Hypocalcemia Due to Hypoparathyroidism in β-Thalassemia Major Patients

Aleem, Aamer; Almomen, Abdulkareem; Al-Harakati, Mohammed S.; Hassan, Asim; Al-Fawaz, I.

doi:10.5144/0256-4947.2000.364

Cited by 30 publications

(22 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They further observed that these patients were benefited with vitamin D and calcium supplementations. Aleem et al [13] also observed hypoparathyroidism in patients of Thalassemia. They suggested that hypoparathyroidism seen in these patients is due to chelation therapy.…”

Section: Resultsmentioning

confidence: 91%

See 1 more Smart Citation

Parathyroid and Calcium Status in Patients with Thalassemia

2010

View full text Add to dashboard Cite

Thirty patients with thalassemia major receiving repeated blood transfusion were studied to see their serum parathyroid hormone (PTH) and calcium status. Serum PTH, serum and 24 h urinary calcium, and serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were determined. Half of these patients, in addition to transfusion, were also supplemented with vitamin D (60,000 IU for 10d) and calcium (1500 mg/day for 3 months). Serum PTH, and serum and 24 h urinary calcium concentrations of the patients receiving transfusions were found to be significantly reduced while their serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were not significantly altered when compared to the respective mean values for the control group. Vitamin D and calcium supplementation significantly increased their serum PTH and calcium levels. Supplementations also increased urinary excretion of calcium. The results thus suggest that patients with thalassemia have hypoparathyroidism and reduced serum calcium concentrations that in turn were improved with vitamin D and calcium supplementation.

show abstract

Section: Resultsmentioning

confidence: 91%

“…Further, hypoparathyroidism in turn is also known to cause hypocalcemia. Several workers have reported reduced levels of PTH in patients with thalassemia [5,[12][13][14]. Autio et al [12] observed that 61% of their patients with b-thalassemia had hypocalcemia.…”

Section: Resultsmentioning

confidence: 99%

Parathyroid and Calcium Status in Patients with Thalassemia

2010

View full text Add to dashboard Cite

show abstract

“…Angelopoulos et al [82] in their study of transfusion dependant patients with β thalassaemia have demonstrated hypoparathyroidism in 13.5% subjects with significant low levels of intact parathyroid hormone and total and ionized calcium. Similarly Aleem et al [83] have shown that 20% of their patients had hypoparathyroidism which was much higher compared to the multicentre study in Italy [35] involving 25 centres which showed the prevalence to be 3.6%. A French study from 1993 showed the prevalence to be as high as 22.5% [84].…”

Section: Hypoparathyroidismmentioning

confidence: 85%

A Review of Endocrine Disorders in Thalassaemia

De¹,

Mistry²,

Wright³

et al. 2014

OJEMD

View full text Add to dashboard Cite

Endocrine dysfunction in thalassaemia is amongst the most common complication and is principally attributed to excessive iron overload and suboptimal chelation. The prevalence is quite high particularly in multiethnic populations but determining the prevalence is often difficult due to the widespread heterogeneity of the population and timing of exposure to chelation therapy. Disturbances in growth, pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes and disorderly bone growth are commonly encountered. Early detection and institution of appropriate transfusion regimen and chelation therapy and treatment of complications are the keys to managing this population including regular follow. In this article, we review the literature in relation to the various endocrine complications encountered in thalassaemia.

show abstract

“…Hypoparathyroidism is reported in 3.6-22.5% patients with thalassaemia major 8,9,11 . Majority of patients are asymptomatic while a few have mild symptoms 11 , as seen in our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Short stature and hypogonadism are common in patients with ferritin levels more than 2000µg/l 10 . Deposition of iron causes glandular damage due to free radical formation and lipid peroxidation causing mitochondrial, lysosomal and sarcolemmal membrane damage 11 . Therefore, it seems logical to consider that patients with high ferritin levels are more likely to develop endocrine complications, a feature seen in our patients with endocrine dysfunction (mean ferritin >5000ng/ml in most patients).…”

Section: Discussionmentioning

confidence: 99%

Endocrine abnormalities in children with Beta thalassaemia major

Joshi

Phatarpekar

2013

Sri Lanka J Child Health

View full text Add to dashboard Cite

Background: Endocrine complications in βthalassaemia major patients in developing countries are likely to occur at younger ages due to suboptimal iron chelation. Objective:To assess the prevalence of endocrine abnormalities and correlate serum ferritin, degree of anaemia and liver dysfunction with endocrine dysfunction Method: A cross sectional study was carried out in B. J. Wadia Hospital, over a period of 2 years, on all children with β-thalassemia major over the age of 4 years receiving regular blood transfusions. Patients with transfusion dependent anaemia other than βthalassemia major were excluded. Results:The total number of children over 4 years of age with β-thalassaemia major receiving regular blood transfusions during the study period was 135. Mean haemoglobin was 7.8 ± 0.6g/dl and the mean serum ferritin level 5295 ± 2736ng/ml. The most common endocrine abnormality was delayed puberty (68%). Seventy one (52.5%) patients had short stature with the height Z-score 2.8±0.8. Hypocalcaemia was observed in 40 (38%) patients. Ten (9.4%) patients had hypoparathyroidism while in 7 (6.6%) it was suspected based on hypocalcaemia, high phosphorus and normal alkaline phosphatase. Rickets was seen in 25 (23.5%) patients. Hypothyroidism was present in 22 (22%) patients of whom 14 had compensated hypothyroidism. Insulin resistance, impaired fasting glucose/impaired glucose tolerance (IFG/IGT) and diabetes mellitus were seen in 7.6%, 4.4% and 2.6% patients respectively. Mean age of patients with delayed puberty was 15.8±1, Eighteen (37.5%) patients had spinal osteoporosis. Five patients had more than one endocrine abnormality.Conclusions: There were no statistically significant differences between the patients with and without endocrine abnormalities with respect to serum ferritin, mean pre-transfusion haemoglobin and liver dysfunction except for ferritin in patients with hypoparathyroidism and diabetes mellitus.(

show abstract

Hypocalcemia Due to Hypoparathyroidism in β-Thalassemia Major Patients

Abstract: HPT due to iron overload may develop in a significant number of thalassemia major patients, especially when chelation therapy is not optimal, therefore, all thalassemics should be carefully watched for this complication from early in their second decade.

Cited by 30 publications

References 10 publications

Parathyroid and Calcium Status in Patients with Thalassemia

Parathyroid and Calcium Status in Patients with Thalassemia

A Review of Endocrine Disorders in Thalassaemia

Endocrine abnormalities in children with Beta thalassaemia major

Contact Info

Product

Resources

About