Hyperthyroidism Treated With Methyl Thiouracil

FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND11

“…6-Methylthiouracil has been tested in animals (Chapman, 1944) and man (Leys, 1945) and in agreement with the above findings it proved to be comparable to thiouracil in activity. Higgins and Larsen (1944) first reported the goitrogenic action of promizole in guinea pigs and rats and recently Williams (1945) has found that tetramethylthiourea and to a lesser degree diethylthiourea are effective in the treatment of hyperthyroidism in man when administered in doses of 0.6 to 1.0 gm.…”

Abnormalities in taste preference in hypothyroid rats.

“…quinine sulfate; NaCl preference; thyroxine THE OBSERVATION that the sense of taste in man may be disturbed in hypothyroidism was made by physicians more than fifty years ago (16). Later, drugs used in the treatment of hyperthyroidism were noted to reduce and to alter taste acuity (9, 15,25), but whether these effects were due to the drugs themselves or to the production of hypothyroidism was not clarified. Recently (17), defects involving each of four taste qualities have been demonstrated to occur in the majority of a group of patients with hypothyroidism, and these changes were improved by treatment with thyroid hormones.…”

Thiouracil in the Treatment of Thyrotoxicosis

“…From the great sequence of workers from Astwood in 1943 to Leys in 1945 there has come a practically unbroken chorus of praise for the good effects of thiourea, thiouracil, and methyl thiouracil in the treatment of thyrotoxicosis; there are, however, some few (Joll; Morley, 1944) who are not entirely of that mind. To this more critical view we ourselves would incline, while fully realizing the great value of thiouracil in the treatment of most cases of thyrotoxicosis.…”