The therapeutic effects of magnesium in insulin secretion and insulin resistance

Dastgerdi, Azadehalsadat Hosseini; Rad, Mahtab Ghanbari; Soltani, Nepton

doi:10.4103/abr.abr_366_21

Cited by 6 publications

(2 citation statements)

References 89 publications

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“…24 Mg supplementation could increase insulin secretion and improve the ability of beta-cells to compensate for changes in insulin sensitivity in healthy individuals. 25 Mg intake has also been strongly and negatively correlated with metabolic syndromes. Hypomagnesemia has been independently associated with the development of IGT.…”

Section: Discussionmentioning

confidence: 99%

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance

Zhao,

Zhou,

Shang

et al. 2024

Diabetes and Vascular Disease Research

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Purpose To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR). Methods 120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were measured at baseline and after 3 months intervention. Results Comparison among groups showed that fasting plasma glucose (FPG), 2 h post glucose (2hPPG), fasting insulin (FINS) and homeostatic model assessment for insulin resistance (HOMA-IR) in Cr + Mg group were significantly decreased compared with the other three groups ( p < .05), and high density lipoprotein (HDL-c) levels were higher. 8-iso prostaglandin F2 alpha (8-iso-PGF2a) decreased in Cr, Mg, and Cr + Mg groups compared with placebo ( p < .05), and 8-iso-PGF2a decreased in Cr + Mg groups compared with Cr group and Mg groups ( p > .05). Intra-group comparison showed that the levels of FPG, 2hPPG and FINS in Cr + Mg group were significantly decreased after intervention ( p < .05), and FINS in Mg group was significantly decreased ( p < .01). The levels of HDL-c and triacylglycerol (TG) in Cr + Mg group were significantly improved ( p < .05). The level of HDL-c in Mg group was significantly improved compared with baseline ( p < .05). Compared with baseline, high-sensitivity C-reactive protein (hsCRP) levels in Cr + Mg group and Mg group were significantly decreased ( p < .05). Conclusions The co-supplementation of Cr and Mg improves glycemic and lipid levels and reduces the inflammatory response and oxidative stress profiles of individuals with impaired glucose tolerance and insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance

Zhao,

Zhou,

Shang

et al. 2024

Diabetes and Vascular Disease Research

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show abstract

“…Therefore, high daily magnesium consumption can reduce the risk of developing type 2 diabetes [22]. A meta-analysis of numerous studies showed that the oral consumption of magnesium supplements and the incorporation of the right foods into one's diet can significantly enhance insulin sensitivity and metabolic control in people with type 2 diabetes [23]. The strong correlation between hypomagnesemia and diabetes is further elaborated upon in Figure 1.…”

Section: Hypomagnesemia and Diabetesmentioning

confidence: 96%

Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

Pethő,

Fülöp,

Orosz

et al. 2024

Clinics and Practice

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The importance of maintaining proper magnesium intake and total body magnesium content in preserving human health remains underappreciated among medical professionals and laymen. This review aimed to show the importance of hypomagnesemia as a modifiable risk factor for developing disease processes. We searched the PubMed database and Google Scholar using the keywords ‘magnesium’, ‘diabetes’, ‘cardiovascular disease’, ‘respiratory disease’, ‘immune system’, ‘inflammation’, ‘autoimmune disease’, ‘neurology’, ‘psychiatry’, ‘cognitive function’, ‘cancer’, and ‘vascular calcification’. In multiple contexts of the search terms, all reviews, animal experiments, and human observational data indicated that magnesium deficiency can lead to or contribute to developing many disease states. The conclusions of several in-depth reviews support our working hypothesis that magnesium and its supplementation are often undervalued and underutilized. Although much research has confirmed the importance of proper magnesium supply and tissue levels, simple and inexpensive magnesium supplementation has not yet been sufficiently recognized or promoted.

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Metabolomic characteristics of cord blood from neonates with hyperkalemia after antenatal exposure to ritodrine and magnesium sulfate

Inoue,

Sekiguchi,

Tsushita

et al. 2024

Preprint

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In the management of pregnancy, ritodrine has been used to prevent preterm birth, and magnesium sulfate (MgSO4) has been used to prevent preterm labor and preeclampsia. Neonates born to mothers receiving these medications occasionally show an increase in serum potassium concentration. Recently, an elevated risk of neonatal hyperkalemia has been reported, particularly when ritodrine and MgSO4 are co-administered; however, the underlying mechanisms remain unclear. We investigated the association between potassium levels and metabolites in the serum of umbilical cord blood of infants with antenatal exposure to antenatal ritodrine and MgSO4 using a metabolomic analysis. Our findings revealed a significant elevation in serum potassium concentration associated with metabolomic findings of activation of glycolysis and the derived metabolic routes in preterm neonates exposed to both ritodrine and MgSO4. Our data indicate that the concurrent administration of ritodrine and MgSO4 caused distinctive metabolic alterations, potentially leading to an additional increase in the intracellular potassium concentration in the fetus. Consequently, this mechanism may imply an elevation in serum potassium concentration postnatally through the redistribution of potassium.

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The therapeutic effects of magnesium in insulin secretion and insulin resistance

Cited by 6 publications

References 89 publications

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance

Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

Metabolomic characteristics of cord blood from neonates with hyperkalemia after antenatal exposure to ritodrine and magnesium sulfate

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