Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits

Sharma, Suman; Nasir, Afreena; Prabhu, K. M.; Murthy, P. S.; Dev, Geeta

doi:10.1016/s0378-8741(02)00366-5

Cited by 270 publications

(225 citation statements)

References 14 publications

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“…With reference to the glycemia, the studies that were performed with seeds, fruit and bark of Syzygium cumini, following several different experimental patterns, demonstrated the hypoglycemic and anti-hyperglycemic effects (Achrekar et al, 1991;Ravi et al, 2004;Sharma et al, 2003;Sridhar et al, 2005;Villasenor & Lamadrid, 2006). Nevertheless, investigations carried out in Brazil have shown that the leaves and the fruits of Syzygium cumini did not have effect on diabetes (Pepato et al, 2005;Teixeira et al, 1990;Teixeira et al, 1997;Teixeira et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

“…This effect was related to the high contents of tannins in the extract, which would probably be responsible for the inhibition of the biosynthesis of prostaglandins (Muruganandan et al, 2001). The ethanolic extract of the S. cumini seeds has a hypoglycemic effect in diabetic rabbits, reducing the level of glucose and of the glycohemoglobin, and increasing the plasma levels of insulin (Sharma et al, 2003). This extract also presents a hypolipidemic effect, reducing the activity of the liver enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA) liver enzyme and therefore reducing the levels of cholesterol and triacylglycerides in the serum.…”

Section: Introductionmentioning

confidence: 99%

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The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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“…The plant belongs to Myrtaceae family and grows naturally in clayey loamy soil in tropical as well as in sub-tropical zones of Indo-gangetic plains. These species are reported to be very rich in tannins, flavonoids, essential oils, anthocyanins and other phenolic constituents (Sharma et al 2003;Reynertson et al 2008). The purple coloured fruits are available abundantly during summer season for a short span of time, causing a seasonal glut.…”

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confidence: 99%

Biochemical, microbiological and physiological changes in Jamun (Syzyium cumini L.) kept for long term storage under modified atmosphere packaging

Raj

Chadha²,

Kaur³

et al. 2011

J Food Sci Technol

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Jamun or Indian blackberry (Syzygium cumini L.) is a minor and highly perishable fruit enriched with flavonoids, essential oils, anthocyanins phenolic compounds and other antioxidants. The quantitative and qualitative losses in this seasonal fruit are tremendous and can be reduced by appropriate packaging and storage techniques which have not been applied hitherto. This study was undertaken to extend the shelf-life as well as to assess the biochemical, microbiological and physiological changes in jamun fruit under perforated and non-perforated modified atmosphere (MA) conditions. Fruits were stored under differential MA in macro-perforated (1 and 2 perforations, 0.3 mm dia. each) and non-perforated polypropylene (PP) film packages (Thickness: 35 μm, bag area: 0.036 m 2 ) at 5°C and 75% relative humidity (RH) for 23 days. Sachets containing white silica gel beads were placed inside all the packages to check water accumulation, if any. Different physiological, biochemical and microbiological characteristics which generally affect the postharvest life of the produce were monitored during the storage period. Results of the study suggested most of the subjectively and objectively determined qualitative parameters to be retained satisfactorily under macro-perforated packaging treatments. Further, the microbiological analysis, surmised that the fruits could be stored for long term using packages with 1 macro-perforation.Keywords Antioxidants . Jamun . Modified atmosphere packaging . Headspace . Pigments . Microbial load Indian blackberry (Syzygium cumini L.), commonly known as jamun is a minor and under-utilised tree-fruit of Indian subcontinent. The plant belongs to Myrtaceae family and grows naturally in clayey loamy soil in tropical as well as in sub-tropical zones of Indo-gangetic plains. These species are reported to be very rich in tannins, flavonoids, essential oils, anthocyanins and other phenolic constituents (Sharma et al. 2003;Reynertson et al. 2008). The purple coloured fruits are available abundantly during summer season for a short span of time, causing a seasonal glut. Jamun contains 19.7% carbohydrates, 0.7% proteins, 0.02% calcium, 0.1% fat, 0.01% phosphorous, 0.4% mineral matter, 0.1% iron and 0.9% fiber (Singh et al. 1967;Benherlal and Arumughan 2007). Besides, they contain anthocyanins which are the most important and widespread groups of colouring matters in plants. These intensely coloured water soluble pigments are responsible for nearly all colours in leaves, petals and fruits of higher plants. Jamun fruits and seeds are sweet, acrid and sour and they are used for treatment and control of diabetes, diarrhoea and ringworm. It is also reported to be a blood pressure regulator (Bhargava et al. 1968). Jamun trees are available around parks, on roadsides, on avenues and are good windbreakers. On account of its unorganised farming, consolidated information regarding its area and production in India is apparently not available. The fruits are highly perishable and are sold by the roadside vend...

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“…Studies with the seeds of S. cumini have already demonstrated hypocholesterolemic and hypotriglyceridemic effects (Sharma et al, 2003;Ravi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, studies with the seeds have shown that they reduce the plasma glucose levels in alloxan diabetic rats and rabbits; and a hypolipidemic effect has also been shown for this part of the plant (Sharma et al, 2003;Ravi et al, 2005). Investigations involving the bark have demonstrated that it causes a significant decrease in blood glucose levels in the glucose tolerance test (Villase˜nor & Lamadrid, 2006).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

Schoenfelder¹,

Warmlin²,

M³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Efeito hipoglicêmico e hipolipidêmico das folhas de Syzygium cumini Lam. em ratos diabeticos". Na região de Criciúma-SC, as folhas de Syzygium cumini (L.) Skeels, Myrtaceae, conhecida popularmente como jambolão, são utilizadas para diminuir níveis de glicose plasmática em pessoas diabéticas. Dentro deste contexto o presente trabalho teve o interesse de avaliar o efeito hipoglicêmico e hipolipidêmico do extrato bruto hidroalcoólico (EBH) das folhas de S. cumini (125, 250 e 500 mg/kg). Para tal os animais foram divididos em três grupos para o efeito hipoglicêmico: ratos normais, ratos normais submetidos a curva de glicose (hiperglicêmicos) e ratos diabéticos induzidos com aloxana. O efeito hipolipidêmico foi avaliado em animais diabéticos induzidos por aloxana. O efeito hipoglicêmico foi comparado com glibenclamida. O tratamento agudo com EBH de S. cumini causou uma diminuição estatisticamente significativa na glicose sanguínea em animais normais que foram submetidos à cura de glicose (250 mg/kg), e sobre os níveis de glicose (125 e 250 mg/kg), triglicerídeo (125 e 500 mg/kg) e colesterol (125 mg/kg) em animais diabéticos. Nenhuma das doses testadas apresentou efeito em animais normais. Dentro deste contexto pode-se sugerir que o EBH das folhas de S. cumini pode ser uma alternativa terapêutica no tratamento alternativo ou complementar na diabete, uma vez que apresentou atividade hipoglicêmica e hipolipidêmica em animais diabéticos.Unitermos: Syzygium cumini, Myrtaceae, diabete, hipoglicêmico, hipolipidêmico, plantas medicinais.ABSTRACT: Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals.

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Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits

Cited by 270 publications

References 14 publications

The toxicity evaluation of Syzygium cumini leaves in rodents

The toxicity evaluation of Syzygium cumini leaves in rodents

Biochemical, microbiological and physiological changes in Jamun (Syzyium cumini L.) kept for long term storage under modified atmosphere packaging

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

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