Hypolipidemic and antioxidant effects of the Methanolic stem bark extract of Anacardium occidentale Linn. In triton-X 100 induced hyperlipidemic rats

Anyaegbu, Ogochukwu C.; Ajayi, Abayomi Mayowa; Adedapo, Aduragbenro Deborah

doi:10.1007/s13596-017-0262-1

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Administration of ethanolic stem bark extract of A. occidentale lowers total cholesterol and triglyceride while HDL-cholesterol level was increased in diabetic rats. This result is consistent with previous studies that have demonstrated hypolipidemic effect for A. occidentale (Olatunjji et al, 2005;Anyaegbu et al, 2017). Hyperglycemia-induced oxidative stress and its resultant cellular effects are well established in several studies (Fiorentino et al, 2013).…”

Section: Discussionsupporting

confidence: 93%

“…This finding suggests that administration of ethanol stem bark extract of A. occidentale prevents lipid peroxidation in STZ-induced diabetic rats. This is similar to earlier reports where methanol stem bark extract of A. occidentale reduced MDA level in triton X-100 induced hyperlipidemic and fructose-induced diabetic rats (Olatunji et al, 2005;Anyaegbu et al, 2017). Antioxidant enzymes such as SOD, CAT and GST produced by mammalian cells as defense against ROS generation are closely related to lipid peroxidation.…”

Section: Discussionsupporting

confidence: 92%

“…This ameliorative effect, especially with the 400 mg/kg body weight extract is also observed to be similar to what was obtained with the antidiabetic drug, metformin. The increase in GSH and improvement in antioxidant enzymes activities under A. occidentale supplementation had been reported previously in the liver and kidney of Triton X-100 induced hyperlipidemic rats (Anyaegbu et al, 2017). These results clearly showed that ethanolic extract of A. occidentale possess potent antioxidant activity.…”

Section: Discussionsupporting

confidence: 83%

“…These results clearly showed that ethanolic extract of A. occidentale possess potent antioxidant activity. Evidence has shown that A. occidentale stem bark extract is rich in total phenolic and total flavonoid contents (Anyaegbu et al, 2017), and there are reports of presence of several phenolic compounds in the stem bark and leaves extract of A. occidentale (Encarnacao et al, 2014;. Therefore, the antioxidant effects shown by A. occidentale stem bark extract could be ascribed to the ability of its individual bioactive components to scavenge and/or quench free radicals generated due to diabetic induction, and boost the synthesis of GSH and other key enzymes.…”

Section: Discussionmentioning

confidence: 99%

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Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale in Streptozotocin-Induced Diabetic Rats

Bamisaye¹,

Ibrahim²,

Sulyman³

et al. 2022

NJPS

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Diabetes mellitus is one of the most widespread diseases affecting the world’s population causing substantial morbidity, mortality and long-term complications. This study was designed to investigate possible hypoglycemic, hypolipidemic and antioxidant effect of ethanolic stem bark extract of Anacardium occidentale in streptozotocin (STZ)-induced diabetic rats. Twenty-eight STZ (60 mg/kg body weight)-induced diabetic, male albino rats were randomly distributed into Groups II-V (7 rats each) and orally administered with water, metformin (14.2 mg/kg), 200 mg/kg Anacardium occidentale extract and 400 mg/kg Anacardium occidentale extract respectively daily for 15 days. Group I rats were untreated with STZ and serves as control all under the same sham handling. Blood samples were taken for measurement of fasting blood glucose (FBG) and lipid profile. Liver and kidney tissue samples were taken for determination of glycemic indices (glucose and glycogen), as well as redox status markers such as malondialdehyde (MDA), total glutathione (GSH), activities of superoxide dismutase (SOD) and glutathione-s-transferase (GST). Results showed that treatment with 200 and 400 mg/kg Anacardium occidentale stem bark extract reversed hyperglycemia and hyperlipidemia induced by STZ similar to what was observed with the standard drug, metformin. Similarly, both extract concentration produced a significant reduction in MDA while the activity of SOD and GST, as well as concentration of GSH were elevated. This study suggested that ethanolic stem bark extract of Anacardium occidentale at 200 and 400 mg/kg can ameliorate diabetes and its associated complications via its hypoglycemic, hypolipidemic, antioxidant and free radical scavenging properties

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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