Hypertension is Common among HIV-Infected Persons, But Not Associated with HAART

Medina-Torne, Sheila; Ganesan, Anuradha; Barahona, Irma; Crum-Cianflone, Nancy F.

doi:10.1177/1545109711418361

Cited by 61 publications

(53 citation statements)

References 27 publications

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“…The highest number of studies were from Norway 5,23,25,26 and United States of America. 6,8,29,36 The total mean age was 39.2 years (30 studies [n = 32 374 patients]), with patients in high-income countries being older than those in low-and middleincome settings (mean age = 40.4 versus 37.8 years). Among the ART-exposed patients, the overall mean duration of treatment was 37.5 months (23 studies (n = 36 423)).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 573 abstracts and 17 full texts, including seven duplicate records, were excluded, leaving 39 eligible observational studies. [5][6][7][8]15,16, Thirty of these included studies were cross-sectional surveys, 5,16,[18][19][20][21][22][23][24][25][26]28,[31][32][33][34][35][36][37][39][40][41][42][44][45][46]48,49 whereas the other nine were cohort studies. A total of 44 903 HIV-infected patients (28% females) from 21 countries were included in our analyses, with significantly more study participants from high-income countries compared with low-and middle-income countries (89% versus 11%).…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] In addition, no systematic evidence has provided comprehensive estimates of the impact of ART exposure on blood pressure levels and hypertension risk. We therefore set out to address this gap in the current body of evidence by performing a systematic review and meta-analysis to compare blood pressure levels and hypertension risk between HIV-infected patients naive and exposed to ART.…”

Section: Introductionmentioning

confidence: 98%

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Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy: a systematic review with meta-analysis

et al. 2015

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Owing to antiretroviral drug-induced endothelial dysfunction, HIV-infected patients on antiretroviral therapy (ART) may have elevated blood pressure. We conducted a systematic review and meta-analysis to estimate the effects of ART on blood pressure levels and hypertension risk among HIV-infected populations worldwide. We sought articles that compared the mean blood pressure measurements and hypertension prevalence between HIV-infected adults naive and exposed to ART. Thirty-nine studies comprising 44 903 participants met the inclusion criteria. Overall, systolic (mean difference (MD) 4.52 mm Hg, 95% confidence interval (CI) 2.65-6.39, I(2)=68.1%, 19 studies) and diastolic blood pressure levels (MD 3.17 mm Hg, 95% CI 1.71-4.64, I(2)=72.5%, 16 studies) were significantly higher among ART-exposed patients compared with treatment-naive patients. Similarly, the risk of hypertension was significantly higher among ART-exposed patients, such that among 28 908 ART-exposed patients, 4195 (14.5%) had hypertension compared with 950 of 9086 (10.5%) in those who were treatment-naive (odds ratio 1.68, 95% CI 1.35-2.10, I(2)=81.5%, 32 studies). In summary, exposure to ART is significantly associated with increased systolic and diastolic blood pressure levels, and increased risk of hypertension, regardless of study-level sociodemographic differences. This meta-analysis supports the need for population-based strategies to reduce the risk of high blood pressure among people living with HIV on ART.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy: a systematic review with meta-analysis

et al. 2015

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“…Muhammad et al (2013) reported a prevalence of 17% of hypertension cases in HIV patients mainly on NNRTI-based HAART during 6-84 months. In Western countries, many studies showed hypertension proportion among HIV patients on HAART ranging from 13% to 34% (Gazzaruso et al, 2003;Jung et al, 2004;Bergersen et al, 2003;Medina-Torne et al, 2012;Savès et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

Biological and clinical abnormalities leading to cardiovascular disease during antiretroviral treatment in a university hospital in Abidjan

Kouakou-Siransy¹,

Horo²,

Effo³

et al. 2015

Int. J. Bio. Chem. Sci

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Antiretroviral drugs are involved in the occurrence of adverse effects. In Côte d'Ivoire, HIV1 treatment protocols are non-nucleoside reverse transcriptase inhibitors based. No study has been undertaken in the country about cardiovascular risk. Thus, the objective of our study was to assess the prevalence of biological abnormalities and clinical markers of cardiovascular risk during antiretroviral therapy. We conducted a prospective cross-sectional study with 238 patients who were on antiretroviral treatment including nonnucleoside reverse transcriptase inhibitors for at least 6 months in the Pneumophtisiology department of the university hospital of Cocody (Abidjan). Metabolic syndrome was determined according to NCEP-ATP III criteria. Biological parameters investigated were: triglyceride, HDL cholesterol and LDL, glucose and clinical parameters: blood pressure and waist circumference. Eleven patients (4.62%) have a metabolic syndrome, 17.6% had hypertriglyceridemia. An increase in LDL cholesterol and lower HDL-cholesterol were found in both cases in 13.9% of patients and an atherogenic index greater than 4.5 in 5% of patients. Hyperglycemia occurred during antiretroviral therapy in 28% of the study population. Patients who developed hypertension and increased waist circumference during antiretroviral therapy were 9.75% and 15.5% respectively. Our results testify to the potential existence of a cardiovascular risk during the non-nucleoside inhibitor used.

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“…Hypertension is associated with established risk factors, and is common among HIV-infected individuals. The high prevalence of hypertension has been associated with duration of HIV infection, whereas virally-mediated endothelial changes or immune activations may play a role [20].…”

Section: Discussionmentioning

confidence: 99%

Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Takaki¹,

Quirelli²,

Cuman³

2017

Trop. J. Pharm Res

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79 (35.9 %). Gastrointestinal disorders (25.9 %), hypertension (25.4 %), and neuropsychiatric symptoms (18.2 %) were the most common clinical ADRs. The most common laboratory-based ADRs were anemia (48.8 %), hypertriglyceridemia (47.3 %), hypercholesterolemia (36.1 %) and hyperglycemia (22.6 %). Conclusion:The results demonstrate a high incidence of ADRs in HIV-patients treated with HAART, which should be monitored closely during follow-up therapy.

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Hypertension is Common among HIV-Infected Persons, But Not Associated with HAART

Cited by 61 publications

References 27 publications

Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy: a systematic review with meta-analysis

Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy: a systematic review with meta-analysis

Biological and clinical abnormalities leading to cardiovascular disease during antiretroviral treatment in a university hospital in Abidjan

Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

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