Hypoglycemic Activity of the Extract and Fractions of <i>Anthocleista vogelii</i> (Planch) Stem Bark

Abstract

(64.10, 38.53, 36.50, 60.77 and 12.79 %, respectively) in FBG of the animals after 6 h, compared to 53.77 % for glibenclamide. Presence of alkaloids, carbohydrates, reducing sugars, saponins, flavonoids, glycosides, steroids, terpenoids, tannins, proteins, fats and oils were observed in ME, EF and AF. Alkaloids, flavonoids, steroids, terpenoids, fats and oil

Antidiabetic Activity and Toxicological Evaluation of the Methanol-Dichloromethane Root Bark Extract of Nauclea Diderrichii (De Wild) Merr

“…The previous study has shown the presence of alkaloid, flavonoids, saponins and other chemical compounds in the plant extract [24]. Several of these constituents are well known for their antidiabetic activity [25,26]. This suggests that the antidiabetic activity of the extract may be partly due to the action of these phytoconstituents which could act synergistically or independently in reducing the blood glucose level.…”

Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats

“…3 Researchers have found that over 200 pure phytochemicals are known to possess hypoglycaemic activity or insulin-potentiating action in vitro and in vivo. [4][5][6] Diabetes management devoid of side effects still poses a big challenge to the medical professionals. Therefore, the need to develop natural herbal products/alternatives with insulin-like bioactivity, having little or no side effects is imperative.…”

Comparative Anti-diabetic Activities of Methanol and n-Hexane Extracts of Anthocleistavogelii (Gentianaceae) Stem Bark in Normoglycemic and Alloxan-Induced Diabetic Rats

“…The results were analysed by the statistical package (SPSS 16.0) One Way Analysis of Variance (ANOVA) method, with Dunnet test for multiple comparisons compared to the control. Blood glucose concentrations at P < 0.05 and P < 0.01 were considered significant compared to the control [6].…”

“…Medicinal plants have been known to be relatively safe and less expensive in the management of diabetes [6].…”

“…In Nigeria, the bark and seed are used as an antipyretic and tonic. The acetone fraction of the methanol extract has been investigated to have significant antidiabetic activity [6] while the ethanol root extract has been investigated for anti-diabetic activity [8].…”