Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats

Pattanayak, Sandhya; Nayak, Siva Shankar; Panda, Durgaprasad; Shende, Vikas

doi:10.3329/bjp.v4i2.2996

Cited by 13 publications

(13 citation statements)

References 8 publications

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“…Ethnopharmacological and ethno botanical surveys indicate that more than 1200 plants are used worldwide in herbal medicine to treat diabetes (Ziyyat et al, 1997;El-Hilaly et al, 2003;Tahraoui et al, 2007 (Prajapati et al, 2008;Ravi et al, 2009;Pattanayak et al, 2009;Tatiya et al, 2013;Bandara et al, 2009;Saha et al, 2009;Bhowmik et al, 2009;Sen et al, 2013;Khanam et al, 2009;Alamgeer et al, 2013;Bhavsar and Talele, 2013;Kulandaivel et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits

Irshad

Akhtar

Kamal

et al. 2013

Bangladesh J Pharmacol

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The current study was designed to evaluate the hypolipidemic and renoprotective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits. Article Info

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Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits

Irshad

Akhtar

Kamal

et al. 2013

Bangladesh J Pharmacol

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“…Therefore, the search for new antidiabetic agents with more effectiveness and lesser adverse effects has continued. More than 400 plant species having antihyperglycemic effect have been mentioned in the literature (Pattanayak et al, 2009). Some of them are being used in traditional systems of medicine from hundreds of years in many countries of the world (Hussain, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

Yusufoğlu¹,

Soliman²,

Abdel-Rahman³

et al. 2015

International J. of Pharmacology

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“…Therefore, discovery and development of novel drugs from herbs will not be out of place. Herbal drugs or their extracts such as Cajanus scarabaeoides (Pattanayak et al, 2009), Lagerstroemia speciosa (Saha et al, 2009) and Teucrium stocksianum (Alamgeer et al, 2013), are prescribed widely even when their bioactive compounds are unknown (Gupta et al, 2005). Therefore, studies with plant extracts are useful in order to determine their efficacy, mechanism of action and bioactive agent(s) that are responsible for such pharmacological effect and safety.…”

Section: Introductionmentioning

confidence: 99%

Effects of aqueous extract of Fadogia agrestis stem in alloxan-induced diabetic rats

Yakubu

Ogunro

2014

Bangladesh J Pharmacol

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Aqueous extract of Fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight was investigated for antidiabetic activity in alloxan-induced diabetic rats. The results revealed that the administration of alloxan significantly increased (p<0.05) the levels of blood and hepatic glucose, serum urea, creatinine, albumin, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, atherogenic index and very low-density lipoprotein cholesterol whereas the organ/body weight ratio, activity of hexokinase, levels of highdensity lipoprotein cholesterol, packed cell volume and hemoglobin reduced significantly. In contrast, all the doses of the extract significantly reversed the levels of these biomolecules/biochemical parameters. These reversals, however, did not compare well with their respective control values by the end of exposure period. Overall, the aqueous extract of F. agrestis stem showed promise as an antidiabetic agent. Article Info

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Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats

Cited by 13 publications

References 8 publications

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

Effects of aqueous extract of <i>Fadogia agrestis</i> stem in alloxan-induced diabetic rats

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