Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia

Parrish, Marc; Griffin, Meredith; Morris, Rachael; Darby, Marie; Owens, Michelle; Martin, James N.

doi:10.3109/14767058.2010.500429

Cited by 25 publications

(9 citation statements)

References 19 publications

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“…Several studies have reported a positive correlation between elevated maternal serum uric acid levels and adverse maternal and fetal outcomes. 4 - 8 , 25 - 27 There was disagreement in serum uric acid and serum creatinine as predictors of hypertensive disorders. Studies done by weerasekara D.S et al, Manjareeka M et al concluded that serum uric acid and serum creatinine are not predictive of pre-eclampsia and Thangaratinam S et al concluded that serum uric acid is not predictive of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women

Yalamati

Bhongir

Betha

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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BackgroundHypertensive disorders are the most common in pregnancy. Several studies showed a positive correlation between elevated maternal serum uric acid (UA), serum creatinine and adverse maternal and fetal outcomes, but only a few studies are available on serum cystatin C and maternal and fetal outcomes. The present study was undertaken to study the association of serum UA, creatinine and cystatin C with maternal and fetal outcomes.MethodsOut of 116 pregnant women 69 women had no hypertension and 47 had hypertension with or without proteinuria. Serum UA, creatinine and cystatin C was measured by modified Uricase method, modified kinetic Jaffe’s reaction and particle-enhanced immunonephelometric assay respectively. Multivariate logistic regression was performed to determine the independent effects of serum UA, creatinine and cystatin C on maternal and fetal outcomes using stata 13.1.ResultsThe adjusted odds ratio (OR) was 3.73 (95% CI: 1.18-11.75; P=0.024) for UA; 15.79 (95% CI: 3.04-81.94; P=0.001) for creatinine and 2.03 (95% CI: 0.70-5.87; P=0.192) for cystatin C in hypertensive disorders of pregnancy. All the three renal parameters were not significantly associated with birth weight, gestational age of delivery and mode of delivery after adjusting for the confounding factors.ConclusionsSerum creatinine and uric acid are independent risk factors for hypertensive disorders of pregnancy. High serum uric acid is associated with low birth weight and delivery by caesarian section whereas high serum creatinine with preterm delivery only before adjustment for confounding factors and not after adjustment. Serum cystatin C was not significantly associated with the maternal and fetal outcomes.

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Section: Discussionmentioning

confidence: 99%

Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women

Yalamati

Bhongir

Betha

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…In this study the i ncreased incidence of preterm delivery reflects the severity of disease rather than natural history. Most early deliveries with hypertension and proteinuria were medically indicated preterm inductions and births 13 . Among blood urea, serum creatinine and serum uric acid only latter was analyzed because hyperuricemia is a characteristic biochemical feature of preeclampsia known to be caused by an early tubular retention of urate which occurs before any measura ble decrease in the GFR 9,14. In the present study, the mean uric acid levels in the control group was found to be 3.07mg/dl., in the mild preeclampsia 4.03mg/dl, moderate-severe preeclampsia 5.57mg/dl and eclampsia 6.47mg/dl.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric acid level in preeclampsia and its correlation to maternal and fetal outcome.

Kamath

Nayak

Shantharam³

2014

Int Jour of Biomed Res

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“…International Journal of Gynecology & Obstetrics published by John Wiley &Sons Ltd on behalf of International Federation of Gynecology and Obstetrics levels play an important role in the prognosis of pre-eclampsia, [4][5][6] a unified threshold value has not been determined. Threshold values of 6 mg/dL (530.4 μmol/L) and 5.6 mg/dL for 38 weeks of gestation (521.4 μmol/L) have been reported 5,7 ; while Parrish et al 8 reported a mean uric acid level of 363.4 μmol/L in pregnancies with adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

Maternal serum uric acid concentration and pregnancy outcomes in women with pre‐eclampsia/eclampsia

Lê

Nguyen

Phan

et al. 2018

Intl J Gynecology & Obste

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Objectives To determine the relationship between maternal serum uric acid levels and fetal/neonatal complications in women with pre‐eclampsia/eclampsia, and to establish a predictive threshold value. Methods A diagnostic test and historical cohort study conducted by prospective cross‐sectional data collection on pregnant women with pre‐eclampsia/eclampsia at Hue University Hospital, Vietnam, between March 2015 and July 2017. Pre‐eclampsia was diagnosed based on ACOG criteria. Serum uric acid levels were measured by enzymatic colorimetric testing using a Cobas c 501 analyzer (Roche Diagnostics, Mannheim, Germany). Fetal complications included intrauterine growth restriction, preterm delivery, fetal death, and neonatal death. Results There were 205 women enrolled. Serum uric acid at a cutoff of 393 μmol/L is a good predictor of fetal/neonatal complications (AUC 0.752), with 64.4% sensitivity and 79.5% specificity. High uric acid level (≥393 μmol/L) resulted in increased risk of preterm birth (OR 6.367, 95% CI 3.009–13.084), low Apgar scores (OR 5.514, 95% CI 1.877–16.198), intrauterine growth restriction (OR 7.188, 95% CI 3.592–14.382), and neonatal death (OR 7.818, 95% CI 1.614–37.867). There was no relationship between uric acid level and fetal death (OR 1.803, 95% CI 0.355–9.168). Conclusions Maternal serum uric acid concentration is a good predictor of fetal/neonatal outcomes in women with pre‐eclampsia/eclampsia.

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Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia

Abstract: Maternal hyperuricemia is a better predictor of maternal than perinatal risk and adverse outcome.

Cited by 25 publications

References 19 publications

Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women

Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women

Serum Uric acid level in preeclampsia and its correlation to maternal and fetal outcome.

Maternal serum uric acid concentration and pregnancy outcomes in women with pre‐eclampsia/eclampsia

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