Hypoglycemic effect of aqueous extract of seabuckthorn (Hippophae rhamnoides L.) seed residues in streptozotocin‐induced diabetic rats

Abstract

An extract of seabuckthorn (Hippophae rhamnoides L.) seed residues has been shown to possess hypoglycemic and hypolipidemic properties in normal mice. The present study investigated the effects of an aqueous extract of seabuckthorn seed residues (ASSR) on serum glucose, lipid profiles and antioxidant parameters in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into four groups: a normal control group; diabetic control group; diabetic groups supplemented with 5 mg/kg body weight glibenclamide (reference drug) and 400 mg/kg body weight ASSR. Diabetes in rats was induced by intraperitoneal injection of streptozotocin (45 mg/kg body weight). Vehicle (distilled water), glibenclamide and ASSR were administered orally to normal and diabetic rats once a day lasting for 4 weeks. The data showed that administration of ASSR significantly lowered the serum glucose, triglyceride and nitric oxide levels in diabetic rats. Moreover, ASSR treatment also increased serum superoxide dismutase activity and glutathione level markedly. These results show that ASSR has hypoglycemic, hypotriglyceridemic and antioxidant effects in streptozotocin-induced diabetic rats, suggesting that ASSR supplementation can be useful in preventing diabetic complications associated with hyperlipidemia and oxidative stress.

Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin

“…In this investigation, the concentrations of MDA and NO were decreased after treating with TFE or TTE, indicating the inactivation of LPO reactions and the decreased free radical generation. Furthermore, in our study, the activities of SOD (a scavenger of free radicals) and GSH (a major endogenous antioxidant) decreased in diabetes group as reported earlier (Gokce and Haznedaroglu, 2008;Zhang et al, 2010) which could be due to inactivation caused by STZ-generated ROS. Treatment of diabetes with the TTE or TFE had reversed the activities of these enzymatic antioxidants, which might be due to decreased oxidative stress as evidenced by decreased LPO.…”

Evaluation of Antidiabetic and Antioxidant Effects of Seabuckthorn (Hippophae rhamnoides L.) in Streptozotocin-Nicotinamide Induced Diabetic Rats

“…In a recent study antidiabetic effect of an aqueous extract from SBT seed residues has been demonstrated [12].…”

“…Further, it is reported to be well tolerated and without any untoward reaction or side effects in toxicological studies [11]. It is interesting to note that SBT has recently been reported to possess hypoglycemic activity [12]. In view of all the above reports, we chose to evaluate SBT for possible beneficial effect on STZ-induced hyperglycemia and oxidative stress.…”

Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women

“…The studies concerning the effects of sea buckthorn (SB) and/or bilberry (BB) on metabolic diseases are presented below. In animal studies SB has shown positive effects on cardiovascular health (Yang et al, 2007;Pang et al, 2008;Koyama et al, 2009) and diabetes (Zhang et al, 2010). Also, positive effects of anthocyanin extract from blueberry on vascular health have been proposed based on in vitro (Bell and Gochenaur, 2006) and animal trials (Cohen-Boulakia et al, 2000).…”