Hypoglycemic herbs and their polyherbal formulations: a comprehensive review

Katiyar, Deepti; Singh, Vijender; Gilani, Sadaf Jamal; Goel, Richa; Grover, Parul; Vats, Amita

doi:10.1007/s00044-014-1080-3

Cited by 16 publications

(5 citation statements)

References 23 publications

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“…The powdered root extract along with different solvent systems was allowed to stand for 48 hours. After filtration, chemical tests allow the qualitative analysis of the extract [ 18 , 28 ]. The presence of several chemical classes of compounds, such as alkaloids, glycosides, terpenoids, flavonoids, saponins, carbohydrates, lipids, volatile oils, steroids, phenols, tannins, gums, and mucilage, was determined.…”

Section: Methodsmentioning

confidence: 99%

Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains

Kandasamy¹,

Ghai²,

Varshney³

et al. 2022

International Journal of Microbiology

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Antibiotic resistance represents one of the biggest challenges, and there is an urgent need for plant-based antimicrobial agents that enable managing this crisis effectively. In this work, we aimed to investigate the antibacterial activity of Astragalus candolleanus (A. candolleanus) hydromethanolic root extract against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Kocuria rhizophila) strains by the cup-plate method. The root was powdered and extracted with 70% methanol by cold maceration for 5 days. Preliminary phytochemical screening was performed with different solvents in the order of increasing polarity. Pure compounds were isolated by column chromatography and were characterized through liquid chromatography-mass spectrometry. Targeted predictions of the isolated compounds were also studied using Swiss Target prediction software and prediction of activity spectra for substances. The extract showed a broad zone of inhibition against pathogenic bacteria. Four pure compounds were isolated, of which a novel terpenoid compound has been identified as stemmadenine along with scillirosidin, cephalotaxine, and myxoxanthophyll. The structures of the isolated phytoconstituents were elucidated by spectral analysis. The four pure components isolated from the roots of A. candolleanus are suggested to be effective against tested pathogens. Overall results of drug design suggest that myxoxanthophyll is a promising bioactive compound endowed with antibacterial activity.

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Section: Methodsmentioning

confidence: 99%

Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains

Kandasamy¹,

Ghai²,

Varshney³

et al. 2022

International Journal of Microbiology

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“…Therapeutic actions of medicinal plants depend on the different phytochemicals classes interactions. 93 Several studies have reported the antidiabetic activities of numerous isolated plant compounds. 94 Plants such as soybean, bitter melon, garlic, cocoa, walnut, aloe, caper, nettle, fenugreek, melon, coffee, sage, yerba mate, black and green tea have medicinal properties and are commonly utilized in diabetes and its associated comorbidities treatment.…”

Section: Treatment Of Diabetesmentioning

confidence: 99%

A Compendium of Perspectives on Diabetes: A Challenge for Sustainable Health in the Modern Era

Verma¹,

Goyal²,

Bhatt³

et al. 2021

DMSO

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Diabetes is a chronic illness. Hyperglycemia is the characteristic of this disorder. Diabetes is a global crisis which affects the economy and health of all nations. Over the last decades, the number of individuals living with diabetes has significantly increased worldwide. Asia is a key epicenter of the emerging diabetes epidemic, with China and India the two nations having the highest number of diabetic people. Economic development, modernization, unhealthy diet, population aging, and sedentary lifestyles are the major factors responsible for the increasing diabetes epidemic. Diabetes is associated with several complications, and cardiovascular disease is the most important cause of morbidity and mortality among people with diabetes. These life-threatening problems can be prevented or delayed by proper management of diabetes. Lifestyle modification is an important factor to decrease the diabetes risk. The frequency of diabetic complications will rise if there is a lack of cost-effective and sustainable interventions. Hence, prevention of diabetes and its complications such as diabetic retinopathy and cardiovascular disease should be a crucial part of all future health-related public policies among all nations. This review summarizes current epidemiological aspects of diabetes in the world along with its complications, preventive measures, and treatment.

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“…On the other hand, yield of phytochemicals depends on parts of a plant (i.e. barks, leaves, flowers, roots, fruits or seeds) and their extraction methods [8][9][10][11][12][13]. DAM-1, methyl cinnamoyl catalpol, is obtained from methanolic extract of Dolichandrone atrovirens leaves having iridoid skeleton (type of monoterpenoids) (Fig 1).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a natural compound extracted from Dolichandrone atrovirens as a novel antioxidant agent using Caenorhabditis elegans

et al. 2021

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The compound methyl cinnamoyl catalpol (DAM-1) was isolated from the methanol extract of Dolichandrone atrovirens. Studies have already reported the antioxidant activity of Dolichandrone atrovirens bark extract, but till date the antioxidant activity of the isolated compound DAM-1, remains unexplored. The endogenous process of reactive oxygen species generation which leads to various degenerative diseases, can be broken down using these exogenous moieties from plant origin, herein this study we sought to evaluate the antioxidant potential of the DAM-1 compound using Caenorhabditis elegans (C. elegans), which is the primary model to study the antioxidant activity of compounds. Cytotoxicity assay results showed that DAM-1 treatment in the concentration of 10, 25 and 50 μg/ml has shown 100%, 91%, and 50% survival respectively with overall p<0.0001 (treatment v/s control group). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide–Formazan (MTT) assay results showed that treatment had better survival rates than the control group at different time intervals i.e. 48 h, and 72 h with p<0.01. Mechanosensation (behavioral study) as well as in vivo study results showed that at 0 h, 10 μg/ml of DAM-1 treatment showed a better anti-oxidative activity than the control group, 25 and 50 μg/ml of DAM-1 treated groups with p<0.001 but at 2.5 h incubation with 10, 25, 50 μg/ml of DAM-1 showed an increased anti-oxidative activity than the control group with p<0.001. Thermoresistance assay confirmed that the treatment group had more survival than control group with p<0.001. Absorption study of DAM-1 in C. elegans has shown that the absorption of the drug increases up to 180 mins with a slight decrease after 360 mins and then constant absorption up to 1440 mins. This study paves the way towards the initiative to explore the pharmacological role of DAM-1 in various oxidative stress mediated diseases at molecular levels and the absorption study points out its potential role which could be utilized in the metabolomics and proteomics analysis of this compound in other studies.

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Hypoglycemic herbs and their polyherbal formulations: a comprehensive review

Cited by 16 publications

References 23 publications

Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains

Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains

A Compendium of Perspectives on Diabetes: A Challenge for Sustainable Health in the Modern Era

Evaluation of a natural compound extracted from Dolichandrone atrovirens as a novel antioxidant agent using Caenorhabditis elegans

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