Skin cancer in skin of color

Gloster, Hugh Morris; Neal, Kenneth W.

doi:10.1016/j.jaad.2005.08.063

Cited by 570 publications

(555 citation statements)

References 171 publications

(472 reference statements)

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“…Development of BCC has been correlated with prolonged, intensive UV exposure, occurring commonly after the fifth decade of life. BCC is the most common skin cancer in Caucasians, Hispanics, Chinese and Japanese (Gloster et al 2006) and people with outdoor occupations, such as farmers, fishermen, and construction workers (Bader et al, 2014), as seen in our observation where most of the skin malignancy were in farmers.A retrospective study from India reported 51.6% as NMSCs, of which 83.9% were SCC and 16.1% as BCC. (Adinarayan et al, 2011) In dark-skinned people, SCC often occurs in sites that have not been exposed to the sun and is often aggressive.SCC in heavily pigmented skin often arises in association with scarring processes, a myriad of chronic dermatoses have been associated with malignant potential for SCC (Khuller G et al, 2014).…”

Section: Introductionsupporting

confidence: 65%

Profile of Skin Biopsies and Patterns of Skin Cancer in a Tertiary Care Center of Western Nepal

Kumar¹,

Shrestha²,

Pun³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Introductionsupporting

confidence: 65%

Profile of Skin Biopsies and Patterns of Skin Cancer in a Tertiary Care Center of Western Nepal

Kumar¹,

Shrestha²,

Pun³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…37 Furthermore, even though skin cancers are less frequent in nonwhite/darkly pigmented individuals, it is often associated with increased morbidity and mortality due to a lack of awareness of these diseases among these populations, associated with a delay in diagnosis. 23,[38][39][40][41][42][43][44][45] The latter is responsible for a 31% risk of metastasis among Hispanic and Afro-American patients, compared with a 4% risk in caucasian patients as reported by the Centers for Disease Control in Atlanta (U.S.A.) in 2012. The U.S. Census Bureau estimates that by the year 2050, 50% of the American population will be of Hispanic, Asian and Afro-American ancestry.…”

Section: Discussionmentioning

confidence: 99%

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

2013

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SummaryHarmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects are largely due to the degree of constitutive pigmentation of the skin. The latter can be objectively classified according to the individual typology angle (°ITA) based on colorimetric parameters. The physiological relevance of the ITA colorimetric classification was assessed in 3500 women living in various geographical areas. Furthermore, in order to understand the relationship between constitutive pigmentation and ultraviolet radiation (UVR) sensitivity, we worked on ex vivo human skin samples of different colour exposed to increasing UVR doses. For each sample we defined the biologically efficient dose (BED), based on the induction of sunburn cells, and analysed UVR-induced DNA damage (cyclobutane thymine dimers, CPD). We found a significant correlation between ITA and BED. We also found a correlation between ITA and DNA damage. As the epidermal basal layer also hosts melanocytes and in order to analyse the relationship between skin colour and DNA damage occurring specifically within this cell type, we performed double staining for CPD and tyrosinase-related protein (TRP) 1, a key enzyme in melanin synthesis. We found that DNA damage within melanocytes depends on ITA. Taken together our results may explain the higher risk of lighter skin types developing skin cancers, including melanoma, as well as the development of pigmentary disorders in moderately pigmented skin. They show that skin classification based on ITA is physiologically relevant (as it correlates with constitutive pigmentation) and further support the concept of a more personalized approach to photoprotection that corresponds to a particular skin colour type's sensitivity to solar UVR.What's already known about this topic?• Sun exposure sensitivity is largely dependent on the degree of skin constitutive pigmentation.What does this study add?• The individual typology angle (ITA)-based skin colour classification correlates with constitutive pigmentation and is physiologically relevant in different geographical areas.• It may help identify differential responses to ultraviolet radiation (UVR) exposure that correspond to particular skin colour type's UVR sensitivities.• It supports the concept of personalized photoprotection.Harmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects is largely dependent on the degree of constitutive pigmentation of the skin.1-6 Human skin colour is determined by the total quantity of melanin, the proportion between the brown-black eumelanin

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“…The most common nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which start in either the basal cells or squamous cells located at the base of the outer layer of skin (epidermis) [1]. The majority of NMSCs develop on sun-exposed areas in white populations [2]. Risk factors for the development of SCC in darkly pigmented individuals, as in cases of people of the subcontinent, are chronic scarring and areas of chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Development of BCC has been correlated with prolonged, intensive Ultra violet rays exposure, with BCC occurring most commonly after the fifth decade of life. More than 90 % of NMSC occur in the head and neck region with the face being the commonest site [2].…”

Section: Introductionmentioning

confidence: 99%

Pattern of Nonmelanoma Skin Cancers in Sikkim, India: A 3-year Clinicopathological Review

Baruah

Sengupta

Kesari

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Basal cell carcinoma (BCC) and Squamous cell carcinoma (SCC), in combination, are referred to as Nonmelanoma skin cancers (NMSCs). NMSC has not been extensively studied in the population of the North eastern India as it has been done in the rest of India. This study was performed to understand the pattern of NMSCs in head and neck region in Sikkimese population. The present study is a retrospective analysis of NMSC of head and neck region that presented to the Department of ENT, Sikkim Manipal Institute of Medical sciences (SMIMS), a tertiary care center in Gangtok, Sikkim from July 2009 to July 2012. They were reviewed according to age, gender, site of involvement and histological types. Of the thirty-seven cases of NMSC analyzed during the 3 year study period, 24 cases were SCC and 13 cases were BCC. The most common age group for SCC was 40-50 years and BCC was 61-70 years. The most common site for both SCC and BCC was the upper lip. For SCC, the most common histologically type was well-differentiated and for BCC, it was the solid type. NMSCs comprise a small but significant proportion of all skin cancer patients in the world. SCC is the commonest variety unlike in western countries. The importance of understanding the risk factors as well as studying the frequency of histopathological patterns can help in the overall prognostic outlook for patients and also in planning an effective management.

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Skin cancer in skin of color

Cited by 570 publications

References 171 publications

Profile of Skin Biopsies and Patterns of Skin Cancer in a Tertiary Care Center of Western Nepal

Profile of Skin Biopsies and Patterns of Skin Cancer in a Tertiary Care Center of Western Nepal

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

Pattern of Nonmelanoma Skin Cancers in Sikkim, India: A 3-year Clinicopathological Review

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