Maternal serum uric acid concentration and pregnancy outcomes in women with pre‐eclampsia/eclampsia

Lê, Thạch Ngọc; Nguyen, Long H.; Phan, Nam L.; Le, Duong Dinh; Nguyen, Huy; Truong, V.Q.; Cao, Thanh Ngoc

doi:10.1002/ijgo.12697

Cited by 30 publications

(20 citation statements)

References 10 publications

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“…However, a significant rise in TAC in the case group women in comparison to the control group during the 3 rd trimester pregnancy was noted (p<0.0001). Similarly, increased TAC levels were reported by Hermawan et al (p<0.01) and Le et al (p<0.001) in pregnant women with eclampsia cases when compared to women having a normal pregnancy [20,21] . There are conflicting reports in literature with respect to the antioxidant levels in connection to the placental syndrome, where some studies show decreased and some show increased circulating antioxidant levels [22][23][24][25][26] .…”

Section: Discussionsupporting

confidence: 65%

Study of uterine artery perfusion and total antioxidant capacity in second trimester pregnancy

Reddy¹,

Bk²,

Mn³

2021

Int. J. Clin. Obstet. Gynaecol.

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Background: Abnormal placentation during the 1 st trimester results in oxidative stress, affecting the subsequent gestational course. This study evaluated if the condition of pathological perfusion is distinguished by an altered plasma antioxidant capacity along with investigating the efficacy of total antioxidant capacity (TAC) measurement as an adjunct to doppler sonography. Methodology: Pregnant women (2 nd trimester), categorized into 2 groups [Control (n=25, normal uterine perfusion) and case (n=25, abnormal uterine perfusion)], were evaluated for TAC. Statistical significance was set at p≤0.05. Results: Mean plasma TAC was higher in the control (750.02±74.12 µmol/l) than the case group (580.97±168.37 µmol/l) (p<0.0001). Difference in the mean period of gestation between groups was significant (p<0.0001). The gestation period and birth weight in case group was lower than that of control. Conclusion: Hindered uterine perfusion causing reduced plasma TAC levels was observed. Estimating TAC may have diagnostic, pathophysiologic and therapeutic implications concerning abnormal uterine perfusion.

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Section: Discussionsupporting

confidence: 65%

Study of uterine artery perfusion and total antioxidant capacity in second trimester pregnancy

Reddy¹,

Bk²,

Mn³

2021

Int. J. Clin. Obstet. Gynaecol.

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“…This may be explained as Cystatin C does not pass the placental barrier and there is no significant correlation between maternal and neonatal levels,unlike creatinine level [26]. [27].…”

Section: Discussionmentioning

confidence: 99%

Renal Function Tests in Women with Preeclampsia with and without Intrauterine Growth Restriction

Sadeq¹,

Mohammed²,

Hussein³

et al. 2020

IJFMT

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Background:The kidney is the most likely to be affected by endothelial injury in patients with preeclampsia, so assessment of renal function is essential in the evaluation of the pregnant women with preeclampsia. Aim of the study: to evaluate which test of renal function in preeclamptic patients with and without intrauterine growth restriction is more useful. Patients and method:150 women in third trimester with preeclampsia over period of 14 months diagnosed based on measurement of blood pressure and presence of proteinuria divided into two group : group A those preeclamptic women without feature of intrauterine growth restriction by ultrasound and Doppler study and group B those with features of intrauterine growth restriction. Blood aspirated from each woman and blood urea, serum creatinine, serum uric acid, and serum cystatin-C were measured using spectrophotometer. Results: From 150 women with preeclampsia 120 of them had no features of intrauterine growth restriction and 30 had some features. Mean maternal age of patients included was 22±0.3 in group A and 24±0.7 in group B which is not differ statistically while the body mass index should statistically differences between the two group with P value <0.001. the blood urea, serum creatinine and serum uric acid levels found to be higher in group B but not reach statistical differences while serum cystatin C are higher in group B mean 1.23±0.45when compared to group A 1.08±0.97with p value <0.001. Conclusion:Renal function may be affected more in patients with intrauterine growth restriction and cystatin C level is more promising marker for renal function in preeeclamptic women.

