1999
DOI: 10.1159/000026986
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Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results

Abstract: There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40–44 °C) of cells or tumor tissues. Based upon these results the integration of hyperthermia as an additional treatment modality, given simultaneously with systemic chemotherapy or in combination with radiochemotherapy, is currently tested at the clinic. Regional hyperthermia combined with chemotherapy or r… Show more

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Cited by 60 publications
(43 citation statements)
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References 43 publications
(36 reference statements)
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“…MHT (41-44°C), while non toxic to cancer cells in and of itself, has been demonstrated to increase the efficacy of chemotherapy in both in vitro and in vivo experiments [23,25,26]. The effects on either F98 or ACBT spheroid growth, of the drugs BLM and 5-FU at 37°C and 44°C were compared.…”
Section: The Effect Of Mht On Drug Toxicitymentioning
confidence: 99%
“…MHT (41-44°C), while non toxic to cancer cells in and of itself, has been demonstrated to increase the efficacy of chemotherapy in both in vitro and in vivo experiments [23,25,26]. The effects on either F98 or ACBT spheroid growth, of the drugs BLM and 5-FU at 37°C and 44°C were compared.…”
Section: The Effect Of Mht On Drug Toxicitymentioning
confidence: 99%
“…The thermo-chemotherapy results in a more efficient therapeutic effect, increases the target specificity and reduces the systemic side effects [92]. Synergy has been observed with a combination of hyperthermia and chemotherapy for deep seated tumors [93][94][95].…”
Section: Introduction and Interpretation Of A Relative "Old Method" Imentioning
confidence: 99%
“…elliptical multi-antenna applicators in conjunction with MRI-control, will expand the heatable regions to the abdomen. A general overview on other methods to increase temperature (interstitial, endocavitary, part body, whole body hyperthermia or isolated limb perfusion), combined thermochemotherapy and technical developments are given in 4 up-to-date reviews [12][13][14][15].…”
Section: Deep Regional Thermoradiotherapymentioning
confidence: 99%