Hypoglycaemic activity of <i>Spathodea campanulata</i> stem bark decoction in mice

Niyonzima, G.; Beeck, L Van; Vlietinck, A. J.; Laekeman, Gert; Mets, Tony

doi:10.1002/ptr.2650070115

Cited by 19 publications

(13 citation statements)

References 15 publications

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“…Throughout the study, the animals were housed as six animals per polypropylene cage (435 × 285 × 150 mm) and maintained in a 12-h dark/light cycle at room temperature with constant relative humidity (Nixonzima and Vllietinck, 1993). The rats were fed a standard pellet diet (M/S Hindustan Liver Ltd, India) and drinking water was given ad libitum.…”

Section: Animalsmentioning

confidence: 99%

Protective effect of α‐lipoic acid against chloroquine‐induced hepatotoxicity in rats

Pari

Ponnusamy

2004

J of Applied Toxicology

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Oral administration of a-lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine-induced toxicity. Rats were treated orally with alpha-lipoic acid (10, 30 and 100 mg x kg(-1) day(-1)) for 7 days before a single oral administration of chloroquine (970 mg x kg(-1) day(-1)) and alpha-lipoic acid treatment was continued for three more days. The increased level of serum enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), bilirubin, lipids and plasma thiobarbituric acid-reactive substances (TBARS) and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with alpha-lipoic acid plus chloroquine. A significant decrease in plasma antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E were observed in chloroquine-treated rats when compared with control rats. Administration of alpha-lipoic acid significantly improved the levels of plasma antioxidants GSH, vitamin C and vitamin E in chloroquine-treated rats. In the case of 100 mg x kg(-1) day(-1) the effect was highly significant compared with the other doses (10 and 30 mg x kg(-1) day(-1)). The results of the study revealed that alpha-lipoic acid could offer protection against chloroquine-induced hepatotoxicity. alpha-Lipoic acid had a better protective effect when compared with silymarin, a reference drug.

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Section: Animalsmentioning

confidence: 99%

Protective effect of α‐lipoic acid against chloroquine‐induced hepatotoxicity in rats

Pari

Ponnusamy

2004

J of Applied Toxicology

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“…2 The oral glucose tolerance test is a well-accepted and frequently used assay to screen for hypoglycemic activity. 3 In diabetes mellitus, the proportion of glycosylated hemoglobin increases substantially, and the amount of glycosylated hemoglobin reflects the extent as well as management of the diabetic condition. 4 Recently, investigators found that several plants and plant products showed unique hypoglycemic activities in diabetic animal models.…”

Section: Introduction D Iabetes Mellitus Is An Endocrine Disordermentioning

confidence: 99%

Effect ofAegle marmelosFruits on Normal and Streptozotocin-Diabetic Wistar Rats

Kamalakkanan

Rajadurai

Prince

2003

Journal of Medicinal Food

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The present study evaluates the antidiabetic effect of an aqueous extract of Aegle marmelos fruits (AMFEt) in diabetes. Female albino Wistar rats were randomly divided into five groups: normal (untreated), normal + AMFEt, streptozotocin (STZ)-treated, STZ-treated + AMFEt, and STZ-treated + glibenclamide. Rats were rendered diabetic by STZ (45 mg/kg) administered intraperitoneally. AMFEt (250 mg/kg) was given twice daily for 1 month. Blood glucose, plasma insulin, glycosylated hemoglobin, liver glycogen, and change in body weight were determined. Food intake and water intake were monitored daily. An oral glucose tolerance test was also performed to determine the effect of this extract. The results show that glucose level and glycosylated hemoglobin were increased and plasma insulin and liver glycogen were decreased in diabetic rats, and that treatment with AMFEt reversed the effects of diabetes on these biochemical parameters to near-normal levels.

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“…In Ghana the leafy aerial parts are used to treat boils and sores (Ayensu, 1979;Burkhill, 1985). S. campanula is widely distributed in Africa and the bark is used traditionally as an antimalarial, hypoglycaemic agent and also for the treatment of ulcers (Irvine, 1961;Makinde et al, 1988;Niyonzima et al, 1993). Phytochemical investigation of S. campanulata bark has shown the presence of triterpenes and sterols (Ngouela et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

In Vitro evaluation of effects of two ghanaian plants relevant to wound healing

Mensah

Houghton

Dickson

et al. 2006

Phytotherapy Research

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Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC(50) value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 microg/mL and 10 microg/mL. The extracts showed no inhibition of NF-kappaB at 100 microg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.

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Hypoglycaemic activity of Spathodea campanulata stem bark decoction in mice

Cited by 19 publications

References 15 publications

Protective effect of α‐lipoic acid against chloroquine‐induced hepatotoxicity in rats

Protective effect of α‐lipoic acid against chloroquine‐induced hepatotoxicity in rats

Effect ofAegle marmelosFruits on Normal and Streptozotocin-Diabetic Wistar Rats

In Vitro evaluation of effects of two ghanaian plants relevant to wound healing

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