Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results

Issels, R. D.

doi:10.1159/000026986

Cited by 60 publications

(43 citation statements)

References 43 publications

(36 reference statements)

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“…MHT (41-44°C), while non toxic to cancer cells in and of itself, has been demonstrated to increase the efficacy of chemotherapy in both in vitro and in vivo experiments [23,25,26]. The effects on either F98 or ACBT spheroid growth, of the drugs BLM and 5-FU at 37°C and 44°C were compared.…”

Section: The Effect Of Mht On Drug Toxicitymentioning

confidence: 99%

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

Christie

Molina

Gonzales

et al. 2016

Biomed. Opt. Express

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Combination therapies of photochemical internalization (PCI) and moderate hyperthermia (MHT) were investigated in an in vitro system consisting of human and rat glioma spheroids. PCI using the amphiphilic photosensitizer, AlPcS2a and two anti cancer agents BLM or 5-FU were used. Spheroids were irradiated with λ = 670 nm laser light in an incubator at temperatures ranging from 37 to 44°C. For each temperature investigated, spheroids were divided into 4 groups: control, drug-only, photodynamic therapy (PDT), and PCI. PDT and PCI spheroids were exposed to radiant exposures ranging from 0.3 to 2.5 J cm −2 using an irradiance of 5 mW cm −2 . Toxicity was evaluated from spheroid growth kinetics. The combination of PCI and MHT resulted in significant increases in BLM efficacy at 44°C for both cell line derived spheroids compared to controls at 37°C over the range of radiant exposures examined. 5-FU PCI was ineffective for the human cell line at both 37 and 44°C. L. West, "Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance," Proc. Natl. Acad. Sci. U.S.A. 100(23), 13549-13554 (2003). 31. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, "Determination of the minimum temperature required for selective photothermal destruction of cancer cells with the use of immunotargeted gold nanoparticles," Photochem. Photobiol. 82(2), 412-417 (2006). 32.

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Section: The Effect Of Mht On Drug Toxicitymentioning

confidence: 99%

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

Christie

Molina

Gonzales

et al. 2016

Biomed. Opt. Express

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“…The thermo-chemotherapy results in a more efficient therapeutic effect, increases the target specificity and reduces the systemic side effects [92]. Synergy has been observed with a combination of hyperthermia and chemotherapy for deep seated tumors [93][94][95].…”

Section: Introduction and Interpretation Of A Relative "Old Method" Imentioning

confidence: 99%

What is on the Horizon for Hyperthermic Cancer Therapy?

GyP¹,

Dy²,

Hegyi³

2017

J Tradi Med Clin Natur

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“…elliptical multi-antenna applicators in conjunction with MRI-control, will expand the heatable regions to the abdomen. A general overview on other methods to increase temperature (interstitial, endocavitary, part body, whole body hyperthermia or isolated limb perfusion), combined thermochemotherapy and technical developments are given in 4 up-to-date reviews [12][13][14][15].…”

Section: Deep Regional Thermoradiotherapymentioning

confidence: 99%

Current and Potential Role of Thermoradiotherapy for Solid Tumours

et al. 2003

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The disappointing results for inoperable, locally advanced or recurrent solid tumours of the uterine cervix, rectum, chest wall, liver and deep seated, high-risk sarcomas after conventional radiotherapy alone necessitate the search for improved treatments. A benefit from simultaneous radiochemotherapy with regard to local tumour control and survival has been shown for a rising number of tumour entities. Radiofrequency hyperthermia is established in only a few centres, and represents another option to intensify the effect of radio- and chemotherapy. Altogether 11 randomised phase III trials with more than 1,000 patients proved the combination of hyperthermia (40–42 °C for at least 1 h) and radiation therapy in reference to local tumour control. Two of these trials could demonstrate a survival benefit; e.g. in locally advanced cervical cancer, stage FIGO IIB–IVa, the 3-year survival was improved from 27 to 51% with the addition of hyperthermia. Frequently trial design (main endpoint local tumour control), a low number of patients or a short follow- up period are the reasons why most trials of thermoradiotherapy failed to demonstrate a survival benefit. Disadvantageous effects of hyperthermia like an increased rate of distant metastases as a result of hyperthermia-induced elevated perfusion can be largely ruled out. While at the moment the equivalence of thermoradiotherapy and radiochemotherapy is still under evaluation, future studies have to investigate the question whether hyperthermia can add benefits when used in combination with simultaneous radiochemotherapy. An ongoing investigation of hyperthermia in multimodal treatment strategies for locally advanced solid tumours is warranted. These trials will help to improve temperature monitoring and temperature distribution and define particular groups of patients who will profit from the addition of hyperthermia. The ‘Interdisziplinäre Arbeitsgruppe Hyperthermie’, a working group of the German Cancer Society, introduces clinical protocols, treatment devices, and provides information for patients at www.hyperthermie.org.

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Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results

Cited by 60 publications

References 43 publications

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

What is on the Horizon for Hyperthermic Cancer Therapy?

Current and Potential Role of Thermoradiotherapy for Solid Tumours

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