Supraspinal connections of the ovary: Structural and functional aspects

Gerendai, Ida; Kocsis, Krisztián; Halász, Béla

doi:10.1002/jemt.10225

Cited by 49 publications

(31 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of cerebral cell groups we found labeled are known to have direct synaptic contact with the sympathetic or parasympathetic preganglionic neurons and/or the vagal nuclei (for details and references, see Gerendai et al, 2002).…”

Section: Distribution Of Virus-infected Neuronsmentioning

confidence: 99%

Comparison of transsynaptic viral labeling of central nervous system structures from the uterine horn in virgin, pregnant, and lactating rats

Wiesel

Tóth

Boldogkői

et al. 2004

Microscopy Res & Technique

Self Cite

View full text Add to dashboard Cite

Using the transneuronal viral tracing method, the central nervous system (CNS) connections of the uterine horn were studied in virgin, pregnant, and in lactating rats. The frequency of viral labeling in the brain and the distribution of virus-infected neurons from the uterine horn were compared among groups. There was a marked difference in the frequency of viral labeling in the brain stem. In virgin rats more than half of the brain stems (5 out of 9) were labeled. In contrast, in pregnant animals viral-labeled neurons were detected in only a few cases (3 out of 16) and almost each brain stem of the lactating group was labeled (12 out of 13). A similar, less marked difference was observed in the hypothalamus. The pattern of distribution of infected neurons was similar in each group. In the brain stem, the nucleus of the solitary tract, dorsal motor nucleus of the vagus, area postrema, gigantocellular and paragigantocellular nucleus, ventrolateral medulla, A5 cell group, and caudal raphe nuclei were the most frequently labeled structures. In the diencephalon, viral-infected neurons were detected primarily in the hypothalamic paraventricular nucleus. The telencephalon was devoid of infected cells. Data suggest that the CNS control of the uterine horn varies depending on reproductive status. The low frequency of brain labeling in pregnant rats may be related to the almost complete lack of sympathetic fibers in the uterus prior to parturition and the very high frequency of labeling in lactating animals to the postpartum hyperinnervation of the uterus.

show abstract

Section: Distribution Of Virus-infected Neuronsmentioning

confidence: 99%

Comparison of transsynaptic viral labeling of central nervous system structures from the uterine horn in virgin, pregnant, and lactating rats

Wiesel

Tóth

Boldogkői

et al. 2004

Microscopy Res & Technique

Self Cite

View full text Add to dashboard Cite

show abstract

“…The rise in LH can already be seen 3 min after ejaculation (13). Spontaneous ovulatory animals with also the potential to induce a reflex ovulation (facultative reflex ovulators), like rats, have autonomic nerves (parasympathetic and sympathetic) and visceral sensory fibers innervating the ovary (14,15). Copulation in the spontaneous ovulating rats can trigger or hasten ovulation and cervicovaginal stimulation increases the output of eggs (12,16).…”

Section: Neuronal Pathwaysmentioning

confidence: 99%

“…Copulation in the spontaneous ovulating rats can trigger or hasten ovulation and cervicovaginal stimulation increases the output of eggs (12,16). Furthermore, it seems that the ovarian nerves can influence the hormonal activity and interfere with cyclicity (14). Transsection of the efferent parasympathetic fibers in rats (vagotomy) altered the length of the estrous cycle (17) and caused a delay of the onset of puberty (18).…”

Section: Neuronal Pathwaysmentioning

confidence: 99%

Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

Hendriks¹,

König

Soleman

et al. 2013

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Little is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. Design: Prospective case-control study (2008)(2009)(2010). Methods: Ten PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation. Results: All PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P!0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (PZ0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, PZ0.67). None of the ovarian hormones (estradiol, progesterone, anti-Mü llerian hormone, inhibin B, androstenedione and testosterone) changed in either group. Conclusions: Ovarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic-pituitary system is the most reasonable explanation.

show abstract

“…The vagus nerve is one of the neural pathways involved in regulating ovarian functions [1-9] Gerendai and collaborator's provided the first morphological evidence of a multi-synaptic neural pathway between the ovary and the central nervous system (CNS), showing that the vagus nerve forms part of such neural connection [6,7,10]. Unilateral ovariectomy (ULO) is an experimental tool used to analyze the existence of functional asymmetry between the ovaries.…”

Section: Introductionmentioning

confidence: 99%

“…Burden and Lawrence [1] suggested that the ovarian innervation modulates ovarian functions. Ample experimental evidence supporting the idea that ovarian functions are modulated by at least two different neural pathways, the noradrenergic system (via the superior ovarian nerve and the ovarian plexus) and the parasympathetic system (via the vagus nerve), have been published [6,7,9,17-23]. …”

Section: Introductionmentioning

confidence: 99%

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

Morales¹,

Ricardo²,

Bolanos³

et al. 2007

Reprod Biol Endocrinol

View full text Add to dashboard Cite

The present study evaluates the participation of the vagus nerve in pre-pubertal rats with unilateral ovariectomy on puberty onset, and on progesterone, testosterone and estradiol serum levels, and the compensatory responses of the ovary. Unilateral vagotomy did not modify the onset of puberty in unilaterally ovariectomized rats. Ovulation rates of animals with the left vagus nerve sectioned and the left ovary in-situ was lower than in rats with only unilateral ovariectomy. Sectioning the left vagus to 32-day old rats with the left ovary in-situ resulted in lower compensatory ovarian hypertrophy than in rats with right unilateral ovariectomy. Twenty-eight or 32-day old animals with sectioning of the right vagus nerve and the right ovary in situ showed higher compensatory ovulation. Twenty-eight -day old rats with the right ovary in situ had higher progesterone and testosterone levels than animals of the same age with the left ovary in-situ. Compared to animals with the right ovary in situ, animals treated at 32-days of age, sectioning the ipsi-lateral vagus nerve resulted in higher progesterone levels. Higher progesterone levels were observed in 28- and 32 days old rats with the left ovary in situ and left vagus nerve sectioned. Thirty-two day old animals with the right ovary in situ and right vagus nerve sectioned had higher progesterone levels than rats of the same age with the left ovary in situ and left vagus nerve sectioned. Left vagotomy to 28-day old rats with the left ovary in situ resulted in higher testosterone levels, a reverse response to that observed in animals with sectioning of the right vagus and the right ovary in situ. Thirty-two day old rats with the left ovary in situ and left vagus nerve sectioned showed lower testosterone levels than animals without vagotomy and with the left ovary in situ.Twenty-eight -day old animals with the left vagus sectioned and left ovary in situ had lower estradiol serum levels than rats without unilateral vagotomy, a response similar to that observed in 32-day old rats with the right ovary in situ and right vagus nerve sectioned. Present results suggest an asymmetric regulation of steroid hormones secretion by the vagus nerve innervations in animals with unilateral ovariectomy, and those differences in testosterone serum levels observed are associated to the ovary remaining in-situ, vagal innervation and age when the animals were treated.

show abstract

Supraspinal connections of the ovary: Structural and functional aspects

Cited by 49 publications

References 81 publications

Comparison of transsynaptic viral labeling of central nervous system structures from the uterine horn in virgin, pregnant, and lactating rats

Comparison of transsynaptic viral labeling of central nervous system structures from the uterine horn in virgin, pregnant, and lactating rats

Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

Contact Info

Product

Resources

About