Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Shakir, K. A. Faseehuddin; Madhusudhan, Basavaraj

doi:10.1007/bf02912893

Cited by 33 publications

(21 citation statements)

References 17 publications

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“…It is known that the leakage of these intracellular hepatic enzymes into the blood stream is an indicator of hepatic cells damage frequently related to the susceptibility of their walls to oxidative stress (Das et al, 2010). Our findings are consolidated by previous studies in which flaxseed chutney has demonstrated a hepatoprotective function by decreasing liver marker enzymes GOT, GPT and ALP in the serum (Shakir and Madhusudhan, 2007a). Moreover, flax addition to the diet of rats exposed for a long-term to azoximethane, results in a significant decrease in liver -glutamyl transpeptidase profile and liver lipids and micronuclei formation (Shakir and Madhusudhan, 2007b).…”

Section: Blood Parameterssupporting

confidence: 68%

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Beroual¹,

Almasi‐Hashiani²,

Bachtarzi³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: The therapeutic safety of herbal medicine is a major concern for consumers and users. After studying the effects of linseed on hair growth in rabbits, the turn is to evaluate its safety by the observation of some clinical, biological and anatomo-pathological aspects. Materials and Methods: A study was conducted during a period of three months on two groups of rabbits (control and test). Test group daily received feed supplemented with 3g of ground linseed while the control animals received the same feed without any additives. Weekly, rabbits were weighed and monthly blood samples were taken. By the end of the trial, liver and kidneys biopsies were analyzed for histological and cytological lesions. Results: There was no significant improvement in weight gain in the test group rabbits, in which biochemical parameters had differentially evolved with a decrease in their Glycemia and cholesterolemia. There were also no modifications in their serum hepatic and renal marker enzymes and their liver and kidneys exhibited noticeably normal histology without any anatomically detectable anomalies. Conclusion: These findings confirm that prolonged linseed ingestion in rabbits is safe.

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Section: Blood Parameterssupporting

confidence: 68%

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Beroual¹,

Almasi‐Hashiani²,

Bachtarzi³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…A study on hypercholesterolemic rats fed on flaxseed chutney supplemented diet (15 %) revealed significant reduction in LDL cholesterol and total serum cholesterol and no change in HDL cholesterol. In CCl 4 intoxicated rats, lipid peroxidation products were neutralized by flaxseed lignans (Shakir and Madhusudan 2007). Several clinical studies showed that EPA and DHA play a major role in reducing depression symptoms.…”

Section: Metabolismmentioning

confidence: 99%

“…It is interesting to know that flaxseed was native of India and was a staple food crop. In India, flaxseed is still being consumed as food and as well as for medicinal purposes (Shakir and Madhusudan 2007). It enjoys a good status among oilseeds because of its versatile uses.…”

Section: Introductionmentioning

confidence: 99%

Flaxseed—a potential functional food source

2014

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There is currently much interest in phytochemicals as bioactive molecules of food. Functional foods are an emerging field in food science due to their increasing popularity among health conscious consumers. Flaxseed is cultivated in many parts of world for fiber, oil as well as for medicinal purposes and also as nutritional product. In this review, nutrients, anti-nutrients, functional properties, processing, metabolism and health benefits of bioactive molecules viz., essential fatty acids, lignans and dietary fiber of flaxseed are discussed.

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“…flax seed chutney was able to lower the cholesterol levels and shown the antioxidant protective effect against the carbon tetrachlorideinduced hepatotoxic damage in rats [46]. To check the effects of linseed consumption on lipid profile in rabbits on a hypercholesterolemic diet, investigators conducted an experimental study involving a total of 20 adult male white rabbits that were divided into two groups, a control and an experimental group.…”

Section: Animal Studiesmentioning

confidence: 99%

Effect of Phytoestrogens on Lipid Profile: Mini Review

Nagamma

Jagadeesh

Anjaneyulu

et al. 2017

Asian J Pharm Clin Res

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Phytoestrogens are structurally similar to its mammalian counterparts and are capable of producing estrogen-like effects and non-steroidal in nature. Their affinity to bind to the estrogen receptors, a class of cytoplasmic proteins, is far less in comparison to the natural estrogen hormones found in humans and other animals or even the synthetically prepared estrogen and, therefore, are far less potent. Even so, the usage of phytoestrogen in either dietary or supplemental form in postmenopausal women is gaining interest, as opposed to the conventional estrogen replacement therapy (ERT), which was so far being used to alleviate the postmenopausal symptoms and believed, with little experimental/clinical evidence, to cause a significant reduction in the threat of coronary heart diseases (CHD). This usage of phytoestrogen follows from the fact that the overall health risks exerted by ERT outweigh the benefits, and to a little extent, the perception that synthetically prepared, so-called "prescription estrogen" interferes with what is otherwise a natural process. It is crucial to explore the alternatives that mimic the beneficial effects of ERT, especially with regard to the minimization of the risk of developing CHD and further evaluation of the aforementioned risks in terms of lipid profiling while simultaneously keeping the health risks to a minimum. This review discusses the scope of use of phytoestrogen specifically pertaining to lipid profiling, their possible health benefits, and adverse effects if any.

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Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Abstract: Rats fed with hypercholesterolemic diet showed a significant increase in serum total -cholesterol, liver homogenate total -cholesterol, HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio

Cited by 33 publications

References 17 publications

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Flaxseed—a potential functional food source

Effect of Phytoestrogens on Lipid Profile: Mini Review

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