Hypomagnesemic down-regulation of L-type Ca2+ channel in cardiomyocyte as an arrhythmogenic substrate in rats

Shimaoka, Toru; Wang, Yan; Miyamoto, Masaki; Miyamoto, Shinj̀i; Ono, Katsushige

doi:10.1016/j.pathophys.2015.01.002

Cited by 5 publications

(6 citation statements)

References 24 publications

(33 reference statements)

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“…Within these compartments, magnesium binds to chromatin and nucleic acid, matrix adeninephosphonucleotides and intermembrane proteins, and ribonuclear proteins and phospholipids, respectively [36] [37]. In the heart, it is certainly recognized that hypomagnesemia is associated with a variety of arrhythmias in clinical and experimental studies [38]. Myocardium, reduced Mg levels could represent a common link between these adverse cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction; Magnesium, because it is important in the cardiac metabolism; and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase How to cite this paper: Mantuano, A., Barroso, R.C., Nogueira, L.P., Colaço, M.V., Mota, C.L., Pickler, A., Braz, D., Salata, C., Ferreira-Machado, S., de Almeida, C.E. and 755contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Facility, at the beamline TwinMic, in Trieste, Italy.

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Section: Discussionmentioning

confidence: 99%

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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“…[ 11 ] It has now been suggested that hypomagnesemia decreases the expression of L-type Ca 2+ channels that reduces insulin secretion indirectly. [ 47 ] Another plausible role of Mg 2+ is controlling L-type Ca 2+ channel opening via blocking Ca 2+ uptake into adipocytes. [ 5 ]…”

Section: L-type Ca 2+ Channelmentioning

confidence: 99%

The therapeutic effects of magnesium in insulin secretion and insulin resistance

2022

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“…A nivel cardiaco, el Mg 2+ tiene efectos sobre la conductividad y contractilidad, ya que regula la actividad de varios canales iónicos y la movilidad del Ca 2+ dentro del miocito cardiaco. En cuanto a las corrientes iónicas de los miocitos, el Mg inhibe los canales voltaje dependientes tipo L de Ca 2+ , por lo que previene la toxicidad dada por la sobrecarga de Ca 2+ y regula la fase 2 del potencial de acción del cardiomiocito [65,66,67].…”

Section: Implicaciones Clínicasunclassified

“…También el porte de Ca 2+ como Estudios clínicos demuestran una tendencia a que los pacientes con calambres tratados con disminuyen la frecuencia con que estos aparecen; sin embargo, estos datos fueron significativos solamente para pacientes embarazadas con calambres en miembro inferior tiene efectos sobre la lidad, ya que regula la actividad de varios canales iónicos y la movilidad dentro del miocito cardiaco. En cuanto a las corrientes iónicas de los miocitos, el Mg 2+ inhibe los canales voltaje dependientes tipo L de cidad dada por la y regula la fase 2 del potencial de acción del cardiomiocito [65,66,67].…”

Section: Implicaciones Clínicasunclassified

“…Estudios en músculo cardiaco de mamíferos han demostrado que altas concentraciones de Mg 2+ intracelular provocan disminución de la función Clínicamente, se ha demostrado que ante eventos isquémicos (infarto agudo y postcirugía cardiaca) la suplementación con Mg 2+ reduce la aparición de arritmias supraventriculares [66,70,71]. Sin embargo, los estudios no han demostrado tener una significancia estadística que apoye la recomendación clínica de suplementación de Mg 2+ s en contexto postoperatorio [72].…”

Section: Conclusionesunclassified

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Homeostasis del magnesio: Implicaciones fisiológicas y patológicas.

Rojas¹,

Arrieta-Leandro²,

Wegley³

et al. 2018

Rev Med UCR

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La deficiencia moderada o severa de magnesio (Mg2+) lleva a anormalidades bioquímicas y manifestaciones clínicas relacionadas con el músculo esquelético, músculo cardiaco y patologías renales. El Mg2+participa en múltiples procesos homeostáticos como el metabolismo energético, la duplicación y transcripción de material genético, el transporte de sustancias a través de la membrana citoplasmática y reacciones enzimáticas. La regulación de las concentraciones de Mg2+ en el líquido extracelular y en el líquido intracelular depende de factores hormonales (insulina y hormona paratiroidea); intestinales (absorción paracelular) y renales (reabsorción en el asa de Henle); además de los depósitos de reserva en hueso y músculo. A pesar de que el Mg2+ está presente en varios alimentos, estudios en subpoblaciones costarricenses evidencian dietas con inadecuado aporte de Mg2+. La hipomagnesemia provocada por dietas insuficientes de Mg2+ contribuye a desarrollar procesos patológicos tales como calambres, arritmias e hipertensión arterial. La presente revisión pretende describir las bases de la función del Mg2+ en la fisiología humana; los mecanismos de absorción, regulación, excreción y su homeostasis, así como la importancia clínica de los efectos de su baja ingesta, la cual se vuelve cada vez más prevalente.

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Hypomagnesemic down-regulation of L-type Ca2+ channel in cardiomyocyte as an arrhythmogenic substrate in rats

Cited by 5 publications

References 24 publications

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

The therapeutic effects of magnesium in insulin secretion and insulin resistance

Homeostasis del magnesio: Implicaciones fisiológicas y patológicas.

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