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“…Uric acid could be used as risk marker for progression to preeclampsia and development of adverse maternal or infant condition. [29][30][31] Johnson et al 32 stated that uric acid more than 5.2 mg/dL had excellent sensitivity, specificity, and likelihood ratios for diagnosis and prognosis of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Maternal Characteristics, Pregnancy, and Neonatal Outome in Preeclampsia and HELLP Syndrome: a Comparative Study

Sungkar¹,

Irwinda²,

Surya³

et al. 2021

ejki

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HELLP syndrome is a complication in pregnancy which may increase maternal morbidity and mortality risk. This study aims to compare maternal characteristics, pregnancy and neonatal outcome between preeclampsia and HELLP syndrome. All preeclampsia without or with severe features and HELLP syndrome using ACOG criteria coming to dr. Cipto Mangunkusumo Hospital from January 2015 to December 2017 were recruited into this cross-sectional study. Demographic, clinical, laboratories parameters, and neonatal outcomes were compared between HELLP and preeclampsia patients. The SPSS 20 for Windows was used for all analyses. There were 676 deliveries which was complicated by preeclampsia without or with severe features and 113 patients with HELLP syndrome. Gestational age, history of hypertension systolic and diastolic blood pressure, hemoglobin, hematocrit, urea, creatinine, uric acid, and albumin are different significantly between HELLP and preeclampsia patients. History of hypertension in previous pregnancy is considered as a significant risk factor for HELLP syndrome (p=0.001); RR 2.33 (95% CI 1.41–3.9). Based on data of gestational age at delivery which lower in HELLP syndrome, it showed lower median birth weight in HELLP syndrome (1442.5 g) compared with preeclampsia (1442.5 g vs 2400 g, p=; 95%CI There is significant difference in gestational age at delivery, nullipara, blood pressure, and laboratory findings (urea, creatinine, uric acid, albumin) between preeclampsia and HELLP syndrome group. History of hypertension in previous pregnancy is a significant risk factor for HELLP syndrome. Regarding neonatal outcome, baby born from HELLP syndrome has lower median birth weight. Keywords: HELLP syndrome, preeclampsia, risk factor, neonatal outcome. Karakteristik Maternal, Luaran Kehamilan, dan Neonatal pada Preeklamsia dan Sindrom HELLP: Studi Komparatif Abstrak Sindrom HELLP merupakan komplikasi kehamilan yang meningkatkan morbiditas dan mortalitas maternal. Studi ini bertujuan untuk mengetahui perbedaan karakteristik antara sindrom HELLP dan preeklamsia serta luaran neonatus. Studi potong lintang ini melibatkan seluruh pasien preeklamsia dengan atau tanpa perburukan dan sindrom HELLP berdasarkan kriteria ACOG yang datang ke RS dr. Cipto Mangunkusumo pada bulan Januari 2015 sampai Desember 2017. Analisis bivariat digunakan untuk mengetahui hubungan karakteristik demografi, klinis, laboratorium antara pasien HELLP dan preeklamsia sedangkan analisis multivariat untuk mengetahui karakteristik yang memengaruhi sindrom HELLP. Data dianalisis menggunakan SPSS 20. Terdapat 676 persalinan pada kelompok preeklamsia dengan atau tanpa perburukan dan 113 pasien dengan sindrom HELLP. Usia kehamilan, tekanan darah sistolik dan diastolik, hemoglobin, hematokrit, ureum, kreatinin, asam urat, dan albumin berbeda bermakna antara pasien sindrom HELLP dan preeklamsia. Riwayat hipertensi pada kehamilan sebelumnya dianggap sebagai faktor risiko terhadap sindrom HELLP (p=0,001); RR 2,33 (IK 95% 1,41-3,9). Berdasarkan usia kehamilan saat persalinan yang lebih awal dan bayi lahir lebih rendah pada sindrom HELLP (1442,5 g) dibandingkan preeklamsia (2400 g). Terdapat perbedaan bermakna pada usia kehamilan saat persalinan, tekanan darah, dan parameter laboratorium (ureum, kreatinin, asam urat, albumin) antara kelompok preeklamsia dan sindrom HELLP. Berdasarkan luaran neonatus, bayi dari sindrom HELLP lebih rendah berat lahirnya. Kata kunci: sindrom HELLP, preeklamsia, faktor risiko, luaran neonatus

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Maternal serum uric acid concentration and pregnancy outcomes in women with pre‐eclampsia/eclampsia

Cited by 30 publications

References 10 publications

Study of uterine artery perfusion and total antioxidant capacity in second trimester pregnancy

Study of uterine artery perfusion and total antioxidant capacity in second trimester pregnancy

Renal Function Tests in Women with Preeclampsia with and without Intrauterine Growth Restriction

Maternal Characteristics, Pregnancy, and Neonatal Outome in Preeclampsia and HELLP Syndrome: a Comparative Study

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