Effect ofAegle marmelosFruits on Normal and Streptozotocin-Diabetic Wistar Rats

Abstract

The present study evaluates the antidiabetic effect of an aqueous extract of Aegle marmelos fruits (AMFEt) in diabetes. Female albino Wistar rats were randomly divided into five groups: normal (untreated), normal + AMFEt, streptozotocin (STZ)-treated, STZ-treated + AMFEt, and STZ-treated + glibenclamide. Rats were rendered diabetic by STZ (45 mg/kg) administered intraperitoneally. AMFEt (250 mg/kg) was given twice daily for 1 month. Blood glucose, plasma insulin, glycosylated hemoglobin, liver glycogen, and change in body weight were determined. Food intake and water intake were monitored daily. An oral glucose tolerance test was also performed to determine the effect of this extract. The results show that glucose level and glycosylated hemoglobin were increased and plasma insulin and liver glycogen were decreased in diabetic rats, and that treatment with AMFEt reversed the effects of diabetes on these biochemical parameters to near-normal levels.

Ameliorative Anti-Diabetic Activity ofDangnyosoko, a Chinese Herbal Medicine, in Diabetic Rats

“…Generally, body weight decreases as diabetes progresses [23][24][25] but DNSK significantly and dose-dependently inhibited decrease in body weight 14 d from the Note that glucagon-producing cells were restricted to the peripheral regions of the pancreatic islets of sham. However, numerous cells were randomly distributed throughout the region of the pancreatic islets of diabetic control.…”

“…Sixty female Sprague-Dawley rats (6 weeks old on receipt, Charles River, Yokohama) were used after acclimatization for 7 d. The animals were placed five per polycarbonate cage in a temperature (20)(21)(22)(23)(24)(25) C) and humidity (40-45%) controlled room under a 12 h light-dark cycle, and feed (Samyang, Seoul, Korea) and water were supplied ad libitum. About half of the healthy animals were selected 3 d after STZ-dosing or sham injection based on blood glucose levels.…”

Anti-diabetic Activity of SMK001, a Poly Herbal Formula in Streptozotocin Induced Diabetic Rats: Therapeutic Study

“…Generally, body weight is decreased as progress of diabetes [25][26][27] but SMK001 significantly and dose-dependently inhibited the decrease of body weight from 14 d of dosing periods. Inhibits the body weight decrease is also considered as the indication of anti-diabetic activity of SMK001.…”

Anti-diabetic Activity of Methanol Leaf Extract of Costus pictus D. DON in Alloxan-induced Diabetic Rats

“…The prevention of depletion of glycogen in the liver tissue was possibly due to stimulation of insulin release from beta cells that activate the glycogen synthase system. 30,31) The lipid profiles in control and experimental rats are depicted in Table 3. In alloxan-induced diabetic rats, there was a significant (p < 0.001) increase of total cholesterol, triglycerides, phospholipids, and low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol and significant (p < 0.001) decrease in high-density lipoprotein (HDL) cholesterol in serum compared with normal control.…”