Hypolipidemic and antiatherosclerotic properties of terpenoid coumarins

Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet

“…In fact, many chemical constituents have already been characterized in Ajuga iva such as clerodane diterpenoids called Ivain I-IV (Camps et al, 1982), and 14,15-dihydroajugapitin (Bondi et al, 2000), ecdysteroids such as makisterone A, 20 hydroxyecdysone, cyasterone, and their derivatives (Wessner et al, 1992), iridoids such as harpagide, 8-O-acetylharpagide and two flavonoids such as naringin and apigenin-7-O-neohesperidoside (Ghedira et al, 1991). Since phytoecdysteroids and flavonoids have been reported to present antioxydant and hypocholesterolemic activity (Syrov et al, 1983;Wagner and Lacaille-Dubois, 1995), it may be suggested that the hypolipidemic and antioxidant activity of Ajuga iva might be correlated to these compounds. Purification and characterisation of the compounds from the active extract are in progress.…”

Chemistry and Biological Activity of Natural and Synthetic Prenyloxycoumarins †

“…Diversinin (77), diversoside (90) and diversin (99) were isolated from Ferula diversivittava [142]. In experiments carried out on rats these terpenoid coumarins, especially 99, considerably decreased cholesterol and triglyceride blood levels [155]. Auraptenal (82), first isolated by Bohlmann from Capnophyllum peregrinum [212], was shown to possess spasmolytic [154] and antimicrobial activities [146].…”

“…[60] (R)-7-(6-hydroxy-3,7-dimethylocta-2,7-dienyloxy)-coumarin (78) OH Citrus hassaku, [146] Phebalium spp. [60] 7-(7-hydroxy-3,7-dimethylocta-2,5-dienyloxy)-coumarin (79) HO Clausena excavata, [137] Esenbeckia grandiflora, [138] Phebalium spp., [60] Phellodendron chinense, [147] Zanthoxylum schinifolium [141] Epoxyauraptene (80) O Aegle marmelos, [148] Aster yunnanensis, [149] Citrus spp., [150][151][152] Zanthoxylum schinifolium [140] 7-(3,7-dimethyl-6-oxooct-2-enyloxy)-coumarin (81) O Baccharis darwinii, 153] Citrus hassaku [154] Auraptenal (82) O Capnophyllum peregrinum, [155] Citrus hassaku [154] 7-(5,6-dihydroxy-3,7-dimethylocta-2,7-dienyloxy)-coumarin (83) OH OH Zanthoxylum schinifolium [141] Excavatin A (84) HO OH Clausena excavata [137] Marmin (85) OH HO Aegle marmelos, [156] Aster praealtus. [157] Aurantii fructus immaturus, [158] Citrus grandis, [159] Citrus hassaku, [154] Eremocitrus glauca, [160] Ferula malacophyla , [161] Geijera parviflora, [162] Pituranthos triradiatus, [163] Xue-Fu-Zhu-YuTang [164] Marmin 7-(methylether) (86)…”

The Karlson Lecture. Phytoecdysteroids: What use are they?

“…Hypocholesterolaemic agents. Ecdysteroids have been reported to reduce cholesterol levels by reducing biosynthesis, enhancing its catabolism (Uchiyama and Yoshida, 1974), and promoting conversion into bile acids (Syrov et al, 1986b), producing hypocholesterolaemic (Lupien et al, 1969) and antiatherosclerotic (Syrov et al, 1983) effects.…”