Hypolipidemic, antioxidant and anti—atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet—induced hypercholesterolemic rats

Ntchapda, Fidèle; Kakesse, Maguirgue; Hamadjida, Adjia; Etet, Paul Faustin Seke; Dimo, Théophile

doi:10.1016/s1995-7645(14)60344-8

Cited by 15 publications

(6 citation statements)

References 32 publications

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“…These results showed a reduction in atherosclerosis and lipid profiling. This trial concluded that this plant can be used as a medicinal agent to treat atherosclerosis (Ntchapda et al, 2015).…”

Section: Zanthoxylum Heitziimentioning

confidence: 95%

Potential role of medicinal plants for anti-atherosclerosis activity

Qadir

Manzoor

Akash

2018

Bangladesh J Pharmacol

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Atherosclerosis may lead to the death of a number of people. In case of atherosclerosis, stiffness of arteries of the heart is caused by the excess deposition of lipids in the coronary arteries. The mentioned condition produces atherosclerotic plaques. When these plaques are burst then clots of blood are formed that cause coronary issues. To overcome this severe disease, extracts of many medicinal plants or spices like garlic, ginger and onion, and many others that are mentioned in this review are used to treat atherosclerosis.

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Section: Zanthoxylum Heitziimentioning

confidence: 95%

Potential role of medicinal plants for anti-atherosclerosis activity

Qadir

Manzoor

Akash

2018

Bangladesh J Pharmacol

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“…Histological studies of cross-sections of the aorta were made at 20× magnification using camera lucida drawings. 29 The histological slides were graded using a semi-quantitative scoring system and were assigned severity grades according to the percentage of foam cells observed in each group; that is, 0 ≤ 1%, 1 < 25%, 2 = 25–50%, 3 = 50–75% and 4 > 75%.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

et al. 2023

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Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of Caralluma edulis (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was induced in Wistar albino rats with HFD (1% cholesterol + 0.5% cholic acid) for 28 days. Treatment groups were administered with different doses of CE.Cr (100, 300 and 500 mg/Kg, p.o.) and the standard group received atorvastatin. At the end of study, sera were analyzed for biochemical markers and the aorta was dissected for microscopic examination. Antioxidant potential was evaluated and high-performance liquid chromatography (HPLC) analysis was performed. The hypotensive potential of CE.Cr was evaluated through an invasive technique. HPLC analysis of CE.Cr showed the presence of chlorogenic acid, caffeic acid, apigenin and naringenin. Histological examination of the aorta section showed anti-atherosclerotic effects which were also evident from decrease in serum total cholesterol, triglycerides and low-density lipoproteins levels. CE.Cr decreased mean arterial blood pressure and evoked significant hypotensive effects. The crude extract of C. edulis showed anti-obesity, antihypertensive, anti-atherosclerotic and antioxidant potential.

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“…Berdasarkan data Tabel 4 kelompok kontrol negatif terjadi penurunan sebesar 29,94% hal tersebut menunjukkan pakan standar tidak menyebabkan kenaikan kadar kolesterol total, persentase penurunan kadar kolesterol total terbesar 31,29% terjadi pada kelompok rebusan daun mangga dosis 200mg/kgBB. Hal tersebut diyakini karena adanya flavonoid, saponin dan tanin (13). Flavonoid mampu menginhibisi enzim HMG-CoA reductase, sehingga mampu menurunkan kolesterol darah.…”

Section: Penurunan Kadar Kolesterol Totalunclassified

Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi)

Suprijono¹,

Susilawati²,

Aolina³

2022

JFI

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Dyslipidemia is characterized by changes in lipid levels in plasma, a common indicator that is prone to the risk of cardiovascular disease. Plants that are suspected to have antidislipidemia activity, one of which is mango leaves. This study aimed to determine the effective dose in a decoction of mango manalagi leaves (Mangifera indica L. var. Manalagi) in decreasing levels of total cholesterol, triglycerides, LDL, and increasing HDL levels in high-fat feed-induced rats and propylthiouracil for 28 days. This research method was carried out preventively using 30 Wistar strain male rats which were grouped into 6 groups, namely negative control, positive control, comparison control (simvastatin 1.8mg/Kg BW), and a decoction test of manalagi mango leaves at a dose of 200, 400, 800 mg/kg BW. The parameters of the observed lipid profile are determined enzymatically using the micro lab. The results of the study on total cholesterol levels, showed the largest decreasing in the 200mg/kg BW dose group by 31.29%, in triglyceride levels the largest decreasing was found in the 400mg/kg BW dose group by 40.59%, in LDL levels the largest decreasing was found in the 200 mg/kg BW dose group by 48.03%, and in HDL levels there was the largest increasing in dose 800mg /kg BW of 97.40%. This study concludes that manalagi mango leaf decoction can be an antidyslipidemia in decreasing total cholesterol, triglyceride, and LDL levels as well as increasing HDL levels, with an effective dose of 200mg/ kg BW.

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Hypolipidemic, antioxidant and anti—atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet—induced hypercholesterolemic rats

Abstract: These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties, at least partly mediated by antioxidant and hypolipidemic effects.

Cited by 15 publications

References 32 publications

Potential role of medicinal plants for anti-atherosclerosis activity

Potential role of medicinal plants for anti-atherosclerosis activity

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi)

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