FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND<sup>1</sup><sup>1</sup>

Astwood, E. B.; Bissell, Adele; Hughes, Amy

doi:10.1210/endo-37-6-456

Cited by 165 publications

(78 citation statements)

References 4 publications

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“…It is known that thiocarbonamides-chemically related to PTC -block the intrathyroidal synthesis of thyroxine [Astwood, 1943]. Goitrogens, also related to PTC, are found in cruciferous plants [Clements, 1960], and there is evidence that cow's milk during the winter months contains an antithyroid substance with similar thyroid-blocking properties as the thiocarbonamides [Greene et at., 1958].…”

Section: Discussionmentioning

confidence: 99%

PTC Taste Sensitivity in Toxic Diffuse Goitre

Persson¹,

Kølendorf²,

Kølendorf³

1972

Hum Hered

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Section: Discussionmentioning

confidence: 99%

PTC Taste Sensitivity in Toxic Diffuse Goitre

Persson¹,

Kølendorf²,

Kølendorf³

1972

Hum Hered

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“…Gleichzeitige Gabe von Thyroxin hob diese Wirkungen auf. Bereits nach 70 mg/kg Thioharnstoff, oral über 10 Tage gegeben, kommt es zu einer Vermiderung des Jodgehaltes von 73 auf 23 mg/100 g Schilddrüse [24], und 1% Thioharnstoff für 2 Monate im Futter führten zu einer verminderten Jodaufnahme in die Schilddrüse [25]. Im Zusammenhang mit der Unterfunktion der Schilddrüse fanden sich erhöhte Hypophysengewichte mit histologischen und biochemischen Hinweisen einer Überfunktion sowie Gewichtsverminderungen von Ovarien, Uterus und Prostata [26][27][28] …”

Section: Subakute Und Subchronische Toxizitätunclassified

Thioharnstoff [MAK Value Documentation in German language, 1988]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 14. Lieferung, Ausgabe 1988 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Therapeutische Erfahrung zur Dosis‐Wirkungs‐Beziehung Tierexperimentelle Befunde Akute Toxizität Subakute und subchronische Toxizität Chronische Toxizität Untersuchungen zur kanzerogenen Wirkung Pharmakokinetik, Meiabolismus und Mechanismus der Wirkung auf Schilddrüse, und andere Organe Schilddrüse Lunge Aktivierung durch isolierte Enzyme Reaktion mit Sauerstoff‐Radikalen Nichtenzymatische Reaktionen Untersuchungen zur gentoxischen Wirkung Mitogene Wirkung Mutagenität DNA‐Reparatur in Hepatozyten Induktion von DNA‐Strangbrüchen Hemmung der DNA‐Synthese Gegenwärtiger Kenntnisstand hinsichtlich gentoxischer Wirkungen Reproduktionstoxizität Zur Frage eines MAK‐Wertes

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“…www.seipub.org/bab Biochemistry and Biophysics (BAB), Volume 3, 2017 Other reports have proven that PTU-induced thyroid blockade is leveled by KI [1], but the underlying mechanisms of this effect are not yet well established [17]. It is possible that determination of intrathyroidal iodine under acute effect of iodide after PTU administration by means of EPMA would help to better understand these mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Potassium Iodide after Propylthiouracil Administration: Contents of Iodine and Selenium in the Thyroid, Pituitary, Adrenal Glands and Ovaries of Female Rats

Basalaeva¹,

Гарбузов²,

Стрижиков³

et al. 2017

Biochemistry and Biophysics

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The purpose of this study was to determine the contents of iodine and selenium in the thyroid, pituitary, adrenal glands and ovaries of female rats under the influence of propylthiouracil (PTU) and the effects of a single dose of potassium iodide (KI) administered two days after the administration of PTU. For the analyses, electron probe microanalysis (EPMA), wavelengthdispersive spectrometry (WDs) and point analysis were used in this study. Ninety-six hours after the first PTU administration the thyroid gland iodine level decreased three-fold in iodide positive points (I-PPs) and the percentage of positive points (%I-PPs) fell by one half. Administration of a single dose of potassium iodide slightly increased the iodine level in I-PPs and restored %I-PPs to the control level. After PTU administration the selenium positive points (Se-PPs) in the thyroid gland decreased by one half, but KI did not help to level these changes. In ovaries, pituitary and adrenal glands PTU administration did not significantly alter the average levels of iodine and selenium, but the Se-PPs and % I-PPs varied over a wide range. Administration of KI restored the levels of iodine and selenium in the pituitary and adrenal glands, but worsened the changes of iodine in ovaries.

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FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND¹¹

Cited by 165 publications

References 4 publications

PTC Taste Sensitivity in Toxic Diffuse Goitre

PTC Taste Sensitivity in Toxic Diffuse Goitre

Thioharnstoff [MAK Value Documentation in German language, 1988]

Acute Effects of Potassium Iodide after Propylthiouracil Administration: Contents of Iodine and Selenium in the Thyroid, Pituitary, Adrenal Glands and Ovaries of Female Rats

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FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND11

Cited by 165 publications

References 4 publications

PTC Taste Sensitivity in Toxic Diffuse Goitre

PTC Taste Sensitivity in Toxic Diffuse Goitre

Thioharnstoff [MAK Value Documentation in German language, 1988]

Acute Effects of Potassium Iodide after Propylthiouracil Administration: Contents of Iodine and Selenium in the Thyroid, Pituitary, Adrenal Glands and Ovaries of Female Rats

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FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND¹¹