Serum Uric acid level in preeclampsia and its correlation to maternal and fetal outcome.

Kamath, Rajalaxmi K; Nayak, Radhakrishna; Shantharam, Manjula

doi:10.7439/ijbr.v5i1.457

Cited by 12 publications

(11 citation statements)

References 12 publications

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“…(7.3±2.7 mg/dl) and Kamath et al (5.57 mg/dl) that in preeclampsia, SUA levels rise significantly when compared to normal pregnant women. 12,13 Maternal complications were noted to be higher in hypertensive pregnant women, especially so with SUA levels≥5 mg/dl as compared to those with < 5 mg/dl in our study. Significant correlation exists between elevated SUA (above 5 mg/dl) and 24 hrs proteinuria, abruption placentae, HELPP syndrome or deranged coagulation profile etc in this study, an observation also reported by Pereira et al and Nischintha et al 14,15 Hyperuricemia in the setting of gestational hypertension is associated with adverse fetal outcome.…”

Section: Discussionsupporting

confidence: 40%

Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

Saldanha¹,

Malik²,

Quraishi³

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders represent the most common medical complication of pregnancy affecting between 7-15% of all gestations and accounts for approximately a quarter of antenatal admissions.Methods: A case-control study was conducted over a period of 1 year. A total of 200 subjects were enrolled in the study and were divided into two groups; 100 cases and 100 controls. Serum uric acid levels were measured in cases and controls. The serum uric acid levels were correlated with the severity of PIH and maternal and fetal complications.Results: It was observed that the mean serum uric acid level in cases (5.0±1.74 mg/dl) was significantly higher compared to 2.66±0.39 mg/dl in controls. Serum uric acid levels also tended to increase with increasing severity of PIH, increasing from 3.69±0.95 mg/dl in gestational hypertension to 6.36±1.38mg/dl in severe PE. Maternal complications during antepartum and postpartum period were higher once SUA≥5mg/dl was taken as a cut-off. Protienuria(p=0.00), coagulopathy(p=0.007), need for blood/platelet transfusion(p=0.01) and eclampsia (p= 0.007) were significantly more. Similarly, complications were found to be higher, in babies born to mothers having serum uric acid more than 5 mg/dl compared to others in case group.Conclusions: Higher serum uric acid levels may indicate higher risk of progression to preeclampsia and development of adverse maternal/infant conditions.

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Section: Discussionsupporting

confidence: 40%

Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

Saldanha¹,

Malik²,

Quraishi³

2018

Int J Reprod Contracept Obstet Gynecol

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“…Due to the glomerular filtration become impaired proteinuria develops. An increase in plasma urete is therefore an early sign in the evolution of preeclampsia [19]. In the present study the significantly higher levels of uric acid levels are observed in preeclamptic women when compared to controls.…”

Section: Resultssupporting

confidence: 61%

“…In the present study we observed significant differences in systolic and diastolic blood pressure (p=0.00) as well as urinary protein-they were higher in preeclamptic pregnant women than in the control groups (p=0.00), and this is expected as regards the basis of diagnosing pre-eclampsia. Increase in oxidative stress markers has been implicated to damage the maternal vascular endothelium leading to the elevation in diastolic pressure which further aggravates the condition of preeclamptic patients [18,19]. The imbalance between oxidative damage and antioxidant defences in pre-eclampsia leads to endothelial cell dysfunction and it appears to be a central feature in the patho-physiology of preeclampsia [17].…”

Section: Resultsmentioning

confidence: 99%

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Dyslipidemia and Anti-Oxidative System in Preeclamptic Women at Rural Area of Rayalasema

Annaldasula¹,

Durgaprasad²

2017

IJIMS

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“…The analysis of a combination of biomarkers particularly markers related to vascular dysfunction such as LDH may enrich the ability to predict and prevent preeclampsia in near future. 15 So the present study is aimed at comparing the LDH levels in normotensive and pre-eclamptic women and to correlate its levels with maternal and perinatal outcome in pre-eclampsia.…”

mentioning

confidence: 99%

Lactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcome

Bhandari

Gupta

Kharb

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorder of pregnancy occurs in approximately 6-8% of all pregnancies. The most serious consequences for the mother and the baby are the result of preeclampsia and eclampsia. Lactate Dehydrogenase (LDH) is an intracellular enzyme. Recently LDH has been suggested as potential marker to predict severity of pre-eclampsia. The objective of the present study was to compare the serum lactate dehydrogenase levels in women with preeclampsia and normal pregnant women and to correlate lactate dehydrogenase levels with maternal and perinatal outcome in preeclampsia.Methods: An observational prospective study was conducted on 200 antenatal women attending the labour room emergency. Women with singleton pregnancy and cephalic presentation, from 28 weeks onwards were enrolled in the study. Out of 200, 100 were normal pregnant women and 100 were preeclamptic women. Serum LDH levels were measured in all women and maternal and perinatal outcome was assessed in terms of LDH levels.Results: Higher levels of LDH was observed in pregnant women with preeclampsia (627.38±230.04 IU/l) as compared to normal pregnant women (224.43±116.61 IU/l). The maternal complications were found to be maximum in women with LDH > 800 IU/l. Abruption was the most common complication. The perinatal mortality and neonatal deaths were found to have significant correlation with high LDH levels.Conclusions: Maternal and perinatal complications were associated with higher LDH levels in preeclampsia patients. Serum LDH levels can be offered to all patients of preeclampsia and can be used to predict the prognosis of preeclampsia.

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Serum Uric acid level in preeclampsia and its correlation to maternal and fetal outcome.

Cited by 12 publications

References 12 publications

Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

Dyslipidemia and Anti-Oxidative System in Preeclamptic Women at Rural Area of Rayalasema

Lactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcome

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