Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Mazhin, Sadegh Ahmadi; Zaker, Marziyeh Asadi; Shahbazian, Hajieh; Azemi, Mohammad Ebrahim; Madanchi, Nima

doi:10.17795/jjnpp-25814

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Bio-efficacy testing in humans shows the decoction of leaves effectively controlled postprandial glycemia in individuals with T1DM (type 1 diabetes mellitus) [102]. Furthermore, a study by Mazhin et al (2016) showed that the addition of a fig leaf decoction, compared to oral hypoglycemic drugs, significantly decreased 2 h postprandial glycemia in patients with T2DM (type 2 diabetes mellitus) [103]. In another study, the effect of fig was compared with the oral drug metformin in people with T2DM [104] and this showed that metformin decreased blood sugar levels by 27.6% and figs decreased blood sugar levels by 13.5% after 2 months of treatment.…”

Section: Diabetes Benefitsmentioning

confidence: 99%

Phytochemical Composition and Health Benefits of Figs (Fresh and Dried): A Review of Literature from 2000 to 2022

et al. 2023

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With their rich history dating back 6000 years, figs are one of the oldest known plants to mankind and are a classical fruit in the Mediterranean diet. They possess a diverse array of bioactive components, including flavonoids, phenolic acids, carotenoids, and tocopherols, which have been used for centuries in traditional medicine for their health-promoting effects addressing gastrointestinal, respiratory, inflammatory, metabolic, and cardiovascular issues. This review summarizes the updated information on the phenolic composition, antioxidant capacity and other functional properties of fresh and dried figs cultivated in various parts of the world, highlighting variation in phenolic composition based on cultivar, harvesting time, maturity stage, processing, and fig parts. Additionally, the review delves into the bio-accessibility and bio-availability of bioactive components from figs and their potential influence on cardiovascular health, diabetes, obesity, and gut/digestive health. Data suggest that the intake of figs regularly in the diet, alone or with other dried fruits, increases select micronutrient intake and is associated with higher diet quality, respectively. Research in animal and human models of health and disease risk provide preliminary health benefits data on figs and their extracts from fig parts; however, additional well-controlled human studies, particularly using fig fruit, will be required to uncover and verify the potential impact of dietary intake of figs on modern day health issues.

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Section: Diabetes Benefitsmentioning

confidence: 99%

Phytochemical Composition and Health Benefits of Figs (Fresh and Dried): A Review of Literature from 2000 to 2022

et al. 2023

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Fig (Ficus caricaL.) leaf tea suppresses allergy by acceleration disassembly of IgE-receptor complexes

Abe

2020

Bioscience, Biotechnology, and Biochemistry

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In this study, I investigated the allergy suppressive effect of tea made from fig (Ficus carica L.) leaves. In the rat basophil cell line RBL-2H3, degranulation was significantly suppressed by treatment with fig tea at the same time as addition of IgE antibodies (sensitization). IgE bound to the cell surface was liberated in the medium depending on the treatment time with fig tea. Therefore, it was suggested that the mechanism of action of fig tea is promotion of dissociation of IgE from FcεRI receptors. Such a mechanism is novel in food materials. On oral administration to mice, fig tea showed an inhibitory effect on allergic dermatitis. Furthermore, in tests using an atopic dermatitis model in NC/Nga mice, continued administration of fig tea suppressed symptom exacerbation after antigen administration. Abbreviations AD: atopic dermatitis; β-Hex: β-hexosaminidase; FCM: flow cytometory; OA: oral administration; TA: transdermal administration

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Effects of Herbal Tea (Non–Camellia sinensis) on Glucose Homeostasis and Serum Lipids in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Alasvand Zarasvand,

Ogawa,

Nestor

et al. 2024

Nutrition Reviews

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Context Hyperglycemia and hyperlipidemia increase the risk for diabetes and its complications, atherosclerosis, heart failure, and stroke. Identification of safe and cost-effective means to reduce risk factors is needed. Herbal teas may be a vehicle to deliver antioxidants and polyphenols for prevention of complications. Objective This systematic review and meta-analysis were conducted to evaluate and summarize the impact of herbal tea (non–Camellia sinensis) on glucose homeostasis and serum lipids in individuals with type 2 diabetes (T2D). Data Sources PubMed, FSTA, Web of Science, CINAHL, MEDLINE, and Cochrane Library databases were searched from inception through February 2023 using relevant keyword proxy terms for diabetes, serum lipids, and “non–Camellia sinensis” or “tea.” Data Extraction Data from 14 randomized controlled trials, totaling 551 participants, were included in the meta-analysis of glycemic and serum lipid profile end points. Results Meta-analysis suggested a significant association between drinking herbal tea (prepared with 2-20 g d–1 plant ingredients) and reduction in fasting blood glucose (FBG) (P = .0034) and glycated hemoglobin (HbA1c; P = .045). In subgroup analysis based on studies using water or placebo as the control, significant reductions were found in serum total cholesterol (TC; P = .024), low-density lipoprotein cholesterol (LDL-C; P = .037), and triglyceride (TG; P = .043) levels with a medium effect size. Meta-regression analysis suggested that study characteristics, including the ratio of male participants, trial duration, and region, were significant sources of FBG and HbA1c effect size heterogeneity; type of control intervention was a significant source of TC and LDL-C effect size heterogeneity. Conclusions Herbal tea consumption significantly affected glycemic profiles in individuals with T2D, lowering FBG levels and HbA1c. Significance was seen in improved lipid profiles (TC, TG, and LDL-C levels) through herbal tea treatments when water or placebo was the control. This suggests water or placebo may be a more suitable control when examining antidiabetic properties of beverages. Additional research is needed to corroborate these findings, given the limited number of studies.

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Ficus carica Leaves Decoction on Glycemic Factors of Patients With Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial

Cited by 4 publications

References 14 publications

Phytochemical Composition and Health Benefits of Figs (Fresh and Dried): A Review of Literature from 2000 to 2022

Phytochemical Composition and Health Benefits of Figs (Fresh and Dried): A Review of Literature from 2000 to 2022

Fig (Ficus caricaL.) leaf tea suppresses allergy by acceleration disassembly of IgE-receptor complexes

Effects of Herbal Tea (Non–Camellia sinensis) on Glucose Homeostasis and Serum Lipids in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

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