Hypertriglyceridemic-waist is more predictive of abnormal liver and renal function in an Australian population than a Chinese population

Yu, Dahai; Wei, Yang; Chen, Tao; Cai, Yamei; Zhao, Zhanzheng; Simmons, David

doi:10.1016/j.orcp.2018.07.010

Cited by 9 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decline in eGFR was related with the increased risk of mortality and end-stage renal disease (ESRD) [29]. Only a few studies have determined the association of decreased eGFR risk with triglyceride waist phenotypes [21], and shown that HTGW was associated with abnormal renal function among both Chinese and Australian subjects. In the present large Chinese population, we also observed similar findings in overall and stratified populations; NTGW phenotype was also associated with an increased risk of reduced eGFR.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

et al. 2020

View full text Add to dashboard Cite

Background: Hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD). However, there is limited evidence on the relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity. Our aim was to explore the associations of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults. Methods: A population-based, cross-sectional study was conducted among Chinese participants aged 20-74 years from June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m 2 was defined as decreased eGFR. HTGW phenotype was defined as triglyceride (TG) ≥1.7 mmol/L and a waist circumference (WC) of ≥90 cm for men and ≥ 80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models. Results: A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW) and elevated TG level/enlarged WC (HTGW) phenotypes were associated with the increased risk of decreased eGFR. Multivariable-adjusted ORs (95% CI) associated with NTGW, elevated TG level/normal WC (HTNW), and HTGW phenotypes were 1.75 (1.41-2.18), 1.29 (0.99-1.68), and 1.99 (1.54-2.58), respectively. These associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. HTGW phenotype was consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk. Conclusions: HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages, except for severely decreased eGFR. Further prospective studies are warranted to confirm our findings and to investigate the underlying biological mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

“…While another cross-sectional study in elderly participants reached an opposing conclusion [17]. Thus far, limited evidence suggest increased risk of decline renal function with HTGW [21]. Previous studies were limited by the lack of stratified analyses.…”

Section: Introductionmentioning

confidence: 97%

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Study participants' body mass index was calculated by their body weight (unit: kg) divided by the square of their height (unit: meter). Study participants with BMI ≥25 kg/m 2 was defined as overweight [9]. Blood samples were collected for all participants after an overnight fasting for at least 10 h by trained nurse.…”

Section: Clinical Measurementsmentioning

confidence: 99%

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults

Shi

Cai

Qin

et al. 2020

BMC Cardiovasc Disord

Self Cite

View full text Add to dashboard Cite

Background: There is uncertain evidence in the dose-response association between overall physical activity levels and clustering of cardiovascular diseases modifiable risk factors (CVDMRF) in Chinese adults. This study examined the hypothesis whether inverse dose-response association between overall physical activity levels and clustering of CVDMRF in Chinese adults exist. Methods: Twenty-six thousand ninety-three Chinese adult participants were recruited by two independent surveys in Nanjing and Hefei during 2011 to 2013, from random selected households provided smoking, glucose, lipids, anthropometric, and blood pressure measurements. Logistic regression model was applied to examine the doseresponse association between overall physical activity (measured by metabolic equivalent task (MET)-minutes per week) and having ≥1, ≥2, and ≥ 3 CVDMRF (dyslipidemia, hypertension, diabetes, cigarette smoking, and overweight). Results: An inverse linear dose-response relationship between physical activity and clustering of CVDMRF was identified, as increased physical activity levels are associated with lower odds of having clustering of CVDMRF. The adjusted odds ratio (95% confidence interval) of having ≥1, ≥2, and ≥ 3 CVRF for moderate physical activity group and high physical activity group was 0.88 (0.79 to 0.98) and 0.88 (0.79 to 0.99), 0.85 (0.78 to 0.92) and 0.85 (0.78 to 0.92), 0.84 (0.76 to 0.91) and 0.81 (0.74 to 0.89), respectively, with low physical activity as reference group. Conclusions: Among Chinese adults, physical activity level inversely associates with clustering of CVDMRF, especially in those aged 35-54 years. Health promotion including improve physical activity should be advocated. The potential role of physical activity in the clustering of CVDMRF warrants further validation.

show abstract

“…The decline in eGFR was related with the increased risk of mortality and end-stage renal disease (ESRD) [27]. Only a few studies have determined the association of decreased eGFR risk with triglyceride waist phenotypes [19], and shown that HTGW was associated with abnormal renal function among both Chinese and Australian subjects. In the present large Chinese population, we also observed the similar findings in overall and all stratified population; NTGW and HTNW phenotype were also associated with an increased risk of reduced eGFR.…”

Section: Discussionmentioning

confidence: 99%

“…While another cross-sectional study in elder participants reached opposite conclusions [15]. Limited evidence suggested increased risk of decline renal function with HTGW [19], and previous studies was limited by the lack of stratified analyses.…”

Section: Introductionmentioning

confidence: 97%

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

Qiu

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD), but evidence on relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity is limited. Our aim was to explore the association of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults.Methods: A population-based, cross-sectional study was conducted among Chinese participants aged 20-74 years during June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as Decreased eGFR. The HTGW phenotype was defined as a triglycerides (TG) level ≥1.7 mmol/L and a waist circumference (WC) ≥90 cm for men and ≥80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models.Results: A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW), elevated TG level/enlarged WC (HTGW) were associated with the increased risk of decreased eGFR, with an multivariable-adjusted ORs (95% CI) of 1.77 (1.42-2.20), 1.48 (1.16-1.90), and 2.30 (1.80-2.93), respectively. These positive associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. NTGW, HTNW, and HTGW phenotype were consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk.Conclusions: HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages except for severely decreased eGFR. The findings imply that HTGW may be an important risk factor for renal dysfunction or an indicator for prevention and control aiming to reduce renal function decline.

show abstract

Hypertriglyceridemic-waist is more predictive of abnormal liver and renal function in an Australian population than a Chinese population

Cited by 9 publications

References 22 publications

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults

Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

Contact Info

Product

Resources

About