Effects of aqueous extract of <i>Fadogia agrestis</i> stem in alloxan-induced diabetic rats

Abstract

Aqueous extract of Fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight was investigated for antidiabetic activity in alloxan-induced diabetic rats. The results revealed that the administration of alloxan significantly increased (p<0.05) the levels of blood and hepatic glucose, serum urea, creatinine, albumin, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, atherogenic index and very low-density lipoprotein cholesterol whereas the organ/body weight ratio, activity of hexokinase, levels of highdensity lipoprotein cholesterol, packed cell volume and hemoglobin reduced significantly. In contrast, all the doses of the extract significantly reversed the levels of these biomolecules/biochemical parameters. These reversals, however, did not compare well with their respective control values by the end of exposure period. Overall, the aqueous extract of F. agrestis stem showed promise as an antidiabetic agent. Article Info

Chromatographic fractions from Chrysophyllum albidum stem bark boost antioxidant enzyme activity and ameliorate some markers of diabetes complications

“…Blood samples were drawled from the sharply cut tail vein of the rats and placed on the test strip that had been inserted into the glucometer. 15 Animals with blood glucose level equal to or more than 250 mg/dL were considered diabetic and used for the experiment. 16 …”

“…Fasting blood glucose was determined as described by Yakubu and Ogunro, 15 Serum insulin as described in the ELISA kits (Elabscience Biotechnology Co., Ltd), superoxide dismutase as described by Misra and Fridovich, 17 Catalase as described by Beers and Sizer, 18 malondialdehyde levels as described by Varshney and Kale, 19 glycosylated haemoglobin as described by Trivelli et al. , 20 C-reactive protein as described by Burtis et al.…”

Aphrodisiac agents used in traditional medicine and their mechanism of action - A Review

“…d. Increase in testicular, serum cholesterol and testosterone levels have been shown to be linked to the aphrodisiac activity of medicinal plants. This is sequel to cholesterol being a precursor for the production of several physiologically important steroids which include sex hormone, bile acid and vitamin D. Following the increase in cholesterol, testosterone concentration may increase via steroidogenesis which should normally reflect in a corresponding increase in libido [36,53] . [54] Fig 6 .0: Mucuna pruriens Mucuna pruriens (L) DC is a plant used as an aphrodisiac; it belongs to the family of Leguminosae which is the second largest flowering plant Figure 6.0.…”

“…The methanol extract of Fadogia agretis stem increased the blood testosterone concentration and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviours. It may be used to modify impaired sexual function in animals, especially those arising from hypotesteromia [53,68,69,132] . Benzophenone glycoside has been isolated from the aqueous fraction of the root as illustrated in Figure 13.0 [71] .…”

Effects of methanol leaf extracts of <i>Loranthus micranthus</i> Linn from three host plants on some biochemical indices of diabetic rats

“…Blood samples were collected and put into plain and also heparinized sample tubes for serum and hematological analysis respectively [5,13]. The procedures for the analysis have been previously described [13].…”