No abstract

The information available at present clearly indicates that asymmetry exists from the level of elementary particles to the human cerebral cortex, the latest stage of evolution. Cerebral lateralization is one of the well-known asymmetries. This paper summarizes the data published in the past decades on the asymmetry of the neuroendocrine system. The information on the sided-differences between the gonads, adrenals, and thyroid lobes and that on the lateralization of hypothalamic, limbic, and other brain structures participating in the control of the endocrine glands as well as relevant clinical observations are reviewed here. The innervation of the peripheral endocrine glands is also briefly summarized because the afferent and efferent fibers of these glands may represent one part of the pathway involved in neuroendocrine asymmetry. The data reviewed clearly indicate that some kind of asymmetry (morphological, biochemical, physiological, pathological) is evident at different levels of the neuroendocrine system (at limbic, hypothalamic, peripheral endocrine glands and their innervation) and there are species, sex, and age differences. Most of the information accumulated deals with the CNS-gonadal system. A majority of the observations suggest that in both male and female rats there is a predominance of the right half of brain structures controlling gonadal function. The asymmetry, however, is not restricted to CNS structures: it also exists at the level of the gonads, including their innervation. It appears that the characteristic pattern of the CNS-gonadal system becomes fixed only after sexual maturation. Very few reports are available suggesting some kind of asymmetry of the CNS-adrenal cortex and the CNS-thyroid system. There are convincing findings consistent with the view that in addition to the hypothalamo-adenohypophyseal system acting via the general circulation on the peripheral endocrine glands, there is also a pure neural link between the CNS and the gonads, the CNS and the adrenal gland, and also between the CNS and the thyroid. This link contains afferent and efferent pathways and is able to modulate the functional activity or the responsiveness of the gland. It may also serve as a neural reflex arc. It is assumed that the neuroendocrine asymmetry expresses itself through (i) hypophysiotrophic neurohormones and hormones of the peripheral endocrine glands, (ii) neural pathways, or (iii) a combination of (i) and (ii). The authors hope that this publication, in addition to providing an overview, will also stimulate research, both basic and clinical, in this exciting area of neuroendocrinology.

In the present investigations the viral transneuronal labeling method, which is able to reveal hierarchial chains of central nervous system (CNS) neurons, was applied to identify sites in the CNS connected with the ovary and presumably involved in the control of ovarian functions. Pseudorabies virus was injected into the ovaries of rats and a few days later (at various times after the injection) the spinal cord and brain were examined for virus-infected neurons from the ovary. The virus-labeled nerve cells were identified by immunocytochemistry using polyclonal antiviral antibody. Virus-labeled neurons were detected both in the spinal cord and the brain. In the spinal cord such elements were observed in the intermediolateral cell column, in the dorsal horn close to the marginal zone and in the central autonomic nucleus. In the medulla oblongata and pons, neurons of several nuclei and cell groups (area postrema, nucleus of the solitary tract, dorsal vagal complex, nucleus ambiguus, paragigantocellular nucleus, parapyramidal nucleus, A1, A5 and A7 cell groups, caudal raphe nuclei, locus ceruleus, subceruleus nucleus, Barrington’s nucleus, Kölliker-Fuse nucleus) were found to be transneuronally labeled. In the mesencephalon, the ventrolateral part of the periaqueductal gray matter contained virus-labeled neurons. In the diencephalon, a very intensive cell body labeling was observed in the hypothalamic paraventricular nucleus and a few virus-infected neurons could be detected in the lateral and dorsal hypothalamus, in the arcuate nucleus, zona incerta, perifornical area and in the anterior hypothalamus. Concerning the telencephalic structures, virus-labeled cells were found in the bed nucleus of the stria terminalis and in the central amygdala nucleus. These findings provide the first neuromorphological evidence for the existence of a multisynaptic neuronal pathway between the ovary and the CNS, and give a detailed account of the structures involved in this pathway.

No abstract