Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats

Souza, Priscila de; Gasparotto, Arquimedes; Crestani, Sandra; Stefanello, Maria Élida Alves; Marques, Maria Consuelo Andrade; Silva-Santos, José Eduardo da; Kassuya, Cândida Aparecida Leite

doi:10.1016/j.phymed.2011.02.005

Cited by 66 publications

(46 citation statements)

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“…Artemetin has anti-inflammatory (Sertie, Basile, Panizza, Matida, & Zelnik, 1990), antiedematogenic (Bayeux, Fernandes, Foglio, & Carvalho, 2002), antioxidant (Dugas et al, 2000), and hypotensive properties (de Souza et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Ifeanacho

Ikewuchi

2016

Food Science & Nutrition

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The profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii was investigated using gas chromatography coupled with flame ionization detector. The leaves and stems had high flavonoids and benzoic acid derivatives content, and moderate levels of lignans and hydroxycinnamates. Twenty-eight known flavonoids were detected, which consisted mainly of kaempferol (41.93% in leaves and 47.97% in stems), (+)-catechin (17.12% in leaves and 16.11% in stems), quercetin (13.83% in leaves and 9.39% in stems), luteolin (7.34% in leaves and 7.71% in stems), and artemetin (6.53% in leaves and 4.83% in stems). Of the six known hydroxycinnamates detected, chlorogenic acid (80.79% in leaves and 87.56% in stems) and caffeic acid (18.98% in leaves and 12.30% in stems) were the most abundant, while arctigenin (77.81% in leaves and 83.40% in stems) and retusin (13.82% in leaves and 10.59% in stems) were the most abundant of the nine known lignans detected. Twelve known benzoic acid derivatives were detected, consisting mainly of ellagic acid (65.44% in leaves and 72.89% in stems), p-hydroxybenzoic acid (25.10% in leaves and 18.95% in stems), and vanillic acid (8.80% in leaves and 7.30% in stems). The rich phytochemical profile of the leaves and stems is an indication of their ability to serve as sources of nutraceuticals. K E Y W O R D Sflavonoids, hydroxycinnamates, lignans, Pandiaka heudelotii, phenolic acids

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Section: Discussionmentioning

confidence: 99%

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Ifeanacho

Ikewuchi

2016

Food Science & Nutrition

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“…Quant aux De Souza et al, (2011), ils ont montré que cette molécule isolée de Achillea millefolium a réduit la pression artérielle moyenne des rats. D'ailleurs, l'huile essentielle de cette plante a montré une activité antifongique et antioxydante très importante (Alilou et al, 2014b).…”

Section: Activité Antifongique Des Flavones D'asteriscus Graveolens Sunclassified

Activite Antifongique Des Flavonoïdes Isoles De La Plante Asteriscus Graveolens Subsp. Odorus (Schousb.) Greuter

Alilou

Bencharki

Talbi

et al. 2016

ESJ

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A phenol acid and three flavones isolated from the plant Asteriscus graveolens subsp. odorus were tested against three fungi: Botrytis cinerea, Penicillium digitatum and Penicillium expansum. Using the method of incorporation of products in a PDA, a high sensitivity of Botrytis cinerea to caffeic acid and nevadensine was observed. Penicillium digitatum is the sensitive to luteolin, as to Penicillium expansum, it marks a sensitivity to artemetin. The efficacy of the tested molecules could be the subject of an investigation and exploitation in the integrated fight against the three tested fungi that cause a lot of damage to fruits and vegetables post-harvest.Keywords: Antifungal activity, Asteriscus graveolens subsp. odorus, pathogenic fungi Flavonoids RésuméUn acide phénol et trois flavones isolées de la plante Asteriscus graveolens subsp. odorus ont été testés contre les trois champignons : Botrytis cinerea, Penicillium digitatum et Penicillium expansum. En utilisant la méthode d'incorporation des produits dans un milieu PDA, une forte sensibilité du Botrytis cinerea à l'acide caféique et à la névadensine a été European Scientific Journal April 2016 edition vol.12, No.12 ISSN: 1857 -7881 (Print) e -ISSN 1857 259 observé. Le Penicillium digitatum est sensible à la lutéoline, quant au Penicillium expansum, il marque une sensibilité à l'artemétine. L'efficacité des molécules testées pourrait être le sujet d'une investigation et une exploitation dans la lutte intégrée contre les trois champignons testés qui causent beaucoup de dégâts sur les fruits et légumes en post-récolte.

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“…Recent studies have shown that flavonoids have antihypertensive activity due to the inhibitory action of the angiotensin converting enzyme (ACE) [2]. ACE inhibitors prevent the formation of angiotensin II.…”

Section: Introductionmentioning

confidence: 99%

<strong>Molecular Docking study of the flavonoids quercetin and artemetin front the angiotensin-converting enzyme</strong>

Delmondes

2017

Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd Edition

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Abstract:Phenolic compounds, such as flavonoids, have aroused great scientific interest due to their diverse pharmacological activities, such as antioxidant, anti-inflammatory, anticancer and antihypertensive, among others. Several studies suggest the mechanisms responsible for the antihypertensive activity of flavonoids, and among them is the inhibitory activity of the angiotensinconverting enzyme (ACE). Thus, the objective of the present study was to perform a molecular docking study of flavonoids quercetin and artemetin against ACE, aiming at a better understanding of the interaction of these flavonoids with the enzyme. The crystallographic structure of the enzymatic target ACE was obtained from the Protein Data Bank database [PDB: 1UZE]. The molecular docking study was performed using Autodock 4.0 software. Gasteiger charge and polar hydrogens needed for the power calculations were added to the enzyme, with the water molecules removed. The grid was positioned in the catalytic region of the enzyme with dimensions on the X-, Y-and Z-axis at 32 Å 30 Å and 38 Å, respectively, spacing 0.375 Å. The Lamarckian Genetic algorithm was chosen to search for the best conformations with 100 runs for each binder. During the search, the enzyme was held rigid and the ligands were kept flexible. Both artemetin and quercetin interacted with the active site of the enzyme attractively. With docking energy at -6.89 kcal/mol, artemetin was more stable in complex with the active site of the enzyme ACE, whereas quercetin presented docking energy at -6.63 kcal/mol. Both ligands interacted by hydrogen bonds with amino acids GLU 384, TYR 520, HIS 513, HIS 353, GLN 281, LYS 511 and the Zn ion. The study showed that the methodology used in the present study can be well used for the understanding of the interaction of pharmacologically active compounds with target enzymes, saving time and resources. __________________________________________________________________________________ Keywords: Molecular docking; flavonoides; angiotensin-converting enzyme Graphical Abstract:MOL2NET, 2017, 3, http://sciforum.net/conference/mol2net-03 2 Introduction:

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Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats

Cited by 66 publications

References 44 publications

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Activite Antifongique Des Flavonoïdes Isoles De La Plante Asteriscus Graveolens Subsp. Odorus (Schousb.) Greuter

<strong>Molecular Docking study of the flavonoids quercetin and artemetin front the angiotensin-converting enzyme</strong>

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