Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

Yusufoğlu, Hasan Soliman; Soliman, Gamal A.; Abdel-Rahman, Rehab F.; Abdel‐Kader, Maged S.; Genaie, Majid; Bedir, Erdal; Erel, Ş Baykan; Öztürk, Bintuğ

doi:10.3923/ijp.2015.738.748

Cited by 12 publications

(13 citation statements)

References 27 publications

(25 reference statements)

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“…Several studies in diabetes, demonstrated free radicals are increased by some reactions derived from the development of the disease and defense against radicals decreases [12,13]. In addition, the activity of antioxidant enzymes in pancreatic homogenates from diabetic animals has been shown to decrease with oxidative stress [17,42], however, further studies are needed to prove this claim for F. caspica and F. halophila extracts.…”

Section: Discussionmentioning

confidence: 99%

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Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

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The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants' extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

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Section: Discussionmentioning

confidence: 99%

“…Some species are used as aphrodisiac, antidiabetic and anticholesterolemic agent in Turkey [9]. Besides that, antispasmodic [10,11], antidiabetic and antihyperlipidemic [12,13], cytotoxic [14,15] and antimicrobial [16] activities of different Ferula species were reported previously. The aerial parts of F. caspica M. Bieb.…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

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“…2,12 In addition, the extracts have been reported to have antimicrobial, anthelmintic, anticonvulsant, antispasmodic, antihyperglycemic, antihyperlipidemic, and antioxidant activities. [13][14][15][16][17][18]…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Sesquiterpenoids Isolated from Endemic <i>Ferula tenuissima</i> Hub.-Mor & Peşmen

Aydoğan

Baykan

Bütüner

2019

tjps

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Amaç: Endemik Ferula tenuissima köklerinin fitokimyasal yönden incelenmesi ve elde edilen saf bileşiklerin PC-3 üzerinde sitotoksik etkilerinin belirlenmesidir. Gereç ve Yöntemler: F. tenuissima 'nın açık havada kurutulmuş ve toz haline getirilmiş kökleri (1 kg, 24 saat boyunca 30°C'de sonikasyonda n-hexane, kloroform (CHCl 3) ve metanol (MeOH) (3×2 L, her biri) ile sırasıyla ekstre edilmiştir. Ekstraktlar daha sonra süzülmüştür. Sıvı ekstreler, vakum altında kuruluğa kadar uçurulmuştur. Kromatografik yöntemler ile bileşikler elde edilmiş ve bileşiklerin yapıları spektral yöntemler ile belirlinmiştir (1D-, 2D NMR ve LC-MS). Bileşiklerin PC-3 üzerindeki sitotoksik aktiviteleri WST yöntemi ile test edilmiştir. Bulgular: Endemik F. tenuissima'nın kurutulmuş köklerinin fitokimyasal incelemesi yapılmış ve üç seskiterpen esteri izole edilmiştir. Teferidin, ferutinin ve elaeochytrin-A daukan tip seskiterpen esterleri olarak belirlenmiştir. Biyoaktivite çalışmasında, ferutinin en yüksek sitotoksik aktiviteyi IC 50 : 19.7 µM ile göstermiştir. Sonuç: F. tenuissima köklerinin ana bileşiklerinin daukan seskiterpenler ve ferutininin PC-3 hücreleri üzerinde potansiyel bir etkiye sahip olduğunu göstermektedir. Anahtar kelimeler: Ferula tenuissima, daukan seskiterpen ester, sitotoksite, prostat kanseri Objectives: This was a phytochemical study of endemic Ferula tenuissima roots and determined the cytotoxic activity of pure compounds on PC-3. Materials and Methods: Air-dried and powdered roots of F. tenuissima (1 kg) were extracted consecutively with n-hexane, chloroform (CHCl 3), and methanol (MeOH) (3×2 L, each) by sonication at 30°C for 24 h. The extracts were then filtered. The solvents were separately evaporated under reduced pressure to dryness. The compounds were isolated by chromatographic methods and their structures were determined by spectral methods (1D and 2D NMR and LC-MS). The compounds were tested for their cytotoxic activities versus the PC-3 cell line by WST assay. Results: A phytochemical investigation of the dried roots of endemic F. tenuissima was performed and three sesquiterpene esters were isolated. The daucane-type sesquiterpenes teferidin, ferutinin, and elaeochytrin-A were identified. In the bioactivity study, ferutinin exhibited the highest cytotoxic activity, with an IC 50 value of 19.7 µM. Conclusion: The results indicate that the main compounds of F. tenuissima roots are daucane sesquiterpenes and ferutinin has a potential effect on PC-3 cells.

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“…2,12 In addition, the extracts have been reported to have antimicrobial, antihelminthic, anticonvulsant, antispasmodic, antihyperglicemic, antihyperlipidemic and antioxidant activities. [13][14][15][16][17][18]…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Daucane Sesquiterpene Esters Isolated From Endemic Ferula tenuissima HUB. MOR& PEŞMEN

Aydoğan¹,

Baykan²,

Bütüner³

2018

tjps

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Objectives: Phytochemical study of endemic Ferula tenuissima roots and determination of the cytotoxic activity of pure compounds on PC-3. Materials and Methods: Air-dried and powdered roots of F. tenuissima (1 kg) were extracted respectively with n-hexane, chloroform (CHCl3) and methanol (MeOH) (3x2 L, each) by sonication at 30 ºC, for 24h. The extracts were then filtered. The solvents separately evaporated under reduced pressure to dryness. Compounds were isolated by chromatographic methodes and structures of compounds were determined by spectral methodes (1D-, 2D NMR and LC-MS). Compounds were tested for their cytotoxic activities versu PC-3 cell line by WST assay. Results: Phytochemical investigation of dried roots of endemic F. tenuissima performed and three sesquiterpene esters were isolated. As teferidin, ferutinin and elaocyhtrin-A; daucane-type sesquiterpenes were identified. In the bioactivity study, Ferutinin exhibitited the highest cytotoxic activity with 19.7 µM IC50 value. Conclusion: The results indicate that the main compounds of Ferula tenuissima roots are daucane sesquiterpenes and ferrutinin has potential effect on PC-3 cells.

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Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

Cited by 12 publications

References 27 publications

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Cytotoxic Activity of Sesquiterpenoids Isolated from Endemic <i>Ferula tenuissima</i> Hub.-Mor & Peşmen

Cytotoxic Activity of Daucane Sesquiterpene Esters Isolated From Endemic Ferula tenuissima HUB. MOR& PEŞMEN

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