of puberty in the female offspring of Long-Evans hooded rats. On day 15 of gestation, pregnant female rats were administered TCDD by gavage at a single dose of 0 (vehicle), 200, or 800 ng/kg b.w. In the female offspring born to dams administered with TCDD at either 200 or 800 ng/kg b.w., the vaginal opening and first estrus occurred w4-7 days earlier than in the offspring born to vehicle-treated animals. The ovarian weight gain was also accelerated following exposure to TCDD in a dose-dependent manner. We next examined the ovarian compensatory hypertrophy (OCH) as an indicator of the maturation of the LH/GnRH-generating system in the pituitary and the hypothalamus. Exposure to TCDD accelerated the onset of OCH in the female offspring in a dose-dependent manner. In particular, in the offspring born to the dams exposed to TCDD at 800 ng/kg b.w., hypertrophy, which is characterized by hyperovulation and a marked increase in the weight of the remaining ovary after hemi-ovariectomy, was observed on postnatal days 27-30, which was 10 days earlier than in the offspring born to the vehicle-treated dams. These results indicate that perinatal exposure to a low dose of TCDD induces precocious puberty, including early maturation of the hypothalamic-pituitary axis, the gonads and genitals, in female Long-Evans hooded rats.

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Hypothalamic laterality in regulating gonadotropic function: Unilateral hypothalamic lesion and ovarian compensatory hypertrophy

Cited by 35 publications

References 15 publications

Predominance of supraspinal innervation of the left ovary

Predominance of supraspinal innervation of the left ovary

Supraspinal connections of the ovary: Structural and functional aspects

Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring

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