Parathyroid and Calcium Status in Patients with Thalassemia

Goyal, Meenu; Abrol, Pankaj; Lal, Harbans

doi:10.1007/s12291-010-0071-5

Cited by 32 publications

(29 citation statements)

References 14 publications

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“…In contrast with current study, there was no statistically significant variations in alkaline phosphatase levelsofblood transfusion dependent TMcases [21].…”

Section: Resultscontrasting

confidence: 99%

Study of Relationship Between Sp1 Polymorphism in the Collagen Type I Alpha -1 (Colia1) Gene and Osteoprosis in Patients With Beta-Thalassemia.

Khalifa¹,

Hesham²,

Elbaz³

et al. 2017

Zagazig University Medical Journal

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Background:-Osteoporosis is an important cause of morbidity in patients with β-thalassemia. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A 1(COLIA1) gene is thought to be an important factor in development of osteoporosis. Objective:-is to study the relationship between SP1 polymorphism in the collagen type 1 alpha 1 gene and the development of osteoporosis in patients with Beta thalassemia. Methods:-A total of 40 patients with β-thalassemia(21 females &19 males)aged 6-18 yearsand 40 healthy subjects cross matched with age and sex. Serum osteocalcin, serum alkaline phosphatase, calcium and DEXA were examined in all patients. The COLIA1 Sp1genotypes (SS, Ss, ss) were measured by digestion using restriction enzyme (Bal1) of DNA amplified by the polymerase chain reaction (PCR). Results:-SS (G/G) genotype in β-thalassemia major was30.7% and in β-thalassemia intermedia was 49.4% and the Ss (G/T) genotype in βT Major was 55.63% and in βT intermedia was 50.6%, the ss genotype (T/T) type in βTM was 13.67% only. The difference was statistically significant (p= 0.040). There was highly significant difference between thalassemia major and thalassemia intermedia compared to control group as regard Ca, OC, ALP and DEXA (P= 0.000). Conclusions:-Detection base substitutions at the Sp1 binding site on the COLIA1 gene in early years considering an important role in preventing osteoporosis in children with beta -thalassemia.and early mangment of these patients.

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“…In contrast with current study, there was no statistically significant variations in alkaline phosphatase levelsofblood transfusion dependent TMcases [21].…”

Section: Resultscontrasting

confidence: 99%

Study of Relationship Between Sp1 Polymorphism in the Collagen Type I Alpha -1 (Colia1) Gene and Osteoprosis in Patients With Beta-Thalassemia.

Khalifa¹,

Hesham²,

Elbaz³

et al. 2017

Zagazig University Medical Journal

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“…The use of regular transfusions with chelation has improved the quality of life in such patients but endocrine complications due to iron overload still do occur in these patients. [10] Socio-Demographic Characteristics: ( [11] in Missan province, in which it was found that the major type of thalasssemia was (78.97%) and the higher percentage affected were at age lower than 10 years(54%), (77.1%) according to Abdul-Karim, E. T., et al 2000 (12) in Iraq (64%) in…”

Section: Discussionmentioning

confidence: 99%

An Epidemiological Study of Thalassaemia Patients Attending Thalassaemic Center in Wassit Governorate

Al-kinani¹

2017

WJPR

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“…Limited data [87,88] shows that early supplementation with Vitamin D or calcitriol treatment for three months is sufficient to normalize plasma calcium and phosphate levels. Tetany, seizures or cardiac failure due to severe hypocalcaemia is rare and requires immediate correction with intravenous administration of calcium.…”

Section: Hypoparathyroidismmentioning

confidence: 99%

A Review of Endocrine Disorders in Thalassaemia

De¹,

Mistry²,

Wright³

et al. 2014

OJEMD

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Endocrine dysfunction in thalassaemia is amongst the most common complication and is principally attributed to excessive iron overload and suboptimal chelation. The prevalence is quite high particularly in multiethnic populations but determining the prevalence is often difficult due to the widespread heterogeneity of the population and timing of exposure to chelation therapy. Disturbances in growth, pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes and disorderly bone growth are commonly encountered. Early detection and institution of appropriate transfusion regimen and chelation therapy and treatment of complications are the keys to managing this population including regular follow. In this article, we review the literature in relation to the various endocrine complications encountered in thalassaemia.

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Parathyroid and Calcium Status in Patients with Thalassemia

Cited by 32 publications

References 14 publications

Study of Relationship Between Sp1 Polymorphism in the Collagen Type I Alpha -1 (Colia1) Gene and Osteoprosis in Patients With Beta-Thalassemia.

Study of Relationship Between Sp1 Polymorphism in the Collagen Type I Alpha -1 (Colia1) Gene and Osteoprosis in Patients With Beta-Thalassemia.

An Epidemiological Study of Thalassaemia Patients Attending Thalassaemic Center in Wassit Governorate

A Review of Endocrine Disorders in Thalassaemia

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