Hypertension alone or related to the metabolic syndrome in postmenopausal women

Nuzzo, Annachiara; Rossi, Rosario; Modena, Maria Grazia

doi:10.1586/erc.10.147

Cited by 23 publications

(16 citation statements)

References 49 publications

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“…The reason for rising blood pressure levels at menopause is multifactorial and not completely understood. There are several hypotheses that include the role of sex hormones, the renin–angiotensin system, weight gain, and sympathetic activation [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic and metabolic effects of estrogen plus progestin therapy in hypertensive postmenopausal women treated with an ACE-inhibitor or a diuretic

et al. 2014

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ObjectivesThe aim of the study was to assess the hemodynamic and metabolic actions of estrogen plus progestin therapy (EPT) in hypertensive, postmenopausal women treated with perindopril (ACEI) or hydrochlorothiazide (HCTZ). A group of normotensive postmenopausal women was also studied.Methods100 hypertensive and 40 normotensive postmenopausal women were recruited for the study. The hypertensive females were randomly assigned to receive ACEI or HCTZ for 12 months. The patients of the ACEI group and the patients of the HCTZ group, as well as normotensives, were further subdivided into two subgroups each. One subgroup received estrogen plus progestin therapy (EPT+), the other subgroup received no hormone replacement (EPT−). Combined hormone replacement with transdermal patches releasing 17β-estradiol and norethisterone was used. Office and 24-hour ambulatory blood pressure was measured at baseline and during follow-up. Renal plasma flow (RPF) was measured using the clearance of [125I]-iodohippuran. Pulse wave velocity (PWV) was determined with an automatic device.ResultsIn normotensive postmenopausal women, transdermal estrogen plus progestin therapy increases RPF and insulin sensitivity, decreases PWV, decreases total and LDL cholesterol, and decreases uric acid serum levels. Perindopril (4 mg/day) and hydrochlorothiazide (25 mg/day) were equally effective in reducing blood pressure in postmenopausal, hypertensive subjects. In these females, perindopril increased RPF and decreased PWV and plasma insulin levels. These effects of the ACEI were not altered by estrogen plus progestin therapy. Hydrochlorothiazide decreased RPF and increased plasma insulin and uric acid concentrations in hypertensive subjects whom were not receiving estrogen plus progestin therapy.ConclusionsThe unfavorable metabolic and hemodynamic actions of the diuretic were counteracted by estrogen plus progestin therapy. Concomitant estrogen plus progestin therapy may be a method to avoid unfavorable hemodynamic and metabolic effects of thiazide diuretics in hypertensive, postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

Hemodynamic and metabolic effects of estrogen plus progestin therapy in hypertensive postmenopausal women treated with an ACE-inhibitor or a diuretic

et al. 2014

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“…Regardless of the age, the metabolic results of patients did not show great concerns regarding the lipid profile. However, carbohydrate metabolism is a problem due to insulin resistance and glucose intolerance in many women over 65 years 4,6,8,9,21,23 . This seems to be more of an individual problem than an age influence 4,6,8,9,21,23 .…”

Section: Discussionmentioning

confidence: 99%

Gynecological cancer and metabolic screening of 1001 elderly Brazilian women

Bagnoli

Fonseca

Massabki

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE The aim of this study was to evaluate gynecological cancer and metabolic screening of Brazilian women aged 65 years or older. METHODS This retrospective descriptive study was conducted by including 1,001 Brazilian patients of the gynecological geriatric outpatient office of our institution to evaluate the influence of age on gynecological cancer and metabolic screening parameters at the first clinical visit. All patients were divided into three groups: a) 65 to 69 years; b) 70 to 74 years; c) ≥ 75 years. We considered clinical, laboratorial, and image data as variables of this study. The Chi-square test was used to assess the proportion of differences among the age groups, and Kruskal-Wallis was used for quantitative variables. RESULTS The values of BMI and height in the group over 75 years was lower than that of the 65 to 69 years (p = 0.001). Regardless of the age group, high arterial blood pressure levels were found in 85.45% of participants. Also, many patients had glucose intolerance in the blood. The pelvic ultrasonography showed abnormal endometrial echo thickness (> 5 mm) in 6.14% of patients, but with no significant statistical difference between the age groups. A total of 4.04% of patients had ovaries with high volume values ( > 6.1 mL). Abnormal mammography (BI-RADS 3 or 4) was observed in 12.21%. CONCLUSIONS our data suggest that a great reduction in BMI and stature is more frequent in the group over 75 years. Also, systemic arterial hypertension and carbohydrate disturbance are frequent morbidities in women over 65 years.

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“…There are several factors that influence it, including sex hormones, the renin-angiotensin system, oxidative stress, endo thelin, weight gain, and sympathetic activation. 23…”

Section: Discussionmentioning

confidence: 99%

Consequences of Overweight and Obesity in Adolescence against the Risk of Hypertension in Adulthood

Simbolon

Yorita

Talib

2019

Kesmas: National Public Health Journal

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Population increase in adolescence are associated with increased overweight and obesity problems. If this problem not early intervention will have an impact on increasing hypertension prevalence and risk of death. This research aimed to explain the consequences of overweight and obesity in adolescent to hypertension in adults. The study used Indonesian Family Life Survey (IFLS) data with a retrospective cohort study. Adolescent BMI measurements on 2007 and the risk of hypertension on 2014. Population are all adolescents aged 10-20 years in 2007. Sample of 1,697 adolescent who randomly IFLS 2007 with the inclusion criteria: biological children and a single birth, children living with biological parents, children remain alive until adulthood on 2014. Multivariate analysis used logistic regression. The study found 8.1% women and 5.6% men were overweight and obes. In adulthood, there was a 45.4% incidence of hypertension. Incidence of hypertension in men (67.3%) more than women (26.8%). The multivariate model showed adolescence BMI affects the blood pressure after controlled the BMI adult, adolescence blood pressure, area of residence, and gender.Gender interacts with adolescence BMI. The risk of hypertension in adulthood based on overweight and obese in adolescent boys is 3 times and girls is 2 times.

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Hypertension alone or related to the metabolic syndrome in postmenopausal women

Cited by 23 publications

References 49 publications

Hemodynamic and metabolic effects of estrogen plus progestin therapy in hypertensive postmenopausal women treated with an ACE-inhibitor or a diuretic

Hemodynamic and metabolic effects of estrogen plus progestin therapy in hypertensive postmenopausal women treated with an ACE-inhibitor or a diuretic

Gynecological cancer and metabolic screening of 1001 elderly Brazilian women

Consequences of Overweight and Obesity in Adolescence against the Risk of Hypertension in Adulthood

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