Hypertension, single sugars and fatty acids

Valensi, P.

doi:10.1038/sj.jhh.1001954

Cited by 24 publications

(24 citation statements)

References 37 publications

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“…Intake of the fructose-containing beverages led to reduced (compensatory) chow intake, but – in contrast to our study – to greater final body weights than the rats drinking water or glucose-containing beverages [33]. It has been shown that high dietary fructose consumption (fructose 60%/wt in chow) leads to a stress response in the liver, insulin resistance, and hyperlipidemia [34] as well as increased sympathetic neural activity, blood pressure, and elevated uric acid levels [35,36]. In contrast to those studies, we did not observe onset of steatosis or fibrosis of the liver, as mentioned above.…”

Section: Discussionmentioning

confidence: 68%

Effect of moderate intake of sweeteners on metabolic health in the rat

Figlewicz

Ioannou

Jay

et al. 2009

Physiology & Behavior

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The rise in prevalence of obesity, diabetes, metabolic syndrome, and fatty liver disease has been linked to increased consumption of fructose-containing foods or beverages. Our aim was to compare the effects of moderate consumption of fructose-containing and non-caloric sweetened beverages on feeding behavior, metabolic and serum lipid profiles, and hepatic histology and serum liver enzymes, in rats. Behavioral tests determined preferred (12.5–15%) concentrations of solutions of agave, fructose, high fructose corn syrup (HFCS), a combination of HFCS and Hoodia (a putative appetite suppressant), or the non-caloric sweetener Stevia (n=5/gp). HFCS intake was highest, in preference and self-administration tests. Groups (n=10/gp) were then assigned to one of the sweetened beverages or water as the sole source of liquid at night (3 nights/wk, 10wks). Although within the normal range, serum cholesterol was higher in the fructose and HFCS groups, and serum triglycerides were higher in the Agave, HFCS, and HFCS/Hoodia groups (vs. water-controls, p<0.05). Liver histology was normal in all groups with no evidence of steatosis, inflammation, or fibrosis; however serum alanine aminotransferase was higher in the fructose and HFCS groups (vs. water-controls, p<0.05). Serum inflammatory marker levels were comparable among Stevia, agave, fructose, HFCS, and water-consuming groups, however levels of IL-6 were significantly lower in association with the ingestion of Hoodia. There were no differences in terminal body weights, or glucose tolerance assessed by 120-min IVGTTs performed at the end of the 10-week regimen. We conclude that even moderate consumption of fructose-containing liquids may lead to the onset of unfavorable changes in the plasma lipid profile and one marker of liver health, independent of significant effects of sweetener consumption on body weight.

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Section: Discussionmentioning

confidence: 68%

Effect of moderate intake of sweeteners on metabolic health in the rat

Figlewicz

Ioannou

Jay

et al. 2009

Physiology & Behavior

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“…O aumento do consumo de carboidratos simples pode produzir uma leve e transitória elevação da pressão arterial por meio da ativação simpática, principalmente em indivíduos hipertensos (Valensi, 2005).…”

Section: Carboidratosunclassified

Epidemiologia nutricional

Kac¹,

Sichieri²,

Gigante³

2007

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“…The research has shown that food with a high content of fructose may increase the triglyceride level in plasma as well as cause hyperinsulinaemia, insulin resistance, increased blood pressure, and heart diseases [17, 18]. In the conducted research, the influence of the dosage of Aronia juice on the changes caused in brain tissue by the increased amount of fructose and saturated fats was assessed [19].…”

Section: Introductionmentioning

confidence: 99%

Aronia melanocarpaTreatment and Antioxidant Status in Selected Tissues in Wistar Rats

Francik

Krośniak

Sanocka

et al. 2014

BioMed Research International

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Aronia juice is considered to be a source of compounds with high antioxidative potential. We conducted a study on the impact of compounds in the Aronia juice on oxidative stress in plasma and brain tissues. The influence of Aronia juice on oxidative stress parameters was tested with the use of a model with a high content of fructose and nonsaturated fats. Therefore, the activity of enzymatic (catalase, CAT, and paraoxonase, PON) and nonenzymatic (thiol groups, SH, and protein carbonyl groups, PCG) oxidative stress markers, which indicate changes in the carbohydrate and protein profiles, was marked in brain tissue homogenates. Adding Aronia caused statistically significant increase in the CAT activity in plasma in all tested diets, while the PON activity showed a statistically significant increase only in case of high fat diet. In animals fed with Aronia juice supplemented with carbohydrates or fat, statistically significant increase in the PON activity and the decrease in the CAT activity in brain tissue were observed. In case of the high fat diet, an increase in the number of SH groups and a decrease in the number of PCG groups in brain tissue were observed.

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Hypertension, single sugars and fatty acids

Cited by 24 publications

References 37 publications

Effect of moderate intake of sweeteners on metabolic health in the rat

Effect of moderate intake of sweeteners on metabolic health in the rat

Epidemiologia nutricional

Aronia melanocarpaTreatment and Antioxidant Status in Selected Tissues in Wistar Rats

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