Hypoglycemic action of an oral fig-leaf decoction in type-I diabetic patients

Serraclara, Alicia; Hawkins, Federico; Pérez, Carmen; Domı́nguez, Elisa; Campillo, J. E.; Torres, M.D.

doi:10.1016/s0168-8227(97)00112-5

Cited by 89 publications

(49 citation statements)

References 4 publications

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“…Meanwhile, studies on hypoglycemic effect of F. carica (FC) are limited to one study on rats with diabetes (20) and one study on 10 insulin-dependent humans (21). In consistence with the current study, Pérez et al suggested that FC extract decreased plasma glucose in rats with diabetes, and had a clear hypoglycemic effect in them.…”

Section: Discussionsupporting

confidence: 60%

Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Mazhin

Zaker

Shahbazian

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: It is advisable to pay sufficient heed to the high prevalence of diabetes mellitus (DM) management, which has heavy burden and remarkable impact on the patients' life quality. Objectives: The current study aimed to evaluate hypoglycemic effects of Ficus carica (FC) decoction (common fig leaf) in patients with type 2 DM. Patients and Methods: It was a double-blind cross-over clinical trial. There were two groups of 14 subjects. During the first phase of the study, one group received fig leaf decoction for 21 days and the other one received green tea as placebo. After a one-week wash-out period, the patients changed their medications and continued for another 21 days. Variables including fasting blood sugar (FBS), 2 hours postprandial blood sugar (2hpp), fructosamine, HbA1c, C-peptide, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed at baseline, and at the end of two phases of the study and were compared. Results: Thirteen patients in each group completed the trial. FBS, fructosamine, HbA1c, and C-peptide baseline and post-trial amounts

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Section: Discussionsupporting

confidence: 60%

Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Mazhin

Zaker

Shahbazian

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Medium average capillary profiles were also lower in patients during Ficus carica therapy versus non-sweet commercial tea. Average insulin dose was 12% lower during Ficus carica therapy in the total group [114].The aqueous decoction of fig leaves was treated with HCI, centrifuged, treated with sodium hydroxide (NaOH) and extracted with chloroform, the administration of the organic phase to rats with streptozotocin-induced diabetes led to a decline in the levels of total cholesterol and decrease in the total cholesterol/HDL cholesterol ratio compared to control group, together with a reduction of the hyperglycaemia [115].…”

Section: Antidiabetic Effectmentioning

confidence: 98%

Nutritional and pharmacological importance of Ficus carica - A review

Al-Snafi¹

2017

IOSRPHR

124

111

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Abstract:-The preliminary phytocemical analysis showed that the fruits of Ficus carica contained alkaloids, tannins, glycosides, flavanoids, saponins, coumarins, sterols, terpenes carbohydrates, phenols, essential oil, volatile oil, proteins and minerals. The previous pharmacological studies revealed that Ficus carica possessed antibacterial, antiviral, antiparasitic, antioxidant, anticancer, antimutagene, anti-angiogenic, antiinflammatory, antipyretic, antidiabetic, antiplatelet, reproductive, endocrine, immunological, dermatological, hypolipidemic, nootropic, antispasmodic, antidiarrheal, anti-warts, nephro-and hepato-protective effects. The current paper reviewed the chemical constituents, nutritional and pharmacological importance of Ficus carica.

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“…The leaves of this plant contain terpenoid, saponin and flavonoid compounds (el-Kholy and Shaban, 1966;Ahmed et al, 1988), which may be related to their alleged antiviral effects on herpes simplex virus (HSV), and hypoglycemic activity in type-I diabetic patients (Serraclara et al, 1998;Canal et al, 2000). But no study has yet reported the regulatory effects of F. carica leaf on osteogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells

Park

Eun

Choi

et al. 2009

Korean J Physiol Pharmacol

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Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast development depends critically on a differentiation factor, the receptor activator of NF-κB ligand (RANKL). In this study, we found that the hexane soluble fraction of the common fig Ficus carica (HF6-FC) is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells and in bone marrow-derived macrophages (BMMs). HF6-FC exerts its inhibitory effects by suppression of p38 and NF-κB but activation of ERK. In addition, HF6-FC significantly decreased the expression of NFATc1 and c-Fos, the master regulator of osteoclast differentiation. The data indicate that components of HF6-FC may have therapeutic effects on bone-destructive processes such as osteoporosis, rheumatoid arthritis, and periodontal bone resorption.

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Hypoglycemic action of an oral fig-leaf decoction in type-I diabetic patients

Cited by 89 publications

References 4 publications

Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Nutritional and pharmacological importance of Ficus carica - A review

Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells

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