Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats

Abreu, Iracelle Carvalho; Marinho, Alex S.S.; Paes, Antonio M A; Freire, Sonia; Olea, Roberto Sigfrido Gallegos; Borges, Marilene O. R.; Borges, Antônio Carlos Romão

doi:10.1016/j.fitote.2003.07.002

Cited by 42 publications

(30 citation statements)

References 11 publications

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“…(batata-de-tiú) apresentou atividade antibacteriana (Lima et al, 2006) e moluscicida (Santos & Sant'Ana, 1999). Jatropha gossypiifolia reduziu significativamente a pressão sanguínea sistólica em ratos (Abreu et al, 2003). No entanto, nenhum trabalho relacionado às propriedades hipolipidêmicas e anorexígenas de plantas do gênero Jatropha foi encontrado.…”

Section: Em Nossa Senhora Do Livramento-mtunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:O presente trabalho verificou a utilização de plantas medicinais encontradas no Cerrado mato-grossense para o tratamento de hiperlipidemias e obesidade. Entrevistas com 180 pessoas acima de 50 anos foram realizadas em Nova Xavantina-MT. O questionário abordou nome popular, parte utilizada, forma de preparo e uso das espécies citadas, além de informações gerais sobre o uso de plantas. -Hil.). A folha foi a parte mais utilizada (46%) e o preparo das plantas ocorre principalmente por meio de infusão citado por 36,5% dos entrevistados. Apesar do uso popular destas plantas no combate as hiperlipidemias e obesidade, há necessidade de estudos fitoquímicos e farmacológicos que comprovem estas atividades, com vistas ao desenvolvimento de um fitoterápico.Unitermos: Levantamento etnobotânico, Nova Xavantina, plantas medicinais, anti-hiperlipidêmicas, anorexígenas, Cerrado.ABSTRACT: "Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil". This study checked the use of medicinal plants found in the Cerrado mato-grossense for the treatment of hyperlipidemia and obesity. Interviews with 180 people over 50 years were held in Nova Xavantina-MT. The questionnaire addressed popular name, part used, type of preparation and use of the species mentioned, beyond general information about the use of plants. The ten plants most cited were collected, identified and studied through a literature review. Most respondents (95.6%) said using medicinal plants regularly, while 71.5% of them inherited the knowledge of plants of parents and grandparents and 94.20% reported the use to advise youngsters. Furthermore, 93.6% attested that the plants are more effective than the drugs from pharmacy and 57% considered the strong effect of the same, i.e., they always solved health problems. Regarding adverse effects, 95.9% said they have never felt them after the use of plants. Of the respondents, 56.7% knew or had used medicinal plants in the treatment of hyperlipidemias and obesity, being cited 54 medicinal species belonging to 53 different genera and 38 families, with emphasis on Fabaceae (13%

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Section: Em Nossa Senhora Do Livramento-mtunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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“…After this process, the EEJg was fractioned using chloroform and water as solvent, obtaining the aqueous (AFJg) and chloroformic (CFJg) fractions, with a yield of 71 and 29%, respectively (Abreu et al, 2003;Silva et al, 2011).…”

Section: Preparation Of Ethanolic Extract and Fractionsmentioning

confidence: 99%

“…Additionally, Abreu et al (2003) observed the hypotensive effect of the ethanolic extract (EE) from the aerial parts of J. gossypiifolia L., which presented a significant, dose-dependent reduction, in the systolic blood pressure in non-anesthetized normotensive Wistar rats (NWR). The percentage of inhibition was 11 and 13% for groups treated orally with EE at 125 and 250 mg/kg/bw, respectively.…”

Section: Introductionmentioning

confidence: 99%

Effects of Jatropha gossypiifolia L. on the blood pressure and vascular reactivity of rats

Selma¹,

Iracelle²,

Maria³

et al. 2015

Afr. J. Pharm. Pharmacol.

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This work investigated the effects of the ethanolic extract (EEJg) of aerial parts of Jatropha gossypiifolia L. and its aqueous (AFJg) and chloroformic (CFJg) fractions on the blood pressure and vascular reactivity (VR) in normotensive Wistar rats (NWR) and spontaneously hypertensive rats (SHR). In anaesthetized NWR, the EEJg and its fractions reduced mean blood pressure (MAP). The oral administration of EEJg (100 mg/kg/bw), for 8 weeks, did not alter MAP and heart rate in the nonanesthetized SHR. VR was determined in mesenteric artery rings, with the EEJg and fractions inhibiting the contractile responses to noradrenaline (NA, 10 -9 to 10 -4 M) in NWR, but not in SHR. In addition, the CFJg inhibited the contractile response to calcium (CaCl 2 , 10 -6 to 10 -2 M). These results suggest that J. gossypiifolia L. has no effect on the hypertensive factors in SHR, which is a model of polygenic hypertension, but indicate the presence of substances with hypotensive activity, which act directly on the adrenoceptor and/or decrease calcium mobilization in NWR.

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“…The various chemical and pharmacological studies carried out with this species, including the demonstration of a significant hypotensive potential, have confirmed some of these traditional uses. However, some studies presenting signs of hepatic toxicity of the J. gossypiifolia have been published (Abreu et al, 2003;Kumar et al, 2006;Mariz et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…These data inform about the seriousness of the risk to health with the prolonged exposition to the EE of Jatropha gossypiifolia, considering that deaths occur in the second experimental dose already (135 mg/kg). This dose corresponds to that in which it was demonstrated experimentally the hipotensor effect of the plant (Abreu et al, 2003), thus being the one that would be near therapeutics, in case the specie should be validated as phytotherapeutic drug. Still pointing out the seriousness of these data, one should consider that the larger experimental dose (405 mg/kg), which killed more than 46% of the males treated, is less than twice the larger hipotensor dose of the extract published by Abreu et al (2003).…”

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confidence: 99%

Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats

Mariz¹,

Cerqueira²,

Araújo³

et al. 2012

Rev. bras. farmacogn.

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This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.

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Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats

Cited by 42 publications

References 11 publications

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Effects of Jatropha gossypiifolia L. on the blood pressure and vascular reactivity of rats

Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats

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