Hypoglycemic and antihyperglycemic effect of Semecarpus anacardium
Linn in normal and streptozotocin-induced diabetic rats

Balasubramanian, A.; Ramalingam, Kothai; Christina, A. J. M.

doi:10.1358/mf.2004.26.10.872556

Cited by 38 publications

(17 citation statements)

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“…However, the BG and insulin levels of AEG were similar to those of EEG, suggesting that hypoglycaemic components in VBTL are soluble in both water and alcohol. This observation disagrees with the previous reports in which the hypoglycaemic component was soluble in either water (Kamalakkannan and Prince, 2003;Lee et al, 2008) or alcohol (Vetrichelvan et al, 2002;Arul et al, 2004). The difference may be attributed to there were two kinds of active components responsible for BG lowing activity, which can be soluble in water and alcohol, respectively.…”

Section: Discussioncontrasting

confidence: 99%

Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice

Wang

Zhang

et al. 2010

Journal of Ethnopharmacology

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Section: Discussioncontrasting

confidence: 99%

Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice

Wang

Zhang

et al. 2010

Journal of Ethnopharmacology

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“…The ethanolic extract of SA (100 mg/kg) reduced the blond glucose of normal rats The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment and antihyperglycemic activity of SA was compared with tolbutamide, a sulfonyl urea derivative used in diabetes mellitus. [36]…”

Section: Pharmacologymentioning

confidence: 99%

Semecarpus anacardium Linn.: A review

Semalty

Badola

et al. 2010

Phcog Rev

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Semecarpus anacardium Linn. (Family: Anacardiaceae), commonly known ‘Ballataka’ or ‘Bhilwa’, has been used in various traditional system of medicines for various ailments since ancient times. Its nuts contain a variety of biologically active compounds such as biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins and amino acids, which show various medicinal properties. The fruit and nut extract shows various activities like antiatherogenic, antiinflammatory, antioxidant, antimicrobial, anti-reproductive, CNS stimulant, hypoglycemic, anticarcinogenic and hair growth promoter. The article reviews the various activities of the plant.

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“…Studies have also reported that the drug has anti-inflammatory, antiarthritic, anthelmentic, antioxidative and anticancer activity [12, 13]. The nut milk extract has anticancer, hepatoprotective activity, anti-inflammatory, antioxidant property [14], and hypoglycemic activity [15]. Since Insulin suppresses hepatic glucose output by stimulating glycogen synthesis and inhibiting glycogenolysis and gluconeogenesis, a drug that would stimulate the insulin production or sensitize the peripheral tissues to insulin would be of beneficial effect to treat Diabetes Mellitus.…”

Section: Introductionmentioning

confidence: 99%

Semecarpus anacardium(Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats

Aseervatham

Shanthi

Sachdanandam

2011

Evidence-Based Complementary and Alternative Medicine

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Glucose produced by gluconeogenesis and glycogenolysis plays an important role in aggravating hyperglycemia in diabetes, and altered mitochondrial function is associated with impaired energy production. The present study focuses on the effect of Semecarpus anacardium on carbohydrate metabolism and energy production in diabetic rats. Diabetes was induced by the administration of Streptozotocin at a dose of 50 mg/kg.b.wt. Three days after the induction, Semecarpus anacardium at a dose of 300 mg/kg.b.wt was administered for 21 days. After the experimental duration, the activities of the enzymes involved in Glycolysis, TCA cycle, gluconeogenesis, and glycogen were assayed in the liver and kidney of the experimental animals. In addition, to the complexes the protein expression of AKT and PI3K were assayed. The levels of the enzymes involved in Glycolysis and TCA cycle increased, while that of gluconeogensis decreased. The activities of the mitochondrial complexes were also favorably modulated. The expressions of PI3K and AKT also increased in the skeletal muscle. These effects may be attributed to the hypoglycemic and the antioxidative activity of Semecarpus anacardium. The results of the study revealed that Semecarpus anacardium was able to restore the altered activities of the enzymes involved in carbohydrate metabolism and energy production.

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Hypoglycemic and antihyperglycemic effect of Semecarpus anacardium Linn in normal and streptozotocin-induced diabetic rats

Cited by 38 publications

References 0 publications

Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice

Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice

Semecarpus anacardium Linn.: A review

Semecarpus anacardium(Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats

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