Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides

Sun, Gongqin; Berthelot, Cindy; Li, Yafang; Glass, Donald A.; George, Dornechia E; Pandya, Amit G.; Kurzrock, Razelle; Duvic, Madeleine

doi:10.1016/j.jaad.2008.09.063

Cited by 76 publications

(52 citation statements)

References 14 publications

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“…However, DSS did not differ between the two groups ( Table 2), indicating that the difference in OS was attributable to age-associated health risks. Although several studies have shown that survival of patients with MF and SS may be linked to sex [15,19,29,33,43,44], we could not find the difference in survival between female and male patients ( Table 2).…”

Section: Survival According To Age Sex Ldh and Pscontrasting

confidence: 73%

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Prognosis of 100 Japanese patients with mycosis fungoides and Sézary syndrome

Suzuki

Ito

et al. 2010

Journal of Dermatological Science

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Section: Survival According To Age Sex Ldh and Pscontrasting

confidence: 73%

“…Because the prognosis of patients with MF and SS may be influenced by race or ethnicity [19,33] and because the treatment options available in Japan are somewhat different from those used in western countries, it is important to determine the prognosis of Japanese patients with MF and SS.…”

Section: Introductionmentioning

confidence: 99%

Prognosis of 100 Japanese patients with mycosis fungoides and Sézary syndrome

Suzuki

Ito

et al. 2010

Journal of Dermatological Science

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“…20s and 30s). [2][3][4] Multiple epidemiologic studies documented that the incidence of CTCL has increased by »3 fold in the last 25-30 years. 4,5 In the early disease stages, which can last for several years, MF presents as flat erythematous skin patches resembling benign inflammatory diseases, whereas in the later stages, MF cells gradually form plaques or tumors and may disseminate to the lymph nodes and internal organs.…”

Section: Introductionmentioning

confidence: 99%

Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines

et al. 2014

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Deregulation of STAT signaling has been implicated in the pathogenesis for a variety of cancers, including CTCL. Recent reports indicate that loss of STAT4 expression is an important prognostic marker for CTCL progression and is associated with the acquisition of T helper 2 cell phenotype by malignant cells. However, little is known about the molecular mechanism behind the downregulation of STAT4 in this cancer. In the current work we test the expression of STAT4 and STAT6 via RT-PCR and/or Western Blot in CTCL lesional skin samples and in immortalized patient-derived cell lines. In these malignant cell lines we correlate the expression of STAT4 and STAT6 with the T helper (Th) phenotype markers and test the effect of Histone Deacetylase (HDAC) inhibitors and siRNA-mediated knock down of miR-155 on STAT4 expression. Our findings demonstrate that STAT4 expression correlates with Th1 phenotype, while STAT6 is associated with the Th2 phenotype. Our results further document that STAT4 and STAT6 genes are inversely regulated in CTCL. Treatment with HDAC inhibitors upregulates STAT4 expression, while at the same time decreases STAT6 expression in MyLa cells. Also, siRNA-mediated knock down of miR-155 leads to upregulation in STAT4 expression in MyLa cells. In summary, our results suggest that loss of STAT4 expression and associated switch to Th2 phenotype during Mycosis Fungoides progression may be driven via aberrant histone acetylation and/or upregulation of oncogenic miR-155 microRNA.

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“…71% of patients presented with early-stage disease [9,10]. Women presented with early onset of MF before the age of 40 years more often than men [12].…”

Section: Mycosis Fungoidesmentioning

confidence: 99%