In Vitro evaluation of effects of two ghanaian plants relevant to wound healing

Abstract

Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC(50) value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 microg/mL and 10 microg/mL. The extracts showed no inhibition of NF-kappaB at 100 microg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

“…The anti-inflammatory activity of the extract tested using the chick carrageenan-induced foot oedema model. [16]. It also demonstrated protection of MRC-5 cells against oxidation by reactive oxygen species [17].…”

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

“…Some extrinsic factors are surgical technique, topical antiseptics and dressings 38 . Regarding wound dressings, several types have been developed based on plant herbs 39,40 , hydrocolloid, alginate and collagen 41 and can be applied as ointment, film 42 , foam and gel 43 for various purposes of treatment 44 . This manuscript reports on the development of a wound dressing for tissue repair based on bacterial cellulose and type I collagen.…”

Advanced Trends in Treatment of Wounds

“…A comparative study showed that a combination dressing is much more superior than a primary dressing. According to a trial, the efficacy achieved by the hydrocolloid was much better than that achieved by a paraffin gauze 15 . In another randomized trial, a comparison was made between a hydrocolloid dressing and a nonadherent dressing on patients suffering from lacerations and ulcers.…”