Hypopigmented Mycosis Fungoides

Se, Whitmore; Simmons-O'Brien, E; Fs, Rotter

doi:10.1001/archderm.1994.01690040080012

Cited by 82 publications

(41 citation statements)

References 14 publications

(1 reference statement)

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“…Most AA patients reported have hypopigmented MF with favorable prognosis. [11][12][13] Female sex appears to be a risk factor, particularly in AAs. Although only 46% of all patients were female, among AAs there were 81 women compared with 41 men, a ratio of 1.98:1.…”

Section: Discussionmentioning

confidence: 99%

Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides

Sun

Berthelot

et al. 2009

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides

Sun

Berthelot

et al. 2009

Journal of the American Academy of Dermatology

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“…Regarding hypopigmented mycosis fungoides. Whitmore et al [3] reported 3 African-American pa tients and concluded that the hypopigmented 362 Dermatology 1996; 192:360-363 K i k uch i/S h i m izu/N i sh ikawa lesions were related to the degenerative changes of melanocytes and their abnormal melanogenesis caused by a nonspecific re sponse to inflammation. In our case, there is no history of hereditary disorders, drug in take or hormonal abnormality associated with hyperpigmentation.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides with Marked Hyperpigmentation

Kikuchi

Shimizu

Nishikawa³

1996

Dermatology

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Pigmentary changes in mycosis fungoides are not rare. Although poikiloderma and hypopigmented skin lesions have often been reported in the literature, there are few cases of mycosis fungoides presenting as a hyperpigmented skin lesion. We present a 57-year-old Japanese male with mycosis fungoides whose skin lesions showed marked hyperpigmentation. The skin lesion initially appeared as an irregularly shaped itchy annular erythema with central pigmentation predominantly on his extremities. During our 5-year follow-up, these skin lesions gradually increased in size and number. The erythema extended peripherally and became elevated with marked hyperpigmentation. Histology revealed extreme elongation of the rete ridges with infiltration of atypical large lymphoid cells characteristic of mycosis fungoides and numerous melanin granules in both the epidermal melanocytes and dermal melanophages. Although the exact mechanism of the marked hyperpigmentation in the lesional skin of mycosis fungoides is not clear, we conclude that hyperpigmentation is one of the unique characteristics in mycosis fungoides, especially in non-white individuals.

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“…2,179 Misdiagnosis often leads to delays in diagnosis and treatment ranging from 7 months to 10 years from disease onset to histologic diagnosis. 199 There is usually a good response to therapy with psoralen plus ultraviolet A light, UVB light, and topical mechlorethamine, yet recurrences are common. 194 The overall prognosis is good and similar to that of nonhypopigmented stage 1a mycosis fungoides.…”

Section: Dermatofibrosarcoma Protuberansmentioning

confidence: 99%