Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Abstract

Abstract. In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. leaves (AC) in mice and then determined its activities in related enzymes. The results showed that AC (0.40 g / kg) significantly inhibited the increase in serum triglycerides by 40% in fructose-fed mice. In mice induced by alloxan and high-fat diets, serum total cholesterol remained at a high level (180 -220 mg / dl) within 7 days of removing high-fat diets but reached normal level (120 -140 mg / dl) after AC (0.40 g / kg per day) treatment. Also, AC (0.40 and 0.80 g / kg) significantly inhibited serum lipids from the increase in Triton WR-1339-induced hyperlipidemic mice. AC (0.01 -100 µg / ml) selectively activated lipoprotein lipase (LPL) activity by 200% -400% and significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity by 20% -49% in vitro. Furthermore, 2 months of fenofibrate (0.20 g / kg) administration particularly increased mice liver weights (0.0760 ± 0.0110 g / g) while AC (0.40 g / kg) had no effect (0.0403 ± 0.0047). Taken together, these results suggest that AC will be a new potential natural product for the treatment of hyperlipidemia that exerts its actions through mechanisms of inhibiting HMGCoA reductase and activating LPL activities. Its action mechanisms differentiate from those with fibrates but may be partly similar to those with statins. It is hopeful that AC may serve as the adjuvant for fibrates.

Utilization of Pineapple Waste: A Review

“…The extract also inhibited the development of insulin resistance in HepG2 cells. The ethanolic extract of pineapple leaves with high phenolics has significantly inhibited the increase in serum triglycerides by 40% in fructose-fed mice (Xie et al, 2007). The extract selectively activated lipoprotein lipase coenzyme A reductase activity by 20-49% in vitro thereby indicating the hypolipidemic effect of the extract.…”

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

“…Neste contexto, crescem em importância estudos para o desenvolvimento de novas alternativas terapêuticas eficazes e acessíveis às populações de baixa renda, sendo as plantas medicinais aliadas extremamente úteis, pois fornecem extratos e compostos químicos isolados, cujas capacidades anorexígena e hipolipidêmica vêm sendo demonstradas em inúmeros trabalhos científicos de várias partes do mundo (Kidwai & Upreti, 1993;Jorge et al, 1998;Heerden et al, 2007;Lei et al, 2007;Xie et al, 2007;Bahramikia & Yazdanparast, 2008;Cardozo et al, 2008;Harnafi et al, 2008;Murray et al, 2008;Ming et al, 2009).…”

Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

“…Both HE and quercetrin lowered serum-TG levels, similar to the simvastatin group. A previous study using other plants suggested that these effects are attributed to the restoration of TG catabolism by stimulating lipolytic pathways involving plasma lipoprotein lipase (LPL) (Xie et al, 2007). Moreover, quercetin can reduce the activities and mRNA levels of several enzymes involved in the synthesis of fatty acids (Odbayar et al, 2006).…”