Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Abstract

The hypoglycemic effect of Lagerstroemia speciosa L. leaves hot water extract on chemically induced diabetes in rat was investigated. Experimental result showed that, streptozotocin significantly (p<0.001) elevated the normal blood sugar level whereas treatment with hot water extract depressed the streptozotocin-induced high blood sugar level about 43.2% as compare to diabetic controls. Treatment with hot water extract increased the activity of shunt enzyme glucose-6-phosphate dehydrogenase (33.8%) and glutathione level (31.3%) and depression of the activity of hepatic gluconeogenic enzymes glucose-6-phasphatase (31.6%) and fructose-1,6-bisphosphatase (27.4%). These studies thus strongly suggest that the hot water extract of L. speciosa leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis and stimulation of glucose oxidation using the pentose phosphate pathway.

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

“…Ethnopharmacological and ethno botanical surveys indicate that more than 1200 plants are used worldwide in herbal medicine to treat diabetes (Ziyyat et al, 1997;El-Hilaly et al, 2003;Tahraoui et al, 2007 (Prajapati et al, 2008;Ravi et al, 2009;Pattanayak et al, 2009;Tatiya et al, 2013;Bandara et al, 2009;Saha et al, 2009;Bhowmik et al, 2009;Sen et al, 2013;Khanam et al, 2009;Alamgeer et al, 2013;Bhavsar and Talele, 2013;Kulandaivel et al, 2013).…”

Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats

“…The plants kingdom has become a target for the search by multinational drugs and biological active lead compound. Ethnobotanical information indicates that a large number of plants show antidiabeic activity (Bandara et al, 2009;Bhowmik et al, 2009;Prajapati et al, 2008;Saha et al, 2009).…”

Effects of aqueous extract of <i>Fadogia agrestis</i> stem in alloxan-induced diabetic rats

“…Therefore, discovery and development of novel drugs from herbs will not be out of place. Herbal drugs or their extracts such as Cajanus scarabaeoides (Pattanayak et al, 2009), Lagerstroemia speciosa (Saha et al, 2009) and Teucrium stocksianum (Alamgeer et al, 2013), are prescribed widely even when their bioactive compounds are unknown (Gupta et al, 2005). Therefore, studies with plant extracts are useful in order to determine their efficacy, mechanism of action and bioactive agent(s) that are responsible for such pharmacological effect and safety.…